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CD69 CD69 molecule [ Homo sapiens (human) ]

Gene ID: 969, updated on 14-Nov-2024

Summary

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Official Symbol
CD69provided by HGNC
Official Full Name
CD69 moleculeprovided by HGNC
Primary source
HGNC:HGNC:1694
See related
Ensembl:ENSG00000110848 MIM:107273; AllianceGenome:HGNC:1694
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AIM; EA1; MLR-3; CLEC2C; GP32/28; BL-AC/P26
Summary
This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets. [provided by RefSeq, Aug 2011]
Expression
Biased expression in bone marrow (RPKM 55.9), lymph node (RPKM 41.3) and 13 other tissues See more
Orthologs
all
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Genomic context

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See CD69 in Genome Data Viewer
Location:
12p13.31
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (9752486..9760901, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (9638644..9647057, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (9905082..9913497, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4231 Neighboring gene long intergenic non-protein coding RNA 2390 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5949 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5950 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5951 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5952 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4232 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4233 Neighboring gene C-type lectin like 1, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4234 Neighboring gene CRISPRi-validated cis-regulatory element chr12.520 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5953 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5954 Neighboring gene Sharpr-MPRA regulatory region 11505 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4235 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5955 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5956 Neighboring gene CRISPRi-validated cis-regulatory element chr12.528 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5957 Neighboring gene killer cell lectin like receptor F1 Neighboring gene GCNA pseudogene 1 Neighboring gene C-type lectin domain family 2 member B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Increased expression of CD69 antigen on human peripheral blood natural killer cells in patients with allergic rhinitis. Mohammadi Nejad M, et al. Iran J Allergy Asthma Immunol, 2013 Mar. PMID 23454781
  2. CD69 expression potentially predicts response to bendamustine and its modulation by ibrutinib or idelalisib enhances cytotoxic effect in chronic lymphocytic leukemia. Montraveta A, et al. Oncotarget, 2016 Feb 2. PMID 26701728, Free PMC Article
  3. Src-dependent Syk activation controls CD69-mediated signaling and function on human NK cells. Pisegna S, et al. J Immunol, 2002 Jul 1. PMID 12077230
  4. Transient CD4/CD8 ratio inversion and aberrant immune activation during dengue virus infection. Liu CC, et al. J Med Virol, 2002 Oct. PMID 12210415
  5. Lower apoptosis rate and higher CD69 expression in neutrophils from atopic individuals. Nopp A, et al. Inflamm Res, 2002 Nov. PMID 12540017

See all (100) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The heterogeneity of tumour immune microenvironment revealing the CRABP2/CD69 signature discriminates distinct clinical outcomes in breast cancer.
    Title: The heterogeneity of tumour immune microenvironment revealing the CRABP2/CD69 signature discriminates distinct clinical outcomes in breast cancer.
  2. Cancer cell-derived CD69 induced under lipid and oxygen starvation promotes ovarian cancer progression through fibronectin.
    Title: Cancer cell-derived CD69 induced under lipid and oxygen starvation promotes ovarian cancer progression through fibronectin.
  3. CD69 serves as a potential diagnostic and prognostic biomarker for hepatocellular carcinoma.
    Title: CD69 serves as a potential diagnostic and prognostic biomarker for hepatocellular carcinoma.
  4. Machine learning links different gene patterns of viral infection to immunosuppression and immune-related biomarkers in severe burns.
    Title: Machine learning links different gene patterns of viral infection to immunosuppression and immune-related biomarkers in severe burns.
  5. Combined assessment of S- and N-specific IL-2 and IL-13 secretion and CD69 neo-expression for discrimination of post-infection and post-vaccination cellular SARS-CoV-2-specific immune response.
    Title: Combined assessment of S- and N-specific IL-2 and IL-13 secretion and CD69 neo-expression for discrimination of post-infection and post-vaccination cellular SARS-CoV-2-specific immune response.
  6. CD4+ T cells in inflammatory diseases: pathogenic T-helper cells and the CD69-Myl9 system.
    Title: CD4+ T cells in inflammatory diseases: pathogenic T-helper cells and the CD69-Myl9 system.
  7. Apoptosis inhibitor of macrophage as a biomarker for disease activity in Japanese children with IgA nephropathy and Henoch-Schonlein purpura nephritis.
    Title: Apoptosis inhibitor of macrophage as a biomarker for disease activity in Japanese children with IgA nephropathy and Henoch-Schönlein purpura nephritis.
  8. Prognostic Relevance of Concordant Expression CD69 and CD56 in Response to Bortezomib Combination Therapy in Multiple Myeloma Patients.
    Title: Prognostic Relevance of Concordant Expression CD69 and CD56 in Response to Bortezomib Combination Therapy in Multiple Myeloma Patients.
  9. T cells selectively filter oscillatory signals on the minutes timescale.
    Title: T cells selectively filter oscillatory signals on the minutes timescale.
  10. Increased CD69 expression on activated eosinophils in eosinophilic chronic rhinosinusitis correlates with clinical findings.
    Title: Increased CD69 expression on activated eosinophils in eosinophilic chronic rhinosinusitis correlates with clinical findings.
Submit: New GeneRIF Correction See all GeneRIFs (61)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
EBI GWAS Catalog

Variation

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See Variation Viewer (GRCh37.p13)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 significantly inhibits CD69 expression in phytohemagglutinin-stimulated T cells in vitro and may also affect T-cell activation in vivo PubMed
Nef nef Cells expressing HIV-1 Nef from long-term non-progressors and progressive infection patients induce higher surface levels of CD69 and CD25 than cells producing HIV-2 or SIV Nef PubMed
nef HIV-1 Nef protein with an intact SH3-binding domain expressed in the productively infected monocyte-derived macrophages is required for the enhanced expression of CD69 on the cell surface PubMed
nef Functional Nef is required for the activation of resting CD4+ T cells by upregulating CD69 expression on cell surface PubMed
nef HIV-1 Nef downregulates CD69 in Jurkat cells in a concentration-dependent manner PubMed
nef HIV-1 Nef blocks a receptor-proximal event in CD3 signaling by downregulating CD69 expression on the cell surface; mutations at amino acid residues P72, P75, R105 and R106 in Nef disrupts the ability of Nef to block CD3 signaling PubMed
Tat tat HIV-1 Tat binds to a cell surface receptor and activates a cell surface-mediated signal pathway in K562 cells, leading to the activation of NF-kappa B and the induction of CD69 PubMed
Vpr vpr Human endothelial cell (EC)-stimulated virus-producing cells (p24(high) T cells) are activated to sometimes express CD69 (but not CD25, HLA-DR, VLA-1, or effector cytokines) in the presence of HIV-1 Vpr PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables molecular sequestering activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane signaling receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of T cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of T-helper 17 cell lineage commitment IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
early activation antigen CD69
Names
C-type lectin domain family 2, member C
CD69 antigen (p60, early T-cell activation antigen)
activation inducer molecule (AIM/CD69)
early T-cell activation antigen p60
early lymphocyte activation antigen
leukocyte surface antigen Leu-23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001781.2 → NP_001772.1  early activation antigen CD69

    See identical proteins and their annotated locations for NP_001772.1

    Status: REVIEWED

    Source sequence(s)
    AC007068, Z22576
    Consensus CDS
    CCDS8604.1
    UniProtKB/Swiss-Prot
    Q07108
    UniProtKB/TrEMBL
    B4E009, Q53ZX0
    Related
    ENSP00000228434.3, ENST00000228434.7
    Conserved Domains (1) summary
    cd03593
    Location:85 → 196
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    9752486..9760901 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    9638644..9647057 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_026671.1: Suppressed sequence

    Description
    NR_026671.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.

  2. NR_026672.1: Suppressed sequence

    Description
    NR_026672.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07108.1 GenPept UniProtKB/Swiss-Prot:Q07108

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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