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    GJA9-MYCBP GJA9-MYCBP readthrough [ Homo sapiens (human) ]

    Gene ID: 100527950, updated on 17-Sep-2024

    Summary

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    Gene symbol
    GJA9-MYCBP
    Gene description
    GJA9-MYCBP readthrough
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Cx58; Cx59; GJA9; GJA10
    Summary
    This locus represents naturally occurring read-through transcription between the neighboring GJA9 (gap junction protein, alpha 9, 59kDa) and MYCBP (c-myc binding protein) genes on chromosome 1. Alternative splicing results in multiple transcript variants. These variants are either candidates for nonsense-mediated mRNA decay (NMD) and/or they lack a significant open reading frame, thus they are unlikely to produce protein products. [provided by RefSeq, Dec 2010]
    Expression
    Ubiquitous expression in testis (RPKM 7.3), colon (RPKM 5.3) and 25 other tissues See more
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    Genomic context

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    See GJA9-MYCBP in Genome Data Viewer
    Location:
    1p34.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (38862490..38881626, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (38729722..38748858, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (39328162..39347298, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378660 Neighboring gene HSPA5 pseudogene 1 Neighboring gene VISTA enhancer hs1031 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:39206875-39207549 Neighboring gene Sharpr-MPRA regulatory region 12321 Neighboring gene NANOG hESC enhancer GRCh37_chr1:39212546-39213129 Neighboring gene VISTA enhancer hs1139 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:39253877-39254442 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 798 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:39281537-39282038 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:39282039-39282538 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 688 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:39285036-39285203 Neighboring gene Sharpr-MPRA regulatory region 3933 Neighboring gene Ras related GTP binding C Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:39338054-39338576 Neighboring gene RRAGC divergent transcript Neighboring gene ReSE screen-validated silencer GRCh37_chr1:39345299-39345483 Neighboring gene MYC binding protein Neighboring gene gap junction protein alpha 9 Neighboring gene rhomboid like 2 Neighboring gene uncharacterized LOC105378662 Neighboring gene RNA, U6 small nuclear 605, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. Prakash T, et al. PLoS One, 2010 Oct 12. PMID 20967262, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Readthrough GJA9-MYCBP

    Included genes: MYCBP, GJA9

    Other Names

    • Connexin-58
    • Connexin-59
    • Gap junction alpha-10 protein
    • Gap junction alpha-9 protein

    Clone Names

    • FLJ41056

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_037633.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AL139260, BC051675

    2. NR_037634.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate segment in the central region, compared to variant 1.
      Source sequence(s)
      AK123051, AL139260

    3. NR_037635.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an internal exon, compared to variant 1.
      Source sequence(s)
      AL139260, FY211295

    4. NR_037636.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two internal exons, compared to variant 1.
      Source sequence(s)
      AL139260, FY211253

    5. NR_037637.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks three internal exons and uses an alternate splice site, compared to variant 1.
      Source sequence(s)
      AL139260, FY210901

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      38862490..38881626 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      38729722..38748858 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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