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CHD1L chromodomain helicase DNA binding protein 1 like [ Homo sapiens (human) ]

Gene ID: 9557, updated on 14-Nov-2024

Summary

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Official Symbol
CHD1Lprovided by HGNC
Official Full Name
chromodomain helicase DNA binding protein 1 likeprovided by HGNC
Primary source
HGNC:HGNC:1916
See related
Ensembl:ENSG00000131778 MIM:613039; AllianceGenome:HGNC:1916
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALC1; CHDL
Summary
This gene encodes a DNA helicase protein involved in DNA repair. The protein converts ATP to add poly(ADP-ribose) as it regulates chromatin relaxation following DNA damage. Overexpression of this gene has been linked to several types of cancers. [provided by RefSeq, Feb 2017]
Expression
Ubiquitous expression in testis (RPKM 13.4), bone marrow (RPKM 10.4) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See CHD1L in Genome Data Viewer
Location:
1q21.1
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (147172747..147295762)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (147512572..147635662, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (146644326..146767443)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NBPF member 13, pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:146633127-146634326 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1277 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1278 Neighboring gene protein kinase AMP-activated non-catalytic subunit beta 2 Neighboring gene protein disulfide isomerase family A member 3 pseudogene 1 Neighboring gene flavin containing dimethylaniline monoxygenase 5 Neighboring gene chaperonin containing TCP1 subunit 8 pseudogene 1 Neighboring gene HNF4 motif-containing MPRA enhancer 9 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1279 Neighboring gene ribosomal protein L7a pseudogene 15 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:146764440-146765639 Neighboring gene prostaglandin reductase 1 pseudogene Neighboring gene MPRA-validated peak402 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:146807941-146808527 Neighboring gene long intergenic non-protein coding RNA 624 Neighboring gene olfactory receptor family 13 subfamily Z member 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. CHD1L contributes to cisplatin resistance by upregulating the ABCB1-NF-κB axis in human non-small-cell lung cancer. Li Y, et al. Cell Death Dis, 2019 Feb 4. PMID 30718500, Free PMC Article
  2. Structural basis of ALC1/CHD1L autoinhibition and the mechanism of activation by the nucleosome. Wang L, et al. Nat Commun, 2021 Jul 1. PMID 34210977, Free PMC Article
  3. Presence of CHD1L over-expression is associated with aggressive tumor biology and is a novel prognostic biomarker for patient survival in human breast cancer. Wu J, et al. PLoS One, 2014. PMID 25153161, Free PMC Article
  4. Suppressing CHD1L reduces the proliferation and chemoresistance in osteosarcoma. Fan GT, et al. Biochem Biophys Res Commun, 2021 May 21. PMID 33813077
  5. The high expression of CHD1L and its clinical significance in human solid tumors: A meta-analysis. Zhang L, et al. Medicine (Baltimore), 2021 Mar 12. PMID 33725840, Free PMC Article

See all (107) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification and functional characteristics of CHD1L gene variants implicated in human Mullerian duct anomalies.
    Title: Identification and functional characteristics of CHD1L gene variants implicated in human Müllerian duct anomalies.
  2. Host genetic variation at a locus near CHD1L impacts HIV sequence diversity in a South African population.
    Title: Host genetic variation at a locus near CHD1L impacts HIV sequence diversity in a South African population.
  3. The chromatin remodeler ALC1 underlies resistance to PARP inhibitor treatment.
    Title: The chromatin remodeler ALC1 underlies resistance to PARP inhibitor treatment.
  4. Chromodomain Helicase DNA Binding Protein 1-like, a negative regulator of Forkhead box O3a, promotes the proliferation and migration of Angiotensin II-induced vascular smooth muscle cells.
    Title: Chromodomain Helicase DNA Binding Protein 1-like, a negative regulator of Forkhead box O3a, promotes the proliferation and migration of Angiotensin II-induced vascular smooth muscle cells.
  5. Genome-wide scanning for CHD1L gene in papillary thyroid carcinoma complicated with type 2 diabetes mellitus.
    Title: Genome-wide scanning for CHD1L gene in papillary thyroid carcinoma complicated with type 2 diabetes mellitus.
  6. CHD1L prevents lipopolysaccharide-induced hepatocellular carcinomar cell death by activating hnRNP A2/B1-nmMYLK axis.
    Title: CHD1L prevents lipopolysaccharide-induced hepatocellular carcinomar cell death by activating hnRNP A2/B1-nmMYLK axis.
  7. CHD1L augments autophagy-mediated migration of hepatocellular carcinoma through targeting ZKSCAN3.
    Title: CHD1L augments autophagy-mediated migration of hepatocellular carcinoma through targeting ZKSCAN3.
  8. Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling.
    Title: Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling.
  9. Multiple roles for PARP1 in ALC1-dependent nucleosome remodeling.
    Title: Multiple roles for PARP1 in ALC1-dependent nucleosome remodeling.
  10. Mechanistic Insights into Regulation of the ALC1 Remodeler by the Nucleosome Acidic Patch.
    Title: Mechanistic Insights into Regulation of the ALC1 Remodeler by the Nucleosome Acidic Patch.
Submit: New GeneRIF Correction See all GeneRIFs (51)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated 2018-08-30)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated 2018-08-30)

ClinGen Genome Curation Page

EBI GWAS Catalog

Description
A genome-wide association study identifies protein quantitative trait loci (pQTLs).
EBI GWAS Catalog
A genome-wide association study in the genetic analysis of idiopathic thrombophilia project suggests sex-specific regulation of mitochondrial DNA levels.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ22530

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ATP-dependent H2AZ histone chaperone activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent H3-H4 histone complex chaperone activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent chromatin remodeler activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA clamp loader activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA helicase activity TAS
Traceable Author Statement
more info
 PubMed 
enables chromatin extrusion motor activity IEA
Inferred from Electronic Annotation
more info
  
enables cohesin loader activity IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables forked DNA-dependent helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables four-way junction helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone reader activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleosome binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables poly-ADP-D-ribose modification-dependent protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded 3'-5' DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA damage response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA repair TAS
Traceable Author Statement
more info
 PubMed 
involved_in chromatin looping IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
is_active_in site of DNA damage IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in site of double-strand break IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
chromodomain-helicase-DNA-binding protein 1-like
Names
amplified in liver cancer 1
amplified in liver cancer protein 1
NP_001243265.1
NP_001243266.1
NP_001243267.1
NP_001335380.1
NP_001335381.1
NP_001335382.1
NP_001335383.1
NP_001335384.1
NP_001335385.1
NP_001335386.1
NP_001335387.1
NP_001335388.1
NP_001335389.1
NP_001335390.1
NP_001335391.1
NP_001335392.1
NP_001335393.1
NP_001335394.1
NP_001335395.1
NP_004275.4
NP_078844.2
XP_024306819.1
XP_047290957.1
XP_054195684.1
XP_054195685.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052905.1 RefSeqGene

    Range
    74491..127569
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001256336.3 → NP_001243265.1  chromodomain-helicase-DNA-binding protein 1-like isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region which results in translation from a downstream start codon, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AC242426
    UniProtKB/TrEMBL
    X5D2E5
    Conserved Domains (5) summary
    PLN03142
    Location:16 → 599
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd00046
    Location:15 → 105
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd03331
    Location:616 → 766
    Macro_Poa1p_like_SNF2; Macro domain, Poa1p_like family, SNF2 subfamily. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ...
    pfam00271
    Location:246 → 359
    Helicase_C; Helicase conserved C-terminal domain
    pfam06936
    Location:546 → 595
    Selenoprotein_S; Selenoprotein S (SelS)

  2. NM_001256337.3 → NP_001243266.1  chromodomain-helicase-DNA-binding protein 1-like isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks several exons in the 5' coding region which results in translation from a downstream start codon, compared to variant 1. The resulting protein (isoform 4) is shorter when it is compared to isoform 1. Variants 4 and 12-22 all encode the same isoform (4).
    Source sequence(s)
    AC242426
    UniProtKB/TrEMBL
    B4DLS6
    Conserved Domains (2) summary
    PLN03142
    Location:1 → 418
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd03331
    Location:435 → 585
    Macro_Poa1p-like_SNF2; macrodomain, Poa1p-like family, SNF2 subfamily

  3. NM_001256338.3 → NP_001243267.1  chromodomain-helicase-DNA-binding protein 1-like isoform 5

    See identical proteins and their annotated locations for NP_001243267.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks several exons in the 5' coding region which results in translation from a downstream start codon, compared to variant 1. The resulting protein (isoform 5) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AC242426
    Consensus CDS
    CCDS58021.1
    UniProtKB/TrEMBL
    B4DLS6
    Related
    ENSP00000358263.3, ENST00000369259.4
    Conserved Domains (2) summary
    cd03331
    Location:512 → 662
    Macro_Poa1p_like_SNF2; Macro domain, Poa1p_like family, SNF2 subfamily. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ...
    cl26465
    Location:44 → 495
    SNF2_N; SNF2 family N-terminal domain

  4. NM_001348451.2 → NP_001335380.1  chromodomain-helicase-DNA-binding protein 1-like isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variant 8, encodes isoform 6.
    Source sequence(s)
    AC241584, AC242426
    Consensus CDS
    CCDS91038.1
    UniProtKB/TrEMBL
    A0A0A0MSH9, X5D2E5
    Conserved Domains (2) summary
    cd03331
    Location:644 → 794
    Macro_Poa1p_like_SNF2; Macro domain, Poa1p_like family, SNF2 subfamily. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ...
    cl26465
    Location:1 → 627
    SNF2_N; SNF2 family N-terminal domain

  5. NM_001348452.2 → NP_001335381.1  chromodomain-helicase-DNA-binding protein 1-like isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variant 7, encodes isoform 6.
    Source sequence(s)
    AC242426
    Consensus CDS
    CCDS91038.1
    UniProtKB/TrEMBL
    A0A0A0MSH9, X5D2E5
    Related
    ENSP00000389031.3, ENST00000431239.6
    Conserved Domains (2) summary
    cd03331
    Location:644 → 794
    Macro_Poa1p_like_SNF2; Macro domain, Poa1p_like family, SNF2 subfamily. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ...
    cl26465
    Location:1 → 627
    SNF2_N; SNF2 family N-terminal domain

  6. NM_001348453.2 → NP_001335382.1  chromodomain-helicase-DNA-binding protein 1-like isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC242426
    UniProtKB/TrEMBL
    X5D2E5
    Conserved Domains (2) summary
    cd03331
    Location:603 → 753
    Macro_Poa1p_like_SNF2; Macro domain, Poa1p_like family, SNF2 subfamily. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ...
    cl26465
    Location:2 → 586
    SNF2_N; SNF2 family N-terminal domain

  7. NM_001348454.2 → NP_001335383.1  chromodomain-helicase-DNA-binding protein 1-like isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC242426
    Consensus CDS
    CCDS91037.1
    UniProtKB/TrEMBL
    A0A0A0MRH8, B4DLS6
    Related
    ENSP00000355100.6, ENST00000361293.10
    Conserved Domains (2) summary
    cd03331
    Location:564 → 714
    Macro_Poa1p_like_SNF2; Macro domain, Poa1p_like family, SNF2 subfamily. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ...
    cl26465
    Location:45 → 547
    SNF2_N; SNF2 family N-terminal domain

  8. NM_001348455.2 → NP_001335384.1  chromodomain-helicase-DNA-binding protein 1-like isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC242426
    UniProtKB/TrEMBL
    B4DLS6
    Conserved Domains (2) summary
    cd03331
    Location:553 → 703
    Macro_Poa1p_like_SNF2; Macro domain, Poa1p_like family, SNF2 subfamily. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ...
    cl26465
    Location:2 → 536
    SNF2_N; SNF2 family N-terminal domain

  9. NM_001348456.2 → NP_001335385.1  chromodomain-helicase-DNA-binding protein 1-like isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 4 and 13-22, encodes isoform 4.
    Source sequence(s)
    AC242426
    UniProtKB/TrEMBL
    B4DLS6
    Conserved Domains (2) summary
    PLN03142
    Location:1 → 418
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd03331
    Location:435 → 585
    Macro_Poa1p-like_SNF2; macrodomain, Poa1p-like family, SNF2 subfamily

  10. NM_001348457.2 → NP_001335386.1  chromodomain-helicase-DNA-binding protein 1-like isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 4, 12, and 14-22, encodes isoform 4.
    Source sequence(s)
    AC242426
    UniProtKB/TrEMBL
    B4DLS6
    Conserved Domains (2) summary
    PLN03142
    Location:1 → 418
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd03331
    Location:435 → 585
    Macro_Poa1p-like_SNF2; macrodomain, Poa1p-like family, SNF2 subfamily

  11. NM_001348458.2 → NP_001335387.1  chromodomain-helicase-DNA-binding protein 1-like isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variants 4, 12-13, and 15-22, encodes isoform 4.
    Source sequence(s)
    AC242426
    UniProtKB/TrEMBL
    B4DLS6
    Conserved Domains (2) summary
    PLN03142
    Location:1 → 418
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd03331
    Location:435 → 585
    Macro_Poa1p-like_SNF2; macrodomain, Poa1p-like family, SNF2 subfamily

  12. NM_001348459.2 → NP_001335388.1  chromodomain-helicase-DNA-binding protein 1-like isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variants 4, 12-14, and 16-22, encodes isoform 4.
    Source sequence(s)
    AC242426
    UniProtKB/TrEMBL
    B4DLS6
    Conserved Domains (2) summary
    PLN03142
    Location:1 → 418
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd03331
    Location:435 → 585
    Macro_Poa1p-like_SNF2; macrodomain, Poa1p-like family, SNF2 subfamily

  13. NM_001348460.2 → NP_001335389.1  chromodomain-helicase-DNA-binding protein 1-like isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variants 4, 12-15, and 17-22, encodes isoform 4.
    Source sequence(s)
    AC242426
    UniProtKB/TrEMBL
    B4DLS6
    Conserved Domains (2) summary
    PLN03142
    Location:1 → 418
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd03331
    Location:435 → 585
    Macro_Poa1p-like_SNF2; macrodomain, Poa1p-like family, SNF2 subfamily

  14. NM_001348461.2 → NP_001335390.1  chromodomain-helicase-DNA-binding protein 1-like isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variants 4, 12-16, and 18-22, encodes isoform 4.
    Source sequence(s)
    AC242426
    UniProtKB/TrEMBL
    B4DLS6
    Conserved Domains (2) summary
    PLN03142
    Location:1 → 418
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd03331
    Location:435 → 585
    Macro_Poa1p-like_SNF2; macrodomain, Poa1p-like family, SNF2 subfamily

  15. NM_001348462.2 → NP_001335391.1  chromodomain-helicase-DNA-binding protein 1-like isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variants 4, 12-17, and 19-22, encodes isoform 4.
    Source sequence(s)
    AC242426
    UniProtKB/TrEMBL
    B4DLS6
    Conserved Domains (2) summary
    PLN03142
    Location:1 → 418
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd03331
    Location:435 → 585
    Macro_Poa1p-like_SNF2; macrodomain, Poa1p-like family, SNF2 subfamily

  16. NM_001348463.2 → NP_001335392.1  chromodomain-helicase-DNA-binding protein 1-like isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19), as well as variants 4, 12-18, and 20-22, encodes isoform 4.
    Source sequence(s)
    AC242426
    UniProtKB/TrEMBL
    B4DLS6
    Conserved Domains (2) summary
    PLN03142
    Location:1 → 418
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd03331
    Location:435 → 585
    Macro_Poa1p-like_SNF2; macrodomain, Poa1p-like family, SNF2 subfamily

  17. NM_001348464.2 → NP_001335393.1  chromodomain-helicase-DNA-binding protein 1-like isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20), as well as variants 4, 12-19 and 21-22, encodes isoform 4.
    Source sequence(s)
    AC242426
    UniProtKB/TrEMBL
    B4DLS6
    Conserved Domains (2) summary
    PLN03142
    Location:1 → 418
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd03331
    Location:435 → 585
    Macro_Poa1p-like_SNF2; macrodomain, Poa1p-like family, SNF2 subfamily

  18. NM_001348465.2 → NP_001335394.1  chromodomain-helicase-DNA-binding protein 1-like isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21), as well as variants 4, 12-20 and 22, encodes isoform 4.
    Source sequence(s)
    AC242426
    UniProtKB/TrEMBL
    B4DLS6
    Conserved Domains (2) summary
    PLN03142
    Location:1 → 418
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd03331
    Location:435 → 585
    Macro_Poa1p-like_SNF2; macrodomain, Poa1p-like family, SNF2 subfamily

  19. NM_001348466.2 → NP_001335395.1  chromodomain-helicase-DNA-binding protein 1-like isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22), as well as variants 4 and 12-21, encodes isoform 4.
    Source sequence(s)
    AC242426
    UniProtKB/TrEMBL
    B4DLS6
    Conserved Domains (2) summary
    PLN03142
    Location:1 → 418
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd03331
    Location:435 → 585
    Macro_Poa1p-like_SNF2; macrodomain, Poa1p-like family, SNF2 subfamily

  20. NM_004284.6 → NP_004275.4  chromodomain-helicase-DNA-binding protein 1-like isoform 1

    See identical proteins and their annotated locations for NP_004275.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC242426
    Consensus CDS
    CCDS927.1
    UniProtKB/Swiss-Prot
    A5YM64, B4DDE1, B5MDZ7, Q53EZ3, Q5VXX7, Q6DD94, Q6PK83, Q86WJ1, Q86XH3, Q96HF7, Q96SP3, Q9BVJ1, Q9NVV8
    UniProtKB/TrEMBL
    X5D2E5
    Related
    ENSP00000358262.4, ENST00000369258.8
    Conserved Domains (2) summary
    cd03331
    Location:716 → 866
    Macro_Poa1p_like_SNF2; Macro domain, Poa1p_like family, SNF2 subfamily. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ...
    cl26465
    Location:46 → 699
    SNF2_N; SNF2 family N-terminal domain

  21. NM_024568.4 → NP_078844.2  chromodomain-helicase-DNA-binding protein 1-like isoform 3

    See identical proteins and their annotated locations for NP_078844.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses a different splice site in the 5' coding region which results in translation from a downstream start codon, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1. Variants 3 and 9 both encode the same isoform (3).
    Source sequence(s)
    AC242426
    UniProtKB/TrEMBL
    X5D2E5
    Conserved Domains (2) summary
    cd03331
    Location:603 → 753
    Macro_Poa1p_like_SNF2; Macro domain, Poa1p_like family, SNF2 subfamily. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ...
    cl26465
    Location:2 → 586
    SNF2_N; SNF2 family N-terminal domain

RNA

  1. NR_046070.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay.(NMD).
    Source sequence(s)
    AC242426
    Related
    ENST00000467213.5

  2. NR_145681.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC242426
    Related
    ENST00000652161.1

  3. NR_145682.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC242426
    Related
    ENST00000650721.1

  4. NR_145683.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC242426
    Related
    ENST00000651410.1

  5. NR_145684.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC242426
    Related
    ENST00000650828.1

  6. NR_145685.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC242426

  7. NR_145686.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC242426
    Related
    ENST00000651407.1

  8. NR_145687.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC242426

  9. NR_145688.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC242426

  10. NR_145689.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC242426
    Related
    ENST00000652616.1

  11. NR_145690.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC242426
    Related
    ENST00000652346.1

  12. NR_145691.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC242426

  13. NR_145692.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC242426
    Related
    ENST00000652494.1

  14. NR_145693.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC242426
    Related
    ENST00000488864.5

  15. NR_145694.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC242426
    Related
    ENST00000652486.1

  16. NR_145695.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC242426
    Related
    ENST00000651207.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    147172747..147295762
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047435001.1 → XP_047290957.1  chromodomain-helicase-DNA-binding protein 1-like isoform X1

  2. XM_024451051.2 → XP_024306819.1  chromodomain-helicase-DNA-binding protein 1-like isoform X2

    UniProtKB/TrEMBL
    A0A494C179
    Related
    ENSP00000498899.1, ENST00000652587.1
    Conserved Domains (2) summary
    cd03331
    Location:289 → 439
    Macro_Poa1p_like_SNF2; Macro domain, Poa1p_like family, SNF2 subfamily. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ...
    cl26465
    Location:1 → 272
    SNF2_N; SNF2 family N-terminal domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    147512572..147635662 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054339710.1 → XP_054195685.1  chromodomain-helicase-DNA-binding protein 1-like isoform X2

  2. XM_054339709.1 → XP_054195684.1  chromodomain-helicase-DNA-binding protein 1-like isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86WJ1.3 GenPept UniProtKB/Swiss-Prot:Q86WJ1

Gene LinkOut

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