SCRN1 secernin 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SCRN1provided by HGNC
Official Full Name: secernin 1provided by HGNC
Primary source: HGNC:HGNC:22192
See related: Ensembl:ENSG00000136193 MIM:614965; AllianceGenome:HGNC:22192
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SES1
Summary: This gene likely encodes a member of the secernin family of proteins. A similar protein in rat functions in regulation of exocytosis in mast cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]
Expression: Broad expression in brain (RPKM 69.1), testis (RPKM 17.1) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7p14.3

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (29920103..29990289, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (30057799..30127994, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (29959719..30029905, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SCRN1: A cerebrospinal fluid biomarker correlating with tau in Alzheimer's disease.
Title: SCRN1: A cerebrospinal fluid biomarker correlating with tau in Alzheimer's disease.
Knockdown of Secernin 1 inhibit cell invasion and migration by activating the TGF-beta/Smad3 pathway in oral squamous cell carcinomas.
Title: Knockdown of Secernin 1 inhibit cell invasion and migration by activating the TGF-β/Smad3 pathway in oral squamous cell carcinomas.
Secernin-1 is a novel phosphorylated tau binding protein that accumulates in Alzheimer's disease and not in other tauopathies.
Title: Secernin-1 is a novel phosphorylated tau binding protein that accumulates in Alzheimer's disease and not in other tauopathies.
Upregulation of SCRN1 is associated with acquired resistance to erlotinib in non-small cell lung cancer.
Title: Integrated genomic approaches identify upregulation of SCRN1 as a novel mechanism associated with acquired resistance to erlotinib in PC9 cells harboring oncogenic EGFR mutation.
Luciferase report assay showed that the rs6976789 variant T allele influenced the binding ability of miR-148a. Our results suggested that the SCRN1 rs6976789 polymorphism may play an important role in the GC development and progression
Title: A genetic variant of miR-148a binding site in the SCRN1 3'-UTR is associated with susceptibility and prognosis of gastric cancer.
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
Title: Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
in synovial sarcoma, metastasis-free survival was significantly higher in the group with high secernin-1 expression compared to low expression; results indicate secernin-1 may be used as a biomarker to predict overall and metastasis-free survival
Title: Secernin-1 as a novel prognostic biomarker candidate of synovial sarcoma revealed by proteomics.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
SCRN1 expression is a prognostic factor in colorectal cancer patients
Title: SCRN1 is a novel marker for prognosis in colorectal cancer.
This protein has been found differentially expressed in the anterior cingulate cortex from patients with schizophrenia
Title: Sex-specific proteome differences in the anterior cingulate cortex of schizophrenia.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D7S2271E (e-PCR)
- UniSTS:58886

SHGC-171947 (e-PCR)
- UniSTS:184587

D7S370 (e-PCR)
- UniSTS:21049

RH66311 (e-PCR)
- UniSTS:74334

G54061 (e-PCR)
- UniSTS:109443

RH25406 (e-PCR)
- UniSTS:74916

SHGC-56008 (e-PCR)
- UniSTS:70864

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cysteine-type exopeptidase activity	IEA Inferred from Electronic Annotation more info
enables dipeptidase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in exocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic vesicle cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: secernin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_047114.1 RefSeqGene

Range

5489..75181

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001145513.1 → NP_001138985.1 secernin-1 isoform a

See identical proteins and their annotated locations for NP_001138985.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein (isoform a).

Source sequence(s)

AA910381, AB071705, BC040492, DC307846

Consensus CDS

CCDS5422.1

UniProtKB/Swiss-Prot

A8K0E9, B4DHM0, B4DIP5, C9JPG0, Q12765, Q25QX7, Q8IWD1

UniProtKB/TrEMBL

A0A090N7T9

Related

ENSP00000409068.1, ENST00000426154.5

Conserved Domains (1) summary

cl00467
Location:18 → 227

Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
NM_001145514.1 → NP_001138986.1 secernin-1 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at an alternate upstream start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is longer than isoform 1.

Source sequence(s)

AA910381, AB071705, AK295172

Consensus CDS

CCDS47567.1

UniProtKB/Swiss-Prot

Q12765

Related

ENSP00000388942.1, ENST00000434476.6

Conserved Domains (1) summary

cl41909
Location:38 → 247

PepD; Dipeptidase [Amino acid transport and metabolism]
NM_001145515.2 → NP_001138987.1 secernin-1 isoform c

See identical proteins and their annotated locations for NP_001138987.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) is shorter than isoform 1.

Source sequence(s)

AA910381, AB071705, AK295713, DC370097

Consensus CDS

CCDS47568.1

Related

ENSP00000414245.2, ENST00000425819.6

Conserved Domains (1) summary

cl00467
Location:2 → 159

Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
NM_014766.5 → NP_055581.3 secernin-1 isoform a

See identical proteins and their annotated locations for NP_055581.3

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein (isoform a).

Source sequence(s)

AA910381, AB071705, DC370097

Consensus CDS

CCDS5422.1

UniProtKB/Swiss-Prot

A8K0E9, B4DHM0, B4DIP5, C9JPG0, Q12765, Q25QX7, Q8IWD1

UniProtKB/TrEMBL

A0A090N7T9

Related

ENSP00000242059.5, ENST00000242059.10

Conserved Domains (1) summary

cl00467
Location:18 → 227

Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...