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adiC arginine:agmatine antiporter [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948628, updated on 19-Sep-2024

Summary

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Official Symbol
adiC
Official Full Name
arginine:agmatine antiporter
Primary source
ECOCYC:EG12462
Locus tag
b4115
See related
ASAP:ABE-0013473
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4108; yjdD; yjdE
Summary
EvgAS regulon. [More information is available at EcoGene: EG12462]. To survive in extremely acidic environments, Escherichia coli has evolved three acid resistance strategies. [More information is available at EcoCyc: EG12462].
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Genomic context

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Sequence:
NC_000913.3 (4335694..4337031, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene small regulatory membrane protein PmrR Neighboring gene sensor histidine kinase BasS Neighboring gene DNA-binding transcriptional dual regulator BasR Neighboring gene phosphoethanolamine transferase EptA Neighboring gene DNA-binding transcriptional activator AdiY Neighboring gene arginine decarboxylase, degradative

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Unveiling the Mechanism of Arginine Transport through AdiC with Molecular Dynamics Simulations: The Guiding Role of Aromatic Residues. Krammer EM, et al. PLoS One, 2016. PMID 27482712, Free PMC Article
  2. Structure of a prokaryotic virtual proton pump at 3.2 A resolution. Fang Y, et al. Nature, 2009 Aug 20. PMID 19578361, Free PMC Article
  3. Structure and mechanism of an amino acid antiporter. Gao X, et al. Science, 2009 Jun 19. PMID 19478139
  4. Insights into the molecular basis for substrate binding and specificity of the wild-type L-arginine/agmatine antiporter AdiC. Ilgü H, et al. Proc Natl Acad Sci U S A, 2016 Sep 13. PMID 27582465, Free PMC Article
  5. Projection structure of a member of the amino acid/polyamine/organocation transporter superfamily. Casagrande F, et al. J Biol Chem, 2008 Nov 28. PMID 18819925, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables arginine:agmatine antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in carboxylic acid transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular stress response to acidic pH IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in organic cation transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
arginine:agmatine antiporter

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4335694..4337031 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418539.1 arginine:agmatine antiporter [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418539.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A377CEC6
    Conserved Domains (1) summary
    PRK10644
    Location:1 → 445
    PRK10644; arginine/agmatine antiporter
Nucleotide Protein
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