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dcuB anaerobic C4-dicarboxylate transporter DcuB [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948641, updated on 10-Oct-2024

Summary

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Official Symbol
dcuB
Official Full Name
anaerobic C4-dicarboxylate transporter DcuB
Primary source
ECOCYC:EG10006
Locus tag
b4123
See related
ASAP:ABE-0013503
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4116; genF
Summary
IT (Ion Transporter) superfamily (Prakash, 2003). [More information is available at EcoGene: EG10006]. The DcuB transporter is one of three transporters known to be responsible for the uptake of C4-dicarboxylates such as fumarate under anaerobic conditions. [More information is available at EcoCyc: EG10006].
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Genomic context

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Sequence:
NC_000913.3 (4347404..4348744, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF2238 domain-containing inner membrane protein YjdF Neighboring gene fumarase B Neighboring gene DNA-binding transcriptional activator DcuR Neighboring gene sensor histidine kinase DcuS Neighboring gene PF06902 family protein YjdI

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Mutational Hotspot and Strong Selection Contribute to the Order of Mutations Selected for during Escherichia coli Adaptation to the Gut. Lourenço M, et al. PLoS Genet, 2016 Nov. PMID 27812114, Free PMC Article
  2. Conversion of the sensor kinase DcuS of Escherichia coli of the DcuB/DcuS sensor complex to the C(4) -dicarboxylate responsive form by the transporter DcuB. Wörner S, et al. Environ Microbiol, 2016 Dec. PMID 27318186
  3. The fumarate/succinate antiporter DcuB of Escherichia coli is a bifunctional protein with sites for regulation of DcuS-dependent gene expression. Kleefeld A, et al. J Biol Chem, 2009 Jan 2. PMID 18957436
  4. Influence of C(4) -Dcu transporters on hydrogenase and formate dehydrogenase activities in stationary phase-grown fermenting Escherichia coli. Karapetyan L, et al. IUBMB Life, 2020 Aug. PMID 32277802
  5. Anaerobic fumarate transport in Escherichia coli by an fnr-dependent dicarboxylate uptake system which is different from the aerobic dicarboxylate uptake system. Engel P, et al. J Bacteriol, 1992 Sep. PMID 1512189, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Influence of C4 -Dcu transporters on hydrogenase and formate dehydrogenase activities in stationary phase-grown fermenting Escherichia coli.
    Title: Influence of C(4) -Dcu transporters on hydrogenase and formate dehydrogenase activities in stationary phase-grown fermenting Escherichia coli.
  2. The relationship of absolute contents of DcuS, DcuB, and DctA to the functional state of DcuS revealed their contribution to the control of DcuS-DcuR in vivo, which was not accessible by other approaches, leading to a revision of previous models.
    Title: Cellular Concentrations of the Transporters DctA and DcuB and the Sensor DcuS of Escherichia coli and the Contributions of Free and Complexed DcuS to Transcriptional Regulation by DcuR.
  3. in vivo competitive assays showed that one of the second steps (focA) exhibited positive epistasis with the first, while another (dcuB) exhibited negative epistasis. The data shows that strong effect adaptive mutations continuously recur in gut commensal bacterial species.
    Title: A Mutational Hotspot and Strong Selection Contribute to the Order of Mutations Selected for during Escherichia coli Adaptation to the Gut.
  4. Deleting both dcuB and dcuC genes resulted in 90% decrease of succinate titer, suggesting that DcuB and DcuC were the main transporters for succinate efflux.
    Title: Activating C4-dicarboxylate transporters DcuB and DcuC for improving succinate production.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables C4-dicarboxylate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables C4-dicarboxylate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables succinate:fumarate antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within C4-dicarboxylate transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in C4-dicarboxylate transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within anaerobic respiration EXP
Inferred from Experiment
more info
 PubMed 
involved_in fumarate transport IEA
Inferred from Electronic Annotation
more info
  
involved_in succinate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
anaerobic C4-dicarboxylate transporter DcuB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4347404..4348744 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418547.1 anaerobic C4-dicarboxylate transporter DcuB [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418547.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7D7KDE4, A0A8S7JZC2, A0AAN5HJ47
    Conserved Domains (1) summary
    PRK12489
    Location:38 → 444
    PRK12489; anaerobic C4-dicarboxylate transporter; Reviewed
Nucleotide Protein
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