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    Or2y1g olfactory receptor family 2 subfamily Y member 1G [ Mus musculus (house mouse) ]

    Gene ID: 258463, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Or2y1gprovided by MGI
    Official Full Name
    olfactory receptor family 2 subfamily Y member 1Gprovided by MGI
    Primary source
    MGI:MGI:3031227
    See related
    Ensembl:ENSMUSG00000059864 AllianceGenome:MGI:3031227
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Olfr1393; MOR256-24
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Or2y1g in Genome Data Viewer
    Location:
    11 B1.2; 11 29.31 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (49154700..49183186)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (49263873..49292359)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6976 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:49057557-49057744 Neighboring gene predicted gene, 51893 Neighboring gene STARR-positive B cell enhancer ABC_E195 Neighboring gene mannoside acetylglucosaminyltransferase 1 Neighboring gene STARR-positive B cell enhancer ABC_E8994 Neighboring gene STARR-seq mESC enhancer starr_29373 Neighboring gene olfactory receptor family 2 subfamily Y member 1F Neighboring gene STARR-seq mESC enhancer starr_29374 Neighboring gene olfactory receptor family 2 subfamily Y member 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of renal olfactory receptor 1393 leads to improved glucose homeostasis in a type 1 diabetic mouse model. Schiazza AR, et al. Physiol Rep, 2021 Dec. PMID 34877823, Free PMC Article
    2. Renal olfactory receptor 1393 contributes to the progression of type 2 diabetes in a diet-induced obesity model. Shepard BD, et al. Am J Physiol Renal Physiol, 2019 Feb 1. PMID 30484350, Free PMC Article
    3. A Renal Olfactory Receptor Aids in Kidney Glucose Handling. Shepard BD, et al. Sci Rep, 2016 Oct 14. PMID 27739476, Free PMC Article
    4. Odorant and vomeronasal receptor genes in two mouse genome assemblies. Zhang X, et al. Genomics, 2004 May. PMID 15081110
    5. The olfactory receptor gene superfamily of the mouse. Zhang X, et al. Nat Neurosci, 2002 Feb. PMID 11802173

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of renal olfactory receptor 1393 leads to improved glucose homeostasis in a type 1 diabetic mouse model.
      Title: Loss of renal olfactory receptor 1393 leads to improved glucose homeostasis in a type 1 diabetic mouse model.
    2. Renal Olfr1393 can contribute to the progression of type 2 diabetes, likely as a regulator of Na(+)-glucose cotransport in the proximal tubule.
      Title: Renal olfactory receptor 1393 contributes to the progression of type 2 diabetes in a diet-induced obesity model.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC123557, MGC123558

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables olfactory receptor activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in detection of chemical stimulus involved in sensory perception of smell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sensory perception of smell ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    olfactory receptor family 2 subfamily Y member 1G
    Names
    GA_x6K02T2QP88-6154577-6153642
    MOR256-67_i
    olfactory receptor 1393
    olfactory receptor MOR256-24

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146471.1 → NP_666682.1  olfactory receptor family 2 subfamily Y member 1G

      See identical proteins and their annotated locations for NP_666682.1

      Status: PROVISIONAL

      Source sequence(s)
      AY073627
      Consensus CDS
      CCDS24603.1
      UniProtKB/TrEMBL
      Q8VFA7
      Related
      ENSMUSP00000077962.2, ENSMUST00000078932.2
      Conserved Domains (2) summary
      pfam00001
      Location:41 → 289
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:35 → 304
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      49154700..49183186
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246013.1 → XP_030101873.1  olfactory receptor family 2 subfamily Y member 1G isoform X2

      Conserved Domains (1) summary
      cd15947
      Location:8 → 249
      7tmA_OR2B-like; olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_017314558.2 → XP_017170047.1  olfactory receptor family 2 subfamily Y member 1G isoform X1

      Conserved Domains (1) summary
      cd15947
      Location:7 → 257
      7tmA_OR2B-like; olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. XM_006533360.3 → XP_006533423.1  olfactory receptor family 2 subfamily Y member 1G isoform X1

      See identical proteins and their annotated locations for XP_006533423.1

      Conserved Domains (1) summary
      cd15947
      Location:7 → 257
      7tmA_OR2B-like; olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    4. XM_017314560.2 → XP_017170049.1  olfactory receptor family 2 subfamily Y member 1G isoform X2

      Conserved Domains (1) summary
      cd15947
      Location:8 → 249
      7tmA_OR2B-like; olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    5. XM_030246012.1 → XP_030101872.1  olfactory receptor family 2 subfamily Y member 1G isoform X1

      Conserved Domains (1) summary
      cd15947
      Location:7 → 257
      7tmA_OR2B-like; olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    6. XM_030246011.1 → XP_030101871.1  olfactory receptor family 2 subfamily Y member 1G isoform X1

      Conserved Domains (1) summary
      cd15947
      Location:7 → 257
      7tmA_OR2B-like; olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    7. XM_017314559.2 → XP_017170048.1  olfactory receptor family 2 subfamily Y member 1G isoform X1

      Conserved Domains (1) summary
      cd15947
      Location:7 → 257
      7tmA_OR2B-like; olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    RNA

    1. XR_003949443.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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