NMU neuromedin U [Homo sapiens (human)] - Gene

Summary

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Official Symbol: NMUprovided by HGNC
Official Full Name: neuromedin Uprovided by HGNC
Primary source: HGNC:HGNC:7859
See related: Ensembl:ENSG00000109255 MIM:605103; AllianceGenome:HGNC:7859
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in pain, stress, immune-mediated inflammatory diseases and feeding regulation. Increased expression of this gene was observed in renal, pancreatic and lung cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. Some of these isoforms may undergo similar processing to generate the mature peptide. [provided by RefSeq, Jul 2015]
Expression: Biased expression in esophagus (RPKM 5.6), skin (RPKM 5.5) and 6 other tissues See more
Orthologs: mouse all
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Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (55595231..55636793, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (59083363..59124965, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (56461398..56502960, complement)

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of NMU and NMUR1 in tryptase-positive mast cells and PBLs in allergic rhinitis patients' nasal mucosa.
Title: Expression of NMU and NMUR1 in tryptase-positive mast cells and PBLs in allergic rhinitis patients' nasal mucosa.
Neuromedin U regulates the anti-tumor activity of CD8[+] T cells and glycolysis of tumor cells in the tumor microenvironment of pancreatic ductal adenocarcinoma in an NMUR1-dependent manner.
Title: Neuromedin U regulates the anti-tumor activity of CD8(+) T cells and glycolysis of tumor cells in the tumor microenvironment of pancreatic ductal adenocarcinoma in an NMUR1-dependent manner.
To be or not to be direct: The role of neuromedin U in neuro-eosinophil crosstalk.
Title: To be or not to be direct: The role of neuromedin U in neuro-eosinophil crosstalk.
Neuromedin U contributes to radiation resistance in colorectal cancer via YAP/TAZ signaling activation.
Title: Neuromedin U contributes to radiation resistance in colorectal cancer via YAP/TAZ signaling activation.
The prognostic value of neuromedin U in patients with hepatocellular carcinoma.
Title: The prognostic value of neuromedin U in patients with hepatocellular carcinoma.
Association between variants of neuromedin U gene and taste thresholds and food preferences in European children: Results from the IDEFICS study.
Title: Association between variants of neuromedin U gene and taste thresholds and food preferences in European children: Results from the IDEFICS study.
Results identified NMU as highly expressed in non-small cell lung cancer (NSCLC) tissues and cell lines. Furthermore, integrative bioinformatics analyses demonstrate that NMU may confer the alectinib resistance in NSCLC via multiple mechanisms.
Title: Identification of NMU as a potential gene conferring alectinib resistance in non-small cell lung cancer based on bioinformatics analyses.
NMU might contribute to progression of NMUR2-positive breast cancer
Title: Oncogenic features of neuromedin U in breast cancer are associated with NMUR2 expression involving crosstalk with members of the WNT signaling pathway.
The anti-tumorigenic effect of HAND2-AS1 in endometrioid endometrial carcinoma was mediated by down-regulating neuromedin U expression.
Title: Long non-coding RNA HAND2-AS1 inhibits invasion and metastasis in endometrioid endometrial carcinoma through inactivating neuromedin U.
Results indicate a mechanism of action for neuromedin U (NmU) in HER2-overexpressing breast cancer that enhances resistance to HER2-targeted drugs through conferring cancer stem cell (CSC) characteristics and expansion of the CSC phenotype.
Title: Neuromedin U alters bioenergetics and expands the cancer stem cell phenotype in HER2-positive breast cancer.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-X76029 (e-PCR)
- UniSTS:19787

D4S3177 (e-PCR)
- UniSTS:73140

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables neuromedin U receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	TAS Traceable Author Statement more info	PubMed
enables type 1 neuromedin U receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables type 2 neuromedin U receptor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in energy homeostasis	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of smooth muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of feeding behavior	IEA Inferred from Electronic Annotation more info
involved_in regulation of grooming behavior	IEA Inferred from Electronic Annotation more info
involved_in temperature homeostasis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in terminal bouton	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: neuromedin-U

Names: neuromedin U precursor-related peptide/neuromedin U preproprotein; prepro-NMU

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001292045.2 → NP_001278974.1 neuromedin-U isoform 2 precursor

See identical proteins and their annotated locations for NP_001278974.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter than isoform 1. This isoform (2) may undergo processing similar to isoform 1 to generate mature peptide.

Source sequence(s)

BC012908, BI603117, BQ049320

Consensus CDS

CCDS75125.1

UniProtKB/TrEMBL

A0A0B4J202, D6RBC9

Related

ENSP00000422399.1, ENST00000511469.5

Conserved Domains (1) summary

smart00084
Location:126 → 150

NMU; Neuromedin U
NM_001292046.2 → NP_001278975.1 neuromedin-U isoform 3 precursor

See identical proteins and their annotated locations for NP_001278975.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 3, which lacks an internal segment and is shorter than isoform 1.

Source sequence(s)

AJ510133, BC012908, BF185217, BI603117, BQ049320

Consensus CDS

CCDS77914.1

UniProtKB/TrEMBL

E9PDJ7

Related

ENSP00000422870.1, ENST00000507338.1

Conserved Domains (1) summary

smart00084
Location:119 → 141

NMU; Neuromedin U
NM_006681.4 → NP_006672.1 neuromedin-U isoform 1 preproprotein

See identical proteins and their annotated locations for NP_006672.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

BC012908, BI603117, X76029

Consensus CDS

CCDS3501.1

UniProtKB/Swiss-Prot

P48645

UniProtKB/TrEMBL

A0A250SH36, D6RBC9

Related

ENSP00000264218.3, ENST00000264218.7

Conserved Domains (1) summary

smart00084
Location:142 → 166

NMU; Neuromedin U

RNA

NR_120489.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (4) contains an alternate 5' terminal exon and lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.

Source sequence(s)

AC024243, BC012908, CN343322