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    CVP2 DNAse I-like superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837048, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CVP2
    Official Full Name
    DNAse I-like superfamily protein
    Primary source
    TAIR:AT1G05470
    Locus tag
    AT1G05470
    See related
    Araport:AT1G05470
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    COTYLEDON VASCULAR PATTERN 2; T25N20.12; T25N20_12
    Summary
    Encodes an inositol polyphosphate 5' phosphatase (5PTase) that is required for the proper recruitment of cells into developing vascular tissue in leaves and cotyledons. It is most similar to Type I 5PTases that are known to cleave a phosphate from IP3 or IP4. cvp2 mutants have elevated levels of IP3 and are hypersensitive to ABA in seed germination assays.
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    Genomic context

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    See CVP2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    13
    Sequence:
    Chromosome: 1; NC_003070.9 (1607202..1611840, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene C-8 sterol isomerase Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene chromatin remodeling 31 Neighboring gene Calcium-dependent lipid-binding (CaLB domain) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cotyledon vascular pattern2-mediated inositol (1,4,5) triphosphate signal transduction is essential for closed venation patterns of Arabidopsis foliar organs. Carland FM, et al. Plant Cell, 2004 May. PMID 15100402, Free PMC Article
    2. Primary root protophloem differentiation requires balanced phosphatidylinositol-4,5-biphosphate levels and systemically affects root branching. Rodriguez-Villalon A, et al. Development, 2015 Apr 15. PMID 25813544
    3. CVP2- and CVL1-mediated phosphoinositide signaling as a regulator of the ARF GAP SFC/VAN3 in establishment of foliar vein patterns. Carland F, et al. Plant J, 2009 Sep. PMID 19473324
    4. Genetic regulation of vascular tissue patterning in Arabidopsis. Carland FM, et al. Plant Cell, 1999 Nov. PMID 10559439, Free PMC Article
    5. Phosphoinositide-dependent regulation of VAN3 ARF-GAP localization and activity essential for vascular tissue continuity in plants. Naramoto S, et al. Development, 2009 May. PMID 19363154

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CVP2 and CVL1 regulate vein continuity and cell polarity by generating a specific phosphoinositide ligand for SFC/VAN3.
      Title: CVP2- and CVL1-mediated phosphoinositide signaling as a regulator of the ARF GAP SFC/VAN3 in establishment of foliar vein patterns.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001331550.1
    NM_100426.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables inositol trisphosphate phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables inositol-polyphosphate 5-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    NOT involved_in auxin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cotyledon vascular tissue pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within inositol trisphosphate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf vascular tissue pattern formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf vascular tissue pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylinositol dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidylinositol dephosphorylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within procambium histogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within xylem and phloem pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    DNAse I-like superfamily protein
    NP_172038.4
    • COTYLEDON VASCULAR PATTERN 2 (CVP2); FUNCTIONS IN: hydrolase activity, inositol trisphosphate phosphatase activity; INVOLVED IN: in 8 processes; LOCATED IN: cellular_component unknown; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Inositol polyphosphate related phosphatase (InterPro:IPR000300), Endonuclease/exonuclease/phosphatase (InterPro:IPR005135); BEST Arabidopsis thaliana protein match is: CVP2 like 1 (TAIR:AT2G32010.2); Has 2640 Blast hits to 2079 proteins in 233 species: Archae - 0; Bacteria - 28; Metazoa - 855; Fungi - 611; Plants - 735; Viruses - 0; Other Eukaryotes - 411 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      1607202..1611840 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100426.5 → NP_172038.4  DNAse I-like superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172038.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LR47
      UniProtKB/TrEMBL
      A0A178WIE4, A0A5S9SRT5, A0A7G2DSX5
      Conserved Domains (1) summary
      cl00490
      Location:1 → 605
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    2. NM_001331550.1 → NP_001322092.1  DNAse I-like superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LR47
      UniProtKB/TrEMBL
      A0A178WIE4, A0A5S9SRT5, A0A7G2DSX5
      Conserved Domains (1) summary
      cl00490
      Location:1 → 605
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LR47.2

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