Ptges2 prostaglandin E synthase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptges2provided by MGI
Official Full Name: prostaglandin E synthase 2provided by MGI
Primary source: MGI:MGI:1917592
See related: Ensembl:ENSMUSG00000026820 AllianceGenome:MGI:1917592
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gbf1; Pges2; Mpges2; 0610038H10Rik
Summary: The protein encoded by this gene is a Golgi membrane-associated prostaglandin E synthase candidate, which is capable of catalyzing the conversion of prostaglandin H2 to prostaglandin E2 in vitro. However, a study using mice deficient of this gene suggests that this enzyme does not contribute to prostaglandin E2 biosynthesis in vivo. This protein is synthesized as a Golgi membrane-bound protein, but its N-terminal hydrophobic region is cleaved off during protein maturation to produce the predominant soluble truncated form that still retains the enzyme activity. This soluble protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE), possibly via an interaction with CAAAT/enhancer-binding protein-beta. [provided by RefSeq, Oct 2009]
Expression: Ubiquitous expression in adrenal adult (RPKM 50.1), duodenum adult (RPKM 41.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 B; 2 22.09 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (32285902..32292752)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (32395890..32402740)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic or pharmacologic blockade of mPGES-2 attenuates renal lipotoxicity and diabetic kidney disease by targeting Rev-Erbalpha/FABP5 signaling.
Title: Genetic or pharmacologic blockade of mPGES-2 attenuates renal lipotoxicity and diabetic kidney disease by targeting Rev-Erbα/FABP5 signaling.
Targeting mPGES-2 to protect against acute kidney injury via inhibition of ferroptosis dependent on p53.
Title: Targeting mPGES-2 to protect against acute kidney injury via inhibition of ferroptosis dependent on p53.
Inhibition of mPGES-2 ameliorates NASH by activating NR1D1 via heme.
Title: Inhibition of mPGES-2 ameliorates NASH by activating NR1D1 via heme.
mPGES-2 blockade antagonizes beta-cell senescence to ameliorate diabetes by acting on NR4A1.
Title: mPGES-2 blockade antagonizes β-cell senescence to ameliorate diabetes by acting on NR4A1.
mPGES-2 deletion enhanced streptozotocin (STZ)-induced liver toxicity possibly via GLUT2-mediated STZ uptake, independently of diabetes mellitus in mice.
Title: mPGES-2 deletion remarkably enhances liver injury in streptozotocin-treated mice via induction of GLUT2.
increased expression of miR-146a in bone marrow-derived mesenchymal stem cells correlated with inhibition of prostaglandin E2 synthase-2 and inhibition of prostaglandin E2 release.
Title: MicroRNA-146a negatively regulates the immunoregulatory activity of bone marrow stem cells by targeting prostaglandin E2 synthase-2.
PGE(2) protects the pulmonary vasculature from remodeling during allergen-induced pulmonary inflammation
Title: Prostaglandin E(2) exerts homeostatic regulation of pulmonary vascular remodeling in allergic airway inflammation.
This article reviews the involvement of the PGE(2), Wnt, and BMP pathways in the development of gastric cancer.
Title: Prostaglandin E2, Wnt, and BMP in gastric tumor mouse models.
Analysis of the mPGES-2 deficient mouse lines does not substantiate the contention that mPGES-2 is a PGE(2) synthase.
Title: Microsomal prostaglandin E synthase-2 is not essential for in vivo prostaglandin E2 biosynthesis.
Study suggests that in hypertensive mice, there are (a) significant microanatomic variations in the pulmonary, renal, and cardiac distribution and cellular localization of mPGES-2 and no differences in expression between genders.
Title: Pulmonary and cardiorenal cyclooxygenase-1 (COX-1), -2 (COX-2), and microsomal prostaglandin E synthase-1 (mPGES-1) and -2 (mPGES-2) expression in a hypertension model.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ptges2 (e-PCR), detects polymorphism
- UniSTS:546968

RH126618 (e-PCR)
- UniSTS:207317

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 12-hydroxyheptadecatrienoic acid synthase activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables glutathione binding	ISS Inferred from Sequence or Structural Similarity more info
enables heme binding	ISS Inferred from Sequence or Structural Similarity more info
enables lyase activity	ISO Inferred from Sequence Orthology more info
enables lyase activity	ISS Inferred from Sequence or Structural Similarity more info
enables prostaglandin-E synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables prostaglandin-E synthase activity	IEA Inferred from Electronic Annotation more info
enables prostaglandin-E synthase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in lipid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in prostaglandin biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within secretion	IDA Inferred from Direct Assay more info

Component	Evidence Code	Pubs
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: prostaglandin E synthase 2

Names: GATE-binding factor 1; mPGES-2; microsomal prostaglandin E synthase 2

NP_598544.2

EC 5.3.99.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133783.2 → NP_598544.2 prostaglandin E synthase 2

See identical proteins and their annotated locations for NP_598544.2

Status: REVIEWED

Source sequence(s)

AK050616, BE956255, CX221758

Consensus CDS

CCDS15914.1

UniProtKB/Swiss-Prot

A2ASQ2, Q8BWM0, Q99J30

Related

ENSMUSP00000028162.4, ENSMUST00000028162.5

Conserved Domains (3) summary

cd03197
Location:223 → 371

GST_C_mPGES2; C-terminal, alpha helical domain of microsomal Prostaglandin E synthase Type 2

COG0625
Location:101 → 368

GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]

cd03040
Location:100 → 176

GST_N_mPGES2; GST_N family; microsomal Prostaglandin E synthase Type 2 (mPGES2) subfamily; mPGES2 is a membrane-anchored dimeric protein containing a CXXC motif which catalyzes the isomerization of PGH2 to PGE2. Unlike cytosolic PGE synthase (cPGES) and microsomal ...