U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    LINC00973 long intergenic non-protein coding RNA 973 [ Homo sapiens (human) ]

    Gene ID: 105374003, updated on 17-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    LINC00973provided by HGNC
    Official Full Name
    long intergenic non-protein coding RNA 973provided by HGNC
    Primary source
    HGNC:HGNC:48868
    See related
    AllianceGenome:HGNC:48868
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Low expression observed in reference dataset See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See LINC00973 in Genome Data Viewer
    Location:
    3q12.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (98914566..98998841)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (101622897..101707180)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (98633410..98717685)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancers GRCh37_chr3:98619438-98620154 and GRCh37_chr3:98620155-98620870 Neighboring gene uncharacterized LOC105374002 Neighboring gene RNA, U6 small nuclear 1263, pseudogene Neighboring gene Sharpr-MPRA regulatory region 3286 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:98647410-98647601 Neighboring gene U7 small nuclear RNA Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:98783203-98783703 Neighboring gene actin gamma 1 pseudogene 13 Neighboring gene uncharacterized LOC124909399 Neighboring gene uncharacterized LOC107986104

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. LINC00973 Induces Proliferation Arrest of Drug-Treated Cancer Cells by Preventing p21 Degradation. Karpov DS, et al. Int J Mol Sci, 2020 Nov 6. PMID 33171937, Free PMC Article
    2. Expression of long non-coding RNA LINC00973 is consistently increased upon treatment of colon cancer cells with different chemotherapeutic drugs. Zinovieva OL, et al. Biochimie, 2018 Aug. PMID 29870803
    3. Risk score based on ten lncRNA-mRNA expression predicts the survival of stage II-III colorectal carcinoma. Diao R, et al. PLoS One, 2017. PMID 28796819, Free PMC Article
    4. LINC00973 is involved in cancer immune suppression through positive regulation of Siglec-15 in clear-cell renal cell carcinoma. Liu Y, et al. Cancer Sci, 2020 Oct. PMID 32780490, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LINC00973 Induces Proliferation Arrest of Drug-Treated Cancer Cells by Preventing p21 Degradation.
      Title: LINC00973 Induces Proliferation Arrest of Drug-Treated Cancer Cells by Preventing p21 Degradation.
    2. LINC00973 is involved in cancer immune suppression through positive regulation of Siglec-15 in clear-cell renal cell carcinoma.
      Title: LINC00973 is involved in cancer immune suppression through positive regulation of Siglec-15 in clear-cell renal cell carcinoma.
    Submit: New GeneRIF Correction

    Phenotypes

    Go to the top of the page Help

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    Genotypes

    General gene information

    Go to the top of the page Help

    Other Names

    • CTD-2021J15.2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_186665.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC026303, AC091212

    2. NR_186666.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC091212, AC106704

    3. NR_186667.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC091212, AC106704

    4. NR_186668.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC091212, AC106704

    5. NR_186669.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC091212, AC106704

    6. NR_186670.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC091212, AC106704

    7. NR_186671.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC091212

    8. NR_186672.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC091212

    9. NR_186673.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC091212

    10. NR_186674.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC091212

    11. NR_186675.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC091212

    12. NR_186676.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC091212

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      98914566..98998841
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      101622897..101707180
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials