FRAT1 FRAT regulator of WNT signaling pathway 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FRAT1provided by HGNC
Official Full Name: FRAT regulator of WNT signaling pathway 1provided by HGNC
Primary source: HGNC:HGNC:3944
See related: Ensembl:ENSG00000165879 MIM:602503; AllianceGenome:HGNC:3944
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis. [provided by RefSeq, Oct 2008]
Orthologs: mouse all
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Genomic context

Location:: 10q24.1

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (97319271..97321915)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (98199470..98202113)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (99079028..99081672)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The miR-3648/FRAT1-FRAT2/c-Myc negative feedback loop modulates the metastasis and invasion of gastric cancer cells.
Title: The miR-3648/FRAT1-FRAT2/c-Myc negative feedback loop modulates the metastasis and invasion of gastric cancer cells.
FRAT1 promotes the angiogenic properties of human glioblastoma cells via VEGFA.
Title: FRAT1 promotes the angiogenic properties of human glioblastoma cells via VEGFA.
LncRNA CCAT1 promotes prostate cancer cells proliferation, migration, and invasion through regulation of miR-490-3p/FRAT1 axis.
Title: LncRNA CCAT1 promotes prostate cancer cells proliferation, migration, and invasion through regulation of miR-490-3p/FRAT1 axis.
The results of the present study suggest that nuclear FRAT1 activates the Wnt/beta-catenin signaling pathway and confers an increase in prostate cancer cell growth.
Title: Frequently rearranged in advanced T‑cell lymphomas‑1 demonstrates oncogenic properties in prostate cancer.
These data suggest a potential role for targeting FRAT1 in the prevention of hypoxia-induced HCC cancer progression and metastasis mediated by epithelial-to-mesenchymal transition
Title: Knockdown of FRAT1 inhibits hypoxia-induced epithelial-to-mesenchymal transition via suppression of the Wnt/β-catenin pathway in hepatocellular carcinoma cells.
FRAT1 and ABCG2 overexpression is associated with carcinogenesis, progression, and poor prognosis in patients with Pancreatic ductal adenocarcinoma.
Title: The clinical significance of FRAT1 and ABCG2 expression in pancreatic ductal adenocarcinoma.
Positive ROR2 and FRAT1 expression is associated with the progression and poor prognosis of chondrosarcoma.
Title: The clinical pathological significance of FRAT1 and ROR2 expression in cartilage tumors.
FRAT1 overexpression correlates with pathologic grade, proliferation, invasion and angiogenesis in brain gliomas.
Title: Overexpression of FRAT1 is associated with malignant phenotype and poor prognosis in human gliomas.
The mechanism of inhibiting beta-catenin phosphorylation involves the NDRG1-mediated upregulation of the GSK3beta-binding protein FRAT1.
Title: The metastasis suppressor NDRG1 modulates the phosphorylation and nuclear translocation of β-catenin through mechanisms involving FRAT1 and PAK4.
These results highlight the potential role of FRAT1 in tumorigenesis and progression of glioblastoma.
Title: Knockdown of FRAT1 expression by RNA interference inhibits human glioblastoma cell growth, migration and invasion.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

FRAT1_113 (e-PCR)
- UniSTS:277256

RH99329 (e-PCR)
- UniSTS:89409

RH71241 (e-PCR)
- UniSTS:13795

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables molecular function inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of protein export from nucleus	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: proto-oncogene FRAT1

Names: FRAT-1; FRAT1, WNT signaling pathway regulator; frequently rearranged in advanced T-cell lymphomas 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005479.4 → NP_005470.2 proto-oncogene FRAT1

See identical proteins and their annotated locations for NP_005470.2

Status: REVIEWED

Source sequence(s)

AL355490

Consensus CDS

CCDS7455.1

UniProtKB/Swiss-Prot

Q5JTI1, Q8NE74, Q8TDW9, Q92837

Related

ENSP00000360060.3, ENST00000371021.5

Conserved Domains (1) summary

pfam05350
Location:1 → 239

GSK-3_bind; Glycogen synthase kinase-3 binding

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000010.11 Reference GRCh38.p14 Primary Assembly

Range

97319271..97321915

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060934.1 Alternate T2T-CHM13v2.0

Range

98199470..98202113

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_181355.1: Suppressed sequence

Description

NM_181355.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.