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dcuS sensor histidine kinase DcuS [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948639, updated on 19-Sep-2024

Summary

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Official Symbol
dcuS
Official Full Name
sensor histidine kinase DcuS
Primary source
ECOCYC:G7827
Locus tag
b4125
See related
ASAP:ABE-0013509
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4118; yjdH
Summary
dcuSR operon is repressed by nitrate via the NarXL system. [More information is available at EcoGene: EG12465]. DcuS acts as a C4-dicarboxylate-sensing histidine kinase . [More information is available at EcoCyc: G7827].
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Genomic context

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Sequence:
NC_000913.3 (4350031..4351662, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene fumarase B Neighboring gene anaerobic C4-dicarboxylate transporter DcuB Neighboring gene DNA-binding transcriptional activator DcuR Neighboring gene PF06902 family protein YjdI Neighboring gene putative N-acetyltransferase YjdJ

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The nature of the stimulus and of the fumarate binding site of the fumarate sensor DcuS of Escherichia coli. Kneuper H, et al. J Biol Chem, 2005 May 27. PMID 15781452
  2. Properties of transmembrane helix TM1 of the DcuS sensor kinase of Escherichia coli, the stator for TM2 piston signaling. Stopp M, et al. Biol Chem, 2021 Sep 27. PMID 34355547
  3. Simultaneous measurement of protein one-bond residual dipolar couplings without increased resonance overlap. Vijayan V, et al. J Magn Reson, 2005 Jun. PMID 15862241
  4. Citrate sensing by the C4-dicarboxylate/citrate sensor kinase DcuS of Escherichia coli: binding site and conversion of DcuS to a C4-dicarboxylate- or citrate-specific sensor. Krämer J, et al. J Bacteriol, 2007 Jun. PMID 17416661, Free PMC Article
  5. The NMR structure of the sensory domain of the membranous two-component fumarate sensor (histidine protein kinase) DcuS of Escherichia coli. Pappalardo L, et al. J Biol Chem, 2003 Oct 3. PMID 12907689

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Properties of transmembrane helix TM1 of the DcuS sensor kinase of Escherichia coli, the stator for TM2 piston signaling.
    Title: Properties of transmembrane helix TM1 of the DcuS sensor kinase of Escherichia coli, the stator for TM2 piston signaling.
  2. Regulation of Aerobic Succinate Transporter dctA of E. coli by cAMP-CRP, DcuS-DcuR, and EIIAGlc: Succinate as a Carbon Substrate and Signaling Molecule.
    Title: Regulation of Aerobic Succinate Transporter dctA of E. coli by cAMP-CRP, DcuS-DcuR, and EIIAGlc: Succinate as a Carbon Substrate and Signaling Molecule.
  3. Tight Complex Formation of the Fumarate Sensing DcuS-DcuR Two-Component System at the Membrane and Target Promoter Search by Free DcuR Diffusion.
    Title: Tight Complex Formation of the Fumarate Sensing DcuS-DcuR Two-Component System at the Membrane and Target Promoter Search by Free DcuR Diffusion.
  4. The relationship of absolute contents of DcuS, DcuB, and DctA to the functional state of DcuS revealed their contribution to the control of DcuS-DcuR in vivo, which was not accessible by other approaches, leading to a revision of previous models.
    Title: Cellular Concentrations of the Transporters DctA and DcuB and the Sensor DcuS of Escherichia coli and the Contributions of Free and Complexed DcuS to Transcriptional Regulation by DcuR.
  5. DcuS is required for location of DctA and DcuR at the poles and formation of tripartite DctA/DcuS/DcuR sensor/regulator complexes.
    Title: Polar localization of a tripartite complex of the two-component system DcuS/DcuR and the transporter DctA in Escherichia coli depends on the sensor kinase DcuS.
  6. C4-dicarboxylate sensing by DctA/DcuS resides in DcuS, and that DctA serves as an activity switch.
    Title: Differentiation of DctA and DcuS function in the DctA/DcuS sensor complex of Escherichia coli: function of DctA as an activity switch and of DcuS as the C4-dicarboxylate sensor.
  7. Reorganizing the DcuS homodimer and its interaction with DctA activate the kinase.
    Title: The cytoplasmic PASC domain of the sensor kinase DcuS of Escherichia coli: role in signal transduction, dimer formation, and DctA interaction.
  8. It is concluded that DctA forms a functional unit or sensor complex with DcuS through specific interaction sites.
    Title: Interaction of the Escherichia coli transporter DctA with the sensor kinase DcuS: presence of functional DctA/DcuS sensor units.
  9. DcuS/DcuR modulating citA and citB expression.
    Title: CitA/CitB two-component system regulating citrate fermentation in Escherichia coli and its relation to the DcuS/DcuR system in vivo.
  10. The FRET and cross-linking data demonstrate the presence in living cells, in bacterial membranes, and in proteoliposomes of full-length DcuS protein in an oligomeric state, including a tetramer.
    Title: Oligomeric sensor kinase DcuS in the membrane of Escherichia coli and in proteoliposomes: chemical cross-linking and FRET spectroscopy.
Submit: New GeneRIF Correction See all GeneRIFs (15)

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphorelay sensor kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphorelay sensor kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphorelay sensor kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein histidine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein histidine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptidyl-histidine phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorelay signal transduction system IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphorelay signal transduction system IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in outer membrane-bounded periplasmic space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 
part_of protein histidine kinase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
sensor histidine kinase DcuS
NP_418549.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4350031..4351662 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418549.1 sensor histidine kinase DcuS [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418549.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7L7EBX4
    Conserved Domains (1) summary
    PRK11086
    Location:2 → 543
    PRK11086; sensory histidine kinase DcuS; Provisional
Nucleotide Protein
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