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mscM miniconductance mechanosensitive channel MscM [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948676, updated on 19-Sep-2024

Summary

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Official Symbol
mscM
Official Full Name
miniconductance mechanosensitive channel MscM
Primary source
ECOCYC:G7840
Locus tag
b4159
See related
ASAP:ABE-0013621
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4155; yjeP
Summary
mscS, kefA, yjeP, ybiO, ybdG and ynaI are paralogs. [More information is available at EcoGene: EG12478]. YjeP is a member of the small mechanositive ion channel (MscS) family . [More information is available at EcoCyc: G7840].
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Genomic context

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Sequence:
NC_000913.3 (4386047..4389370, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative transporter YjeM Neighboring gene uncharacterized protein YjeN Neighboring gene DUF2645 domain-containing inner membrane protein YjeO Neighboring gene phosphatidylserine decarboxylase proenzyme Neighboring gene ribosome small subunit-dependent GTPase A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multiple mechanosensitive ion channels from Escherichia coli, activated at different thresholds of applied pressure. Berrier C, et al. J Membr Biol, 1996 May. PMID 8661505
  2. Structural characterization of Escherichia coli phosphatidylserine decarboxylase. Li QX, et al. J Biol Chem, 1988 Aug 15. PMID 3042771
  3. Analysis of the kefA2 mutation suggests that KefA is a cation-specific channel involved in osmotic adaptation in Escherichia coli. McLaggan D, et al. Mol Microbiol, 2002 Jan. PMID 11985727
  4. Protection of Escherichia coli cells against extreme turgor by activation of MscS and MscL mechanosensitive channels: identification of genes required for MscS activity. Levina N, et al. EMBO J, 1999 Apr 1. PMID 10202137, Free PMC Article
  5. Interfering with different steps of protein synthesis explored by transcriptional profiling of Escherichia coli K-12. Sabina J, et al. J Bacteriol, 2003 Oct. PMID 14526028, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables mechanosensitive monoatomic ion channel activity EXP
Inferred from Experiment
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to osmotic stress EXP
Inferred from Experiment
more info
 PubMed 
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 

General protein information

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Preferred Names
miniconductance mechanosensitive channel MscM

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4386047..4389370 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418583.1 miniconductance mechanosensitive channel MscM [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418583.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376FSB2
    Conserved Domains (1) summary
    PRK10929
    Location:1 → 1107
    PRK10929; putative mechanosensitive channel protein; Provisional
Nucleotide Protein
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