Ninj1 ninjurin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ninj1provided by MGI
Official Full Name: ninjurin 1provided by MGI
Primary source: MGI:MGI:1196617
See related: Ensembl:ENSMUSG00000037966 AllianceGenome:MGI:1196617
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables cell-cell adhesion mediator activity; lipopolysaccharide binding activity; and membrane destabilizing activity. Involved in several processes, including ferroptosis; leukocyte chemotaxis; and positive regulation of defense response. Acts upstream of or within hyaloid vascular plexus regression and positive regulation of cell-matrix adhesion. Located in extracellular region; filopodium membrane; and synaptic membrane. Is active in plasma membrane. Is expressed in several structures, including body cavity or lining; central nervous system; eye; genitourinary system; and vertebral axis musculature. Orthologous to human NINJ1 (ninjurin 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in liver adult (RPKM 287.9), kidney adult (RPKM 192.9) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A5; 13 25.14 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (49341005..49349727)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (49187529..49196251)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural basis of NINJ1-mediated plasma membrane rupture in cell death.
Title: Structural basis of NINJ1-mediated plasma membrane rupture in cell death.
The Ninj1/Dusp1 Axis Contributes to Liver Ischemia Reperfusion Injury by Regulating Macrophage Activation and Neutrophil Infiltration.
Title: The Ninj1/Dusp1 Axis Contributes to Liver Ischemia Reperfusion Injury by Regulating Macrophage Activation and Neutrophil Infiltration.
NINJ1 Regulates Platelet Activation and PANoptosis in Septic Disseminated Intravascular Coagulation.
Title: NINJ1 Regulates Platelet Activation and PANoptosis in Septic Disseminated Intravascular Coagulation.
Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death.
Title: Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death.
Deficiency of Ninjurin1 attenuates LPS/D-galactosamine-induced acute liver failure by reducing TNF-alpha-induced apoptosis in hepatocytes.
Title: Deficiency of Ninjurin1 attenuates LPS/D-galactosamine-induced acute liver failure by reducing TNF-α-induced apoptosis in hepatocytes.
miR-125a-5p attenuates macrophage-mediated vascular dysfunction by targeting Ninjurin1.
Title: miR-125a-5p attenuates macrophage-mediated vascular dysfunction by targeting Ninjurin1.
Anti-Inflammatory Actions of Soluble Ninjurin-1 Ameliorate Atherosclerosis.
Title: Anti-Inflammatory Actions of Soluble Ninjurin-1 Ameliorate Atherosclerosis.
Pericyte-specific deletion of ninjurin-1 induces fragile vasa vasorum formation and enhances intimal hyperplasia of injured vasculature.
Title: Pericyte-specific deletion of ninjurin-1 induces fragile vasa vasorum formation and enhances intimal hyperplasia of injured vasculature.
NINJ1 mediates plasma membrane rupture during lytic cell death.
Title: NINJ1 mediates plasma membrane rupture during lytic cell death.
Detrimental Role of Nerve Injury-Induced Protein 1 in Myeloid Cells under Intestinal Inflammatory Conditions.
Title: Detrimental Role of Nerve Injury-Induced Protein 1 in Myeloid Cells under Intestinal Inflammatory Conditions.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (4) 1 citation

General gene information

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Markers

U91513 (e-PCR)
- UniSTS:160296

AU024536 (e-PCR)
- UniSTS:180530

NoName (e-PCR)
- UniSTS:493050

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cell adhesion mediator activity	IDA Inferred from Direct Assay more info	PubMed
enables cell adhesion mediator activity	ISO Inferred from Sequence Orthology more info
enables cell-cell adhesion mediator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables lipopolysaccharide binding	IDA Inferred from Direct Assay more info	PubMed
enables lipopolysaccharide binding	ISO Inferred from Sequence Orthology more info
enables membrane destabilizing activity	IDA Inferred from Direct Assay more info	PubMed
enables membrane destabilizing activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cellular hyperosmotic response	IDA Inferred from Direct Assay more info	PubMed
involved_in chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in cytolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in ferroptosis	IDA Inferred from Direct Assay more info	PubMed
involved_in heterotypic cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hyaloid vascular plexus regression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in killing of cells of another organism	IEA Inferred from Electronic Annotation more info
involved_in leukocyte chemotaxis involved in inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in leukocyte chemotaxis involved in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leukocyte chemotaxis involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in macrophage chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pericyte cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoclast development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of toll-like receptor 4 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in programmed necrotic cell death	IDA Inferred from Direct Assay more info	PubMed
involved_in protein homooligomerization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in pyroptotic cell death	IDA Inferred from Direct Assay more info	PubMed
involved_in pyroptotic inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of monocyte chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in tissue regeneration	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in filopodium membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ninjurin-1

Names: nerve injury-induced protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.