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    Cacna1i calcium channel, voltage-dependent, alpha 1I subunit [ Mus musculus (house mouse) ]

    Gene ID: 239556, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cacna1iprovided by MGI
    Official Full Name
    calcium channel, voltage-dependent, alpha 1I subunitprovided by MGI
    Primary source
    MGI:MGI:2178051
    See related
    Ensembl:ENSMUSG00000022416 AllianceGenome:MGI:2178051
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ca(V)3.3
    Summary
    Predicted to enable low voltage-gated calcium channel activity and voltage-gated sodium channel activity. Acts upstream of or within neuronal action potential and sleep. Predicted to be part of voltage-gated sodium channel complex. Predicted to be active in neuron projection. Is expressed in brain. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human CACNA1I (calcium voltage-gated channel subunit alpha1 I). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in spleen adult (RPKM 8.3), frontal lobe adult (RPKM 8.1) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cacna1i in Genome Data Viewer
    Location:
    15 E1; 15 37.85 cM
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (80171439..80282493)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (80287238..80398292)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11599 Neighboring gene ribosomal protein S19 binding protein 1 Neighboring gene activating transcription factor 4 Neighboring gene predicted gene, 31319 Neighboring gene STARR-positive B cell enhancer ABC_E7394 Neighboring gene predicted gene, 41363 Neighboring gene predicted gene, 31369

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Differential expression of membrane conductances underlies spontaneous event initiation by rostral midline neurons in the embryonic mouse hindbrain. Moruzzi AM, et al. J Physiol, 2009 Nov 1. PMID 19736299, Free PMC Article
    2. Trigeminal neuropathic pain is alleviated by inhibition of Ca(v)3.3 T-type calcium channels in mice. Montera M, et al. Channels (Austin), 2021 Dec. PMID 33283622, Free PMC Article
    3. Effects of a patient-derived de novo coding alteration of CACNA1I in mice connect a schizophrenia risk gene with sleep spindle deficits. Ghoshal A, et al. Transl Psychiatry, 2020 Jan 23. PMID 32066662, Free PMC Article
    4. Immunological characterization of T-type voltage-dependent calcium channel CaV3.1 (alpha 1G) and CaV3.3 (alpha 1I) isoforms reveal differences in their localization, expression, and neural development. Yunker AM, et al. Neuroscience, 2003. PMID 12614673
    5. T-type calcium channels and thalamocortical rhythms in sleep: a perspective from studies of T-type calcium channel knockout mice. Lee J, et al. CNS Neurol Disord Drug Targets, 2007 Feb. PMID 17305554

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Trigeminal neuropathic pain is alleviated by inhibition of Cav3.3 T-type calcium channels in mice.
      Title: Trigeminal neuropathic pain is alleviated by inhibition of Ca(v)3.3 T-type calcium channels in mice.
    2. Homeostatic plasticity and burst activity are mediated by hyperpolarization-activated cation currents and T-type calcium channels in neuronal cultures.
      Title: Homeostatic plasticity and burst activity are mediated by hyperpolarization-activated cation currents and T-type calcium channels in neuronal cultures.
    3. Membrane-protein extraction and use of an intracellular protein-transport inhibitor showed that GDF-15 promoted CaV3.1 and CaV3.3 alpha-subunit expression by trafficking to the membrane.
      Title: Growth differentiation factor-15 promotes glutamate release in medial prefrontal cortex of mice through upregulation of T-type calcium channels.
    4. Extracellular pressure increases [Ca(2+)]i via Cav3.3, driving a PKC-beta- IKK- IkB-NF-kB pathway that stimulates cancer cell proliferation
      Title: Increased extracellular pressure stimulates tumor proliferation by a mechanosensitive calcium channel and PKC-β.
    5. using Ca(V)3.3(-/-) mice we found that Ca(V)3.3 channels trigger synaptic plasticity in reticular thalamic neurons
      Title: Synaptic plasticity at intrathalamic connections via CaV3.3 T-type Ca2+ channels and GluN2B-containing NMDA receptors.
    6. data identify a central role for Ca(V)3.3 channels in the rhythmogenic properties of the sleep-spindle generator and provide a molecular target to elucidate the roles of sleep spindles for brain function and development.
      Title: The Ca(V)3.3 calcium channel is the major sleep spindle pacemaker in thalamus.
    7. A T-type calcium channel required for normal function of a mammalian mechanoreceptor.
      Title: A T-type calcium channel required for normal function of a mammalian mechanoreceptor.
    8. Expression of T-type calcium channels increases during perinatal development in various brain regions and in the spinal cord.
      Title: Immunological characterization of T-type voltage-dependent calcium channel CaV3.1 (alpha 1G) and CaV3.3 (alpha 1I) isoforms reveal differences in their localization, expression, and neural development.
    9. alpha1(G) T-type calcium channels contribute to sleep waves as well as to behavioral state of sleep.
      Title: T-type calcium channels and thalamocortical rhythms in sleep: a perspective from studies of T-type calcium channel knockout mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables low voltage-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables low voltage-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables voltage-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion import IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion import ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in calcium ion transport into cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in membrane depolarization during action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuronal action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neuronal action potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of calcium ion-dependent exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within sleep IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated sodium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    voltage-dependent T-type calcium channel subunit alpha-1I
    Names
    low voltage-activated T-type calcium channel alpha-1 subunit (CACNA1I)
    low-voltage-activated calcium channel alpha13.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044308.2 → NP_001037773.2  voltage-dependent T-type calcium channel subunit alpha-1I

      Status: VALIDATED

      Source sequence(s)
      AC155313, AK147585, CJ259561
      Consensus CDS
      CCDS49670.1
      UniProtKB/TrEMBL
      E0CXK2, E9Q7P2
      Related
      ENSMUSP00000125063.2, ENSMUST00000160424.8
      Conserved Domains (1) summary
      pfam00520
      Location:615 → 824
      Ion_trans; Ion transport protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      80171439..80282493
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520949.2 → XP_006521012.1  voltage-dependent T-type calcium channel subunit alpha-1I isoform X1

      UniProtKB/TrEMBL
      E0CXK2
      Conserved Domains (2) summary
      PHA03307
      Location:1867 → 2226
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam00520
      Location:597 → 824
      Ion_trans; Ion transport protein

    2. XM_006520950.3 → XP_006521013.1  voltage-dependent T-type calcium channel subunit alpha-1I isoform X2

      UniProtKB/TrEMBL
      E0CXK2
      Conserved Domains (2) summary
      PHA03307
      Location:1854 → 2213
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam00520
      Location:597 → 824
      Ion_trans; Ion transport protein

    3. XM_030248558.2 → XP_030104418.1  voltage-dependent T-type calcium channel subunit alpha-1I isoform X3

      UniProtKB/TrEMBL
      E0CXK2
      Conserved Domains (2) summary
      PHA03307
      Location:1827 → 2186
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam00520
      Location:597 → 824
      Ion_trans; Ion transport protein
    Nucleotide Protein Strain
    Heading Accession and Version

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