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    SPDYE18 speedy/RINGO cell cycle regulator family member E18 [ Homo sapiens (human) ]

    Gene ID: 100505767, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SPDYE18provided by HGNC
    Official Full Name
    speedy/RINGO cell cycle regulator family member E18provided by HGNC
    Primary source
    HGNC:HGNC:51514
    See related
    Ensembl:ENSG00000205482 AllianceGenome:HGNC:51514
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable protein kinase binding activity. Predicted to be involved in positive regulation of cyclin-dependent protein serine/threonine kinase activity. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 7.2), thyroid (RPKM 1.9) and 23 other tissues See more
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    Genomic context

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    See SPDYE18 in Genome Data Viewer
    Location:
    7q11.23
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (77050391..77062558, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (78301438..78313660, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (76679708..76691875, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene DTX2P1-UPK3BP1-PMS2P11 readthrough, transcribed pseudogene Neighboring gene Sharpr-MPRA regulatory region 3059 Neighboring gene uroplakin 3B pseudogene 1 Neighboring gene PMS1 homolog 2, mismatch repair system component pseudogene 11 Neighboring gene speedy/RINGO cell cycle regulator family member E17 Neighboring gene PMS1 homolog 2, mismatch repair system component pseudogene 9 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:76693975-76694649 Neighboring gene SNF2 related chromatin remodeling ATPase 5 pseudogene Neighboring gene family with sequence similarity 185, member A pseudogene Neighboring gene ribosomal protein L7a pseudogene 43

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. Dias Neto E, et al. Proc Natl Acad Sci U S A, 2000 Mar 28. PMID 10737800, Free PMC Article
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    speedy protein E18
    Names
    Speedy protein E18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001351348.1 → NP_001338277.1  speedy protein E18 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC007000
      Conserved Domains (1) summary
      pfam11357
      Location:117 → 271
      Spy1; Cell cycle regulatory protein

    2. NM_001394953.1 → NP_001381882.1  speedy protein E18 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC007000
      Consensus CDS
      CCDS94131.1
      UniProtKB/Swiss-Prot
      P0DV79
      UniProtKB/TrEMBL
      A0A8I5KS96
      Related
      ENSP00000509550.1, ENST00000510091.4

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      77050391..77062558 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      78301438..78313660 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0DV79.1 GenPept UniProtKB/Swiss-Prot:P0DV79

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials