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HDAC4 histone deacetylase 4 [ Homo sapiens (human) ]

Gene ID: 9759, updated on 14-Nov-2024

Summary

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Official Symbol
HDAC4provided by HGNC
Official Full Name
histone deacetylase 4provided by HGNC
Primary source
HGNC:HGNC:14063
See related
Ensembl:ENSG00000068024 MIM:605314; AllianceGenome:HGNC:14063
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HD4; AHO3; BDMR; HDACA; HA6116; HDAC-4; HDAC-A; NEDCHF; NEDCHID
Summary
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 2.4), testis (RPKM 1.6) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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See HDAC4 in Genome Data Viewer
Location:
2q37.3
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (239048168..239401649, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (239539541..239892233, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (239969864..240323343, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:239757217-239757726 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:239757727-239758237 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_57450 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_57458 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:239764522-239764712 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:239765771-239766270 Neighboring gene Sharpr-MPRA regulatory region 8511 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:239773413-239774030 Neighboring gene NANOG hESC enhancer GRCh37_chr2:239781475-239781979 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:239798834-239799355 Neighboring gene twist family bHLH transcription factor 2 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_57501 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_57510 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:239864003-239864503 Neighboring gene long intergenic non-protein coding RNA 1940 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:239906676-239907658 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:239907659-239908639 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_57531 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:239936997-239937826 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:239957575-239958194 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:239989039-239989540 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:239989541-239990040 Neighboring gene microRNA 4440 Neighboring gene uncharacterized LOC124908009 Neighboring gene microRNA 4441 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240111156-240111673 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240111674-240112190 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240112520-240113118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240117946-240118446 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240123022-240123588 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240134871-240135376 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240136104-240136802 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240136803-240137501 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240146814-240147708 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240152211-240152711 Neighboring gene uncharacterized LOC85009 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240153455-240153994 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240165567-240166264 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:240168807-240170006 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240174119-240174620 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240183749-240184248 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240185799-240186466 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17384 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17385 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240194739-240195516 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17386 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:240197413-240197621 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240212885-240213414 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240213415-240213946 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12499 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:240217222-240217838 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240217839-240218454 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17387 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240229260-240229906 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240232601-240233101 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:240274162-240274355 Neighboring gene microRNA 4269 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240287637-240288172 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240287100-240287636 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17388 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17389 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240307588-240308438 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12500 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12501 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12502 Neighboring gene microRNA 2467 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12503 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17390 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240328963-240329914 Neighboring gene HDAC4 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240397877-240398834 Neighboring gene uncharacterized LOC124908011 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240423087-240423588 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240423589-240424088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240427462-240428150 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240441589-240442260 Neighboring gene uncharacterized LOC124908012

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NEDD9 is transcriptionally regulated by HDAC4 and promotes breast cancer metastasis and macrophage M2 polarization via the FAK/NF-kappaB signaling pathway.
    Title: NEDD9 is transcriptionally regulated by HDAC4 and promotes breast cancer metastasis and macrophage M2 polarization via the FAK/NF-κB signaling pathway.
  2. Interference with Histone Deacetylase 4 Regulates c-Jun N-terminal Kinase/Activating Protein-1 Signaling to Ameliorate Sepsis-induced Alveolar Epithelial Cell Injury.
    Title: Interference with Histone Deacetylase 4 Regulates c-Jun N-terminal Kinase/Activating Protein-1 Signaling to Ameliorate Sepsis-induced Alveolar Epithelial Cell Injury.
  3. HDAC4 influences the DNA damage response and counteracts senescence by assembling with HDAC1/HDAC2 to control H2BK120 acetylation and homology-directed repair.
    Title: HDAC4 influences the DNA damage response and counteracts senescence by assembling with HDAC1/HDAC2 to control H2BK120 acetylation and homology-directed repair.
  4. Targeting SIK3 to modulate hippocampal synaptic plasticity and cognitive function by regulating the transcription of HDAC4 in a mouse model of Alzheimer's disease.
    Title: Targeting SIK3 to modulate hippocampal synaptic plasticity and cognitive function by regulating the transcription of HDAC4 in a mouse model of Alzheimer's disease.
  5. Structural insights into the HDAC4-MEF2A-DNA complex and its implication in long-range transcriptional regulation.
    Title: Structural insights into the HDAC4-MEF2A-DNA complex and its implication in long-range transcriptional regulation.
  6. ZIP4 upregulation aggravates nucleus pulposus cell degradation by promoting inflammation and oxidative stress by mediating the HDAC4-FoxO3a axis.
    Title: ZIP4 upregulation aggravates nucleus pulposus cell degradation by promoting inflammation and oxidative stress by mediating the HDAC4-FoxO3a axis.
  7. HDAC4 regulates the proliferation, migration, and invasion of trophoblasts in pre-eclampsia through the miR-134-5p/FOXM1 axis.
    Title: HDAC4 regulates the proliferation, migration, and invasion of trophoblasts in pre-eclampsia through the miR-134-5p/FOXM1 axis.
  8. Association between circHIPK3/miR-378a-3p/HDAC4 axis and osteoporotic fractures: A comprehensive investigation.
    Title: Association between circHIPK3/miR-378a-3p/HDAC4 axis and osteoporotic fractures: A comprehensive investigation.
  9. Candidate Oligo Therapeutic Target, miR-330-3p, Induces Tamoxifen Resistance in Estrogen Receptor-Positive Breast Cancer Cells via HDAC4.
    Title: Candidate Oligo Therapeutic Target, miR-330-3p, Induces Tamoxifen Resistance in Estrogen Receptor-Positive Breast Cancer Cells via HDAC4.
  10. LncRNA CASC11 upregulation promotes HDAC4 to alleviate oxidized low-density lipoprotein-induced injury of cardiac microvascular endothelial cells.
    Title: LncRNA CASC11 upregulation promotes HDAC4 to alleviate oxidized low-density lipoprotein-induced injury of cardiac microvascular endothelial cells.
Submit: New GeneRIF Correction See all GeneRIFs (180)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Chromosome 2q37 deletion syndrome
MedGen: C2931817 OMIM: 600430 GeneReviews: Not available
Compare labs
Neurodevelopmental disorder with central hypotonia and dysmorphic facies
MedGen: C5676944 OMIM: 619797 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2024-07-16)

ClinGen Genome Curation Page
Haploinsufficency

Little evidence for dosage pathogenicity (Last evaluated 2024-07-16)

ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
EBI GWAS Catalog
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
EBI GWAS Catalog
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
EBI GWAS Catalog
Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
reverse transcriptase gag-pol Amino acid starvation-dependent HDAC4 downregulation leads to HIV-1 transcriptional activation and RT activity production in T-lymphocytes PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0288

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables SUMO transferase activity EXP
Inferred from Experiment
more info
 PubMed 
enables histone H3K14 deacetylase activity, hydrolytic mechanism IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K4 deacetylase activity, hydrolytic mechanism IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K9 deacetylase activity, hydrolytic mechanism IEA
Inferred from Electronic Annotation
more info
  
enables histone H4K12 deacetylase activity, hydrolytic mechanism IEA
Inferred from Electronic Annotation
more info
  
enables histone H4K16 deacetylase activity, hydrolytic mechanism IEA
Inferred from Electronic Annotation
more info
  
enables histone H4K5 deacetylase activity, hydrolytic mechanism IEA
Inferred from Electronic Annotation
more info
  
enables histone H4K8 deacetylase activity, hydrolytic mechanism IEA
Inferred from Electronic Annotation
more info
  
contributes_to histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone deacetylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone deacetylase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables molecular adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables potassium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein lysine deacetylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein lysine deacetylase activity TAS
Traceable Author Statement
more info
  
contributes_to transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell activation TAS
Traceable Author Statement
more info
 PubMed 
involved_in B cell differentiation TAS
Traceable Author Statement
more info
 PubMed 
involved_in cardiac muscle hypertrophy in response to stress TAS
Traceable Author Statement
more info
 PubMed 
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in epigenetic regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inflammatory response TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of gene expression, epigenetic IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of gene expression, epigenetic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of glycolytic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of myotube differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by competitive promoter binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nervous system development TAS
Traceable Author Statement
more info
 PubMed 
involved_in peptidyl-lysine deacetylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein sumoylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein deacetylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein sumoylation TAS
Traceable Author Statement
more info
  
involved_in regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to denervation involved in regulation of muscle adaptation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to interleukin-1 IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in type I interferon-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
part_of histone deacetylase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of histone deacetylase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription repressor complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
histone deacetylase 4
Names
histone deacetylase A
NP_001365343.1
NP_001365344.1
NP_001365345.1
NP_001365346.1
NP_006028.2
XP_006712940.1
XP_006712943.1
XP_011510519.1
XP_011510520.1
XP_011510521.1
XP_011510522.1
XP_011510524.1
XP_011510525.1
XP_011510526.1
XP_011510527.1
XP_011510528.1
XP_011510529.1
XP_016860883.1
XP_024309025.1
XP_047302432.1
XP_047302433.1
XP_047302434.1
XP_047302435.1
XP_047302436.1
XP_047302437.1
XP_047302438.1
XP_047302439.1
XP_047302440.1
XP_047302441.1
XP_047302442.1
XP_047302443.1
XP_047302444.1
XP_047302445.1
XP_047302446.1
XP_047302447.1
XP_047302448.1
XP_047302449.1
XP_047302450.1
XP_047302451.1
XP_047302452.1
XP_047302453.1
XP_047302454.1
XP_054200697.1
XP_054200698.1
XP_054200699.1
XP_054200700.1
XP_054200701.1
XP_054200702.1
XP_054200703.1
XP_054200704.1
XP_054200705.1
XP_054200706.1
XP_054200707.1
XP_054200708.1
XP_054200709.1
XP_054200710.1
XP_054200711.1
XP_054200712.1
XP_054200713.1
XP_054200714.1
XP_054200715.1
XP_054200716.1
XP_054200717.1
XP_054200718.1
XP_054200719.1
XP_054200720.1
XP_054200721.1
XP_054200722.1
XP_054200723.1
XP_054200724.1
XP_054200725.1
XP_054200726.1
XP_054200727.1
XP_054200728.1
XP_054200729.1
XP_054200730.1
XP_054200731.1
XP_054200732.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009235.2 RefSeqGene

    Range
    5629..358481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001378414.1 → NP_001365343.1  histone deacetylase 4 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC017028, AC062017
    Consensus CDS
    CCDS92981.1
    UniProtKB/TrEMBL
    A0A7I2SVS4, Q53SM2
    Related
    ENSP00000440481.3, ENST00000543185.6
    Conserved Domains (2) summary
    cd10162
    Location:91 → 152
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:654 → 1062
    HDAC4; Histone deacetylase 4

  2. NM_001378415.1 → NP_001365344.1  histone deacetylase 4 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC017028, AC062017
    Consensus CDS
    CCDS92981.1
    UniProtKB/TrEMBL
    A0A7I2SVS4, Q53SM2
    Conserved Domains (2) summary
    cd10162
    Location:91 → 152
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:654 → 1062
    HDAC4; Histone deacetylase 4

  3. NM_001378416.1 → NP_001365345.1  histone deacetylase 4 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC017028, AC062017
    Consensus CDS
    CCDS2529.1
    UniProtKB/Swiss-Prot
    E9PGB9, F5GX36, P56524, Q86YH7, Q9UND6
    UniProtKB/TrEMBL
    Q53SM2
    Conserved Domains (2) summary
    cd10162
    Location:91 → 152
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:649 → 1057
    HDAC4; Histone deacetylase 4

  4. NM_001378417.1 → NP_001365346.1  histone deacetylase 4 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC017028, AC062017
    Consensus CDS
    CCDS2529.1
    UniProtKB/Swiss-Prot
    E9PGB9, F5GX36, P56524, Q86YH7, Q9UND6
    UniProtKB/TrEMBL
    Q53SM2
    Conserved Domains (2) summary
    cd10162
    Location:91 → 152
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:649 → 1057
    HDAC4; Histone deacetylase 4

  5. NM_006037.4 → NP_006028.2  histone deacetylase 4 isoform 2

    See identical proteins and their annotated locations for NP_006028.2

    Status: REVIEWED

    Source sequence(s)
    AC017028, AC062017
    Consensus CDS
    CCDS2529.1
    UniProtKB/Swiss-Prot
    E9PGB9, F5GX36, P56524, Q86YH7, Q9UND6
    UniProtKB/TrEMBL
    Q53SM2
    Related
    ENSP00000264606.3, ENST00000345617.7
    Conserved Domains (2) summary
    cd10162
    Location:91 → 152
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:649 → 1057
    HDAC4; Histone deacetylase 4

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    239048168..239401649 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047446489.1 → XP_047302445.1  histone deacetylase 4 isoform X20

  2. XM_047446486.1 → XP_047302442.1  histone deacetylase 4 isoform X17

  3. XM_047446483.1 → XP_047302439.1  histone deacetylase 4 isoform X14

  4. XM_047446498.1 → XP_047302454.1  histone deacetylase 4 isoform X29

  5. XM_047446491.1 → XP_047302447.1  histone deacetylase 4 isoform X21

  6. XM_047446490.1 → XP_047302446.1  histone deacetylase 4 isoform X20

  7. XM_011512226.3 → XP_011510528.1  histone deacetylase 4 isoform X17

    UniProtKB/TrEMBL
    Q53SM2
    Conserved Domains (2) summary
    cd10162
    Location:67 → 128
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:630 → 1038
    HDAC4; Histone deacetylase 4

  8. XM_047446496.1 → XP_047302452.1  histone deacetylase 4 isoform X27

  9. XM_047446493.1 → XP_047302449.1  histone deacetylase 4 isoform X24

  10. XM_047446494.1 → XP_047302450.1  histone deacetylase 4 isoform X25

  11. XM_047446492.1 → XP_047302448.1  histone deacetylase 4 isoform X22

  12. XM_047446482.1 → XP_047302438.1  histone deacetylase 4 isoform X14

  13. XM_047446480.1 → XP_047302436.1  histone deacetylase 4 isoform X10

  14. XM_047446479.1 → XP_047302435.1  histone deacetylase 4 isoform X9

    UniProtKB/Swiss-Prot
    E9PGB9, F5GX36, P56524, Q86YH7, Q9UND6

  15. XM_011512223.3 → XP_011510525.1  histone deacetylase 4 isoform X6

    See identical proteins and their annotated locations for XP_011510525.1

    UniProtKB/TrEMBL
    A0A7I2SVS4, Q53SM2
    Conserved Domains (2) summary
    cd10162
    Location:91 → 152
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:654 → 1062
    HDAC4; Histone deacetylase 4

  16. XM_011512222.4 → XP_011510524.1  histone deacetylase 4 isoform X6

    See identical proteins and their annotated locations for XP_011510524.1

    UniProtKB/TrEMBL
    A0A7I2SVS4, Q53SM2
    Conserved Domains (2) summary
    cd10162
    Location:91 → 152
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:654 → 1062
    HDAC4; Histone deacetylase 4

  17. XM_047446484.1 → XP_047302440.1  histone deacetylase 4 isoform X14

  18. XM_047446476.1 → XP_047302432.1  histone deacetylase 4 isoform X6

    UniProtKB/TrEMBL
    A0A7I2SVS4

  19. XM_006712880.4 → XP_006712943.1  histone deacetylase 4 isoform X19

    See identical proteins and their annotated locations for XP_006712943.1

    UniProtKB/TrEMBL
    Q53SM2
    Conserved Domains (2) summary
    cd10162
    Location:64 → 125
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:627 → 1035
    HDAC4; Histone deacetylase 4

  20. XM_047446487.1 → XP_047302443.1  histone deacetylase 4 isoform X18

  21. XM_017005394.2 → XP_016860883.1  histone deacetylase 4 isoform X16

    UniProtKB/TrEMBL
    Q53SM2

  22. XM_011512219.3 → XP_011510521.1  histone deacetylase 4 isoform X4

    UniProtKB/TrEMBL
    Q53SM2
    Conserved Domains (2) summary
    cd10162
    Location:115 → 176
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:673 → 1076
    HDAC4; Histone deacetylase 4

  23. XM_006712877.4 → XP_006712940.1  histone deacetylase 4 isoform X2

    UniProtKB/TrEMBL
    Q53SM2
    Conserved Domains (2) summary
    cd10162
    Location:115 → 176
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:673 → 1081
    HDAC4; Histone deacetylase 4

  24. XM_011512218.3 → XP_011510520.1  histone deacetylase 4 isoform X3

    UniProtKB/TrEMBL
    Q53SM2
    Conserved Domains (2) summary
    cd10162
    Location:115 → 176
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:678 → 1081
    HDAC4; Histone deacetylase 4

  25. XM_011512217.3 → XP_011510519.1  histone deacetylase 4 isoform X1

    UniProtKB/TrEMBL
    Q53SM2
    Conserved Domains (2) summary
    cd10162
    Location:115 → 176
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:678 → 1086
    HDAC4; Histone deacetylase 4

  26. XM_047446481.1 → XP_047302437.1  histone deacetylase 4 isoform X12

  27. XM_047446478.1 → XP_047302434.1  histone deacetylase 4 isoform X8

  28. XM_047446477.1 → XP_047302433.1  histone deacetylase 4 isoform X7

  29. XM_011512220.3 → XP_011510522.1  histone deacetylase 4 isoform X5

    UniProtKB/TrEMBL
    Q53SM2
    Conserved Domains (2) summary
    cd10162
    Location:92 → 153
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:655 → 1063
    HDAC4; Histone deacetylase 4

  30. XM_047446497.1 → XP_047302453.1  histone deacetylase 4 isoform X28

  31. XM_047446495.1 → XP_047302451.1  histone deacetylase 4 isoform X26

  32. XM_011512225.3 → XP_011510527.1  histone deacetylase 4 isoform X13

    UniProtKB/TrEMBL
    Q53SM2
    Conserved Domains (2) summary
    cd10162
    Location:86 → 147
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:644 → 1052
    HDAC4; Histone deacetylase 4

  33. XM_047446485.1 → XP_047302441.1  histone deacetylase 4 isoform X15

  34. XM_011512224.3 → XP_011510526.1  histone deacetylase 4 isoform X11

    UniProtKB/TrEMBL
    Q53SM2
    Conserved Domains (2) summary
    cd10162
    Location:86 → 147
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:649 → 1057
    HDAC4; Histone deacetylase 4

  35. XM_047446488.1 → XP_047302444.1  histone deacetylase 4 isoform X19

  36. XM_024453257.2 → XP_024309025.1  histone deacetylase 4 isoform X19

    UniProtKB/TrEMBL
    Q53SM2
    Conserved Domains (2) summary
    cd10162
    Location:64 → 125
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:627 → 1035
    HDAC4; Histone deacetylase 4

  37. XM_011512227.3 → XP_011510529.1  histone deacetylase 4 isoform X23

    UniProtKB/TrEMBL
    Q53SM2
    Conserved Domains (2) summary
    cd10162
    Location:43 → 104
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:606 → 1014
    HDAC4; Histone deacetylase 4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    239539541..239892233 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054344746.1 → XP_054200721.1  histone deacetylase 4 isoform X20

  2. XM_054344742.1 → XP_054200717.1  histone deacetylase 4 isoform X17

  3. XM_054344737.1 → XP_054200712.1  histone deacetylase 4 isoform X14

  4. XM_054344756.1 → XP_054200731.1  histone deacetylase 4 isoform X29

  5. XM_054344748.1 → XP_054200723.1  histone deacetylase 4 isoform X21

  6. XM_054344747.1 → XP_054200722.1  histone deacetylase 4 isoform X20

  7. XM_054344741.1 → XP_054200716.1  histone deacetylase 4 isoform X17

  8. XM_054344754.1 → XP_054200729.1  histone deacetylase 4 isoform X27

  9. XM_054344751.1 → XP_054200726.1  histone deacetylase 4 isoform X24

  10. XM_054344752.1 → XP_054200727.1  histone deacetylase 4 isoform X25

  11. XM_054344749.1 → XP_054200724.1  histone deacetylase 4 isoform X22

  12. XM_054344736.1 → XP_054200711.1  histone deacetylase 4 isoform X14

  13. XM_054344732.1 → XP_054200707.1  histone deacetylase 4 isoform X10

  14. XM_054344728.1 → XP_054200703.1  histone deacetylase 4 isoform X6

    UniProtKB/TrEMBL
    A0A7I2SVS4

  15. XM_054344731.1 → XP_054200706.1  histone deacetylase 4 isoform X9

    UniProtKB/Swiss-Prot
    E9PGB9, F5GX36, P56524, Q86YH7, Q9UND6

  16. XM_054344727.1 → XP_054200702.1  histone deacetylase 4 isoform X6

    UniProtKB/TrEMBL
    A0A7I2SVS4

  17. XM_054344738.1 → XP_054200713.1  histone deacetylase 4 isoform X14

  18. XM_054344743.1 → XP_054200718.1  histone deacetylase 4 isoform X18

  19. XM_054344740.1 → XP_054200715.1  histone deacetylase 4 isoform X16

  20. XM_054344725.1 → XP_054200700.1  histone deacetylase 4 isoform X4

  21. XM_054344724.1 → XP_054200699.1  histone deacetylase 4 isoform X3

  22. XM_054344723.1 → XP_054200698.1  histone deacetylase 4 isoform X2

  23. XM_054344722.1 → XP_054200697.1  histone deacetylase 4 isoform X1

  24. XM_054344734.1 → XP_054200709.1  histone deacetylase 4 isoform X12

  25. XM_054344729.1 → XP_054200704.1  histone deacetylase 4 isoform X7

  26. XM_054344730.1 → XP_054200705.1  histone deacetylase 4 isoform X8

  27. XM_054344726.1 → XP_054200701.1  histone deacetylase 4 isoform X5

  28. XM_054344745.1 → XP_054200720.1  histone deacetylase 4 isoform X19

  29. XM_054344755.1 → XP_054200730.1  histone deacetylase 4 isoform X28

  30. XM_054344753.1 → XP_054200728.1  histone deacetylase 4 isoform X26

  31. XM_054344735.1 → XP_054200710.1  histone deacetylase 4 isoform X13

  32. XM_054344739.1 → XP_054200714.1  histone deacetylase 4 isoform X15

  33. XM_054344733.1 → XP_054200708.1  histone deacetylase 4 isoform X11

  34. XM_054344757.1 → XP_054200732.1  histone deacetylase 4 isoform X19

  35. XM_054344744.1 → XP_054200719.1  histone deacetylase 4 isoform X19

  36. XM_054344750.1 → XP_054200725.1  histone deacetylase 4 isoform X23

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P56524.3 GenPept UniProtKB/Swiss-Prot:P56524

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