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PKT3 peroxisomal 3-ketoacyl-CoA thiolase 3 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 817876, updated on 18-Sep-2024

Summary

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Official Symbol
PKT3
Official Full Name
peroxisomal 3-ketoacyl-CoA thiolase 3
Primary source
TAIR:AT2G33150
Locus tag
AT2G33150
See related
Araport:AT2G33150
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
3-KETOACYL-COA THIOLASE 2; KAT2; PED1; peroxisomal 3-ketoacyl-CoA thiolase 3; PEROXISOME DEFECTIVE 1; potassium channel in Arabidopsis thaliana 2
Summary
Encodes an organellar (peroxisome, glyoxysome) 3-ketoacyl-CoA thiolase, involved in fatty acid b-oxidation during germination and subsequent seedling growth. Mutants have defects in glyoxysomal fatty acid beta-oxidation. EC2.3.1.16 thiolase.
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Genomic context

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See PKT3 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
14
Sequence:
Chromosome: 2; NC_003071.7 (14047478..14051400, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene ralf-like 18 Neighboring gene tRNA-Met Neighboring gene glycoside hydrolase family 28 protein / polygalacturonase (pectinase) family protein Neighboring gene Leucine-rich repeat receptor-like protein kinase family protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression of the beta-oxidation gene 3-ketoacyl-CoA thiolase 2 (KAT2) is required for the timely onset of natural and dark-induced leaf senescence in Arabidopsis. Castillo MC, et al. J Exp Bot, 2008. PMID 18441338, Free PMC Article
  2. 2,4-Dichlorophenoxybutyric acid-resistant mutants of Arabidopsis have defects in glyoxysomal fatty acid beta-oxidation. Hayashi M, et al. Plant Cell, 1998 Feb. PMID 9490742, Free PMC Article
  3. Requirement for 3-ketoacyl-CoA thiolase-2 in peroxisome development, fatty acid beta-oxidation and breakdown of triacylglycerol in lipid bodies of Arabidopsis seedlings. Germain V, et al. Plant J, 2001 Oct. PMID 11696182
  4. The Arabidopsis 3-ketoacyl-CoA thiolase-2 (kat2-1) mutant exhibits increased flowering but reduced reproductive success. Footitt S, et al. J Exp Bot, 2007. PMID 17728299
  5. Novel proteins, putative membrane transporters, and an integrated metabolic network are revealed by quantitative proteomic analysis of Arabidopsis cell culture peroxisomes. Eubel H, et al. Plant Physiol, 2008 Dec. PMID 18931141, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Peroxisomal KAT2 and KAT5 have partially redundant functions and operate downstream of AIM1 to provide beta-oxidation functions essential for inflorescence development and fertility.
    Title: Knockout of the two evolutionarily conserved peroxisomal 3-ketoacyl-CoA thiolases in Arabidopsis recapitulates the abnormal inflorescence meristem 1 phenotype.
  2. KAT2 as an essential component for the timely onset of leaf senescence in Arabidopsis.
    Title: Expression of the beta-oxidation gene 3-ketoacyl-CoA thiolase 2 (KAT2) is required for the timely onset of natural and dark-induced leaf senescence in Arabidopsis.
  3. Mutations within the 3-ketoacyl-CoA thiolase 2 (KAT2) gene interferes with the balance between silique development and the continued initiation of floral meristems. [KAT2]
    Title: The Arabidopsis 3-ketoacyl-CoA thiolase-2 (kat2-1) mutant exhibits increased flowering but reduced reproductive success.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_128874.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables acetyl-CoA C-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acetyl-CoA C-acyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables acetyl-CoA C-acyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within fatty acid beta-oxidation TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within fatty acid oxidation TAS
Traceable Author Statement
more info
  
acts_upstream_of_or_within glyoxysome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within jasmonic acid biosynthetic process NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within positive regulation of abscisic acid-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to wounding NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
NOT located_in cytosol RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus HDA PubMed 
located_in peroxisome HDA PubMed 
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plant-type vacuole HDA PubMed 

General protein information

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Preferred Names
peroxisomal 3-ketoacyl-CoA thiolase 3
NP_180873.1
  • peroxisomal 3-ketoacyl-CoA thiolase 3 (PKT3); FUNCTIONS IN: acetyl-CoA C-acyltransferase activity; INVOLVED IN: fatty acid beta-oxidation, jasmonic acid biosynthetic process, response to wounding, fatty acid oxidation, glyoxysome organization; LOCATED IN: in 6 components; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Thiolase (InterPro:IPR002155), Thiolase, active site (InterPro:IPR020610), Thiolase, N-terminal (InterPro:IPR020616), Thiolase, conserved site (InterPro:IPR020613), Thiolase, C-terminal (InterPro:IPR020617), Thiolase-like, subgroup (InterPro:IPR016038), Thiolase-like (InterPro:IPR016039), Thiolase, acyl-enzyme intermediate active site (InterPro:IPR020615); BEST Arabidopsis thaliana protein match is: peroxisomal 3-ketoacyl-CoA thiolase 4 (TAIR:AT1G04710.1); Has 22382 Blast hits to 22371 proteins in 2261 species: Archae - 414; Bacteria - 14116; Metazoa - 985; Fungi - 655; Plants - 282; Viruses - 0; Other Eukaryotes - 5930 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    14047478..14051400 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_128874.4 → NP_180873.1  peroxisomal 3-ketoacyl-CoA thiolase 3 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_180873.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q56WD9, Q93Z35, Q9S7M3
    UniProtKB/TrEMBL
    A0A178VRP9, A0A5S9X3F2
    Conserved Domains (1) summary
    PLN02287
    Location:1 → 456
    PLN02287; 3-ketoacyl-CoA thiolase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q56WD9.2

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