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mlrA DNA-binding transcriptional activator MlrA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 949029, updated on 19-Sep-2024

Summary

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Official Symbol
mlrA
Official Full Name
DNA-binding transcriptional activator MlrA
Primary source
ECOCYC:EG12008
Locus tag
b2127
See related
ASAP:ABE-0007030
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2119; yehV
Summary
RpoS regulon. [More information is available at EcoGene: EG12008]. MlrA is a regulator of curli production in an avian pathogenic Escherichia coli strain and in Salmonella enterica serovar Typhimurium . [More information is available at EcoCyc: EG12008].
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Genomic context

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Sequence:
NC_000913.3 (2214866..2215597)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF1456 domain-containing protein YehS Neighboring gene DNA-binding transcriptional dual regulator BtsR Neighboring gene high-affinity pyruvate receptor Neighboring gene UPF0387 family protein YohO Neighboring gene glycine betaine ABC transporter membrane subunit YehW Neighboring gene glycine betaine ABC transporter ATP binding subunit YehX Neighboring gene glycine betaine ABC transporter membrane subunit YehY

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Escherichia coli O157:H7 Shiga toxin-encoding bacteriophages: integrations, excisions, truncations, and evolutionary implications. Shaikh N, et al. J Bacteriol, 2003 Jun. PMID 12775697, Free PMC Article
  2. Phage insertion in mlrA and variations in rpoS limit curli expression and biofilm formation in Escherichia coli serotype O157: H7. Uhlich GA, et al. Microbiology (Reading), 2013 Aug. PMID 23744902
  3. Regulatory role of MlrA in transcription activation of csgD, the master regulator of biofilm formation in Escherichia coli. Ogasawara H, et al. FEMS Microbiol Lett, 2010 Nov. PMID 20874755
  4. MlrA, a novel regulator of curli (AgF) and extracellular matrix synthesis by Escherichia coli and Salmonella enterica serovar Typhimurium. Brown PK, et al. Mol Microbiol, 2001 Jul. PMID 11489123
  5. Insertion site occupancy by stx2 bacteriophages depends on the locus availability of the host strain chromosome. Serra-Moreno R, et al. J Bacteriol, 2007 Sep. PMID 17644594, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA-binding transcriptional activator MlrA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2214866..2215597
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416631.1 DNA-binding transcriptional activator MlrA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416631.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A1V2GE05, A0A5B9AHY1
    Conserved Domains (1) summary
    PRK15043
    Location:1 → 243
    PRK15043; HTH-type transcriptional regulator MlrA
Nucleotide Protein
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