U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

creC sensory histidine kinase CreC [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948609, updated on 19-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
creC
Official Full Name
sensory histidine kinase CreC
Primary source
ECOCYC:EG10730
Locus tag
b4399
See related
ASAP:ABE-0014430
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4391; phoM
Summary
CreC belongs to the two component system CreC/CreB , and is involved in phosphate limitation . [More information is available at EcoCyc: EG10730].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (4636696..4638120)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative phosphatase Neighboring gene DNA-binding transcriptional dual regulator Rob Neighboring gene PF05981 family protein CreA Neighboring gene DNA-binding transcriptional regulator CreB Neighboring gene putative inner membrane protein CreD Neighboring gene DNA-binding transcriptional dual regulator ArcA

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Cloning and characterization of the alkaline phosphatase positive regulatory gene (phoM) of Escherichia coli. Makino K, et al. Mol Gen Genet, 1984. PMID 6381964
  2. The CreC Regulator of Escherichia coli, a New Target for Metabolic Manipulations. Godoy MS, et al. Appl Environ Microbiol, 2016 Jan 1. PMID 26497466, Free PMC Article
  3. Molecular cloning of the wild-type phoM operon in Escherichia coli K-12. Wanner BL, et al. J Bacteriol, 1988 Jan. PMID 3275616, Free PMC Article
  4. Identification of the phoM gene product and its regulation in Escherichia coli K-12. Ludtke D, et al. J Bacteriol, 1984 Jul. PMID 6330029, Free PMC Article
  5. Control of phoR-dependent bacterial alkaline phosphatase clonal variation by the phoM region. Wanner BL. J Bacteriol, 1987 Feb. PMID 3542979, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. work shows that CreC affects both carbon catabolism and the intracellular redox state and influences many different aspects of bacterial physiology
    Title: The CreC Regulator of Escherichia coli, a New Target for Metabolic Manipulations.
  2. CreC showed an interaction with PhoB, before an interaction between PhoB and PhoR, suggesting that this acts as a constant sensor for the early response to phosphate starvation.
    Title: Transcript and protein level analyses of the interactions among PhoB, PhoR, PhoU and CreC in response to phosphate starvation in Escherichia coli.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphorelay sensor kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphorelay sensor kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein histidine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within glycolytic fermentation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in peptidyl-histidine phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphorelay signal transduction system IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
sensory histidine kinase CreC
NP_418816.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4636696..4638120
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418816.1 sensory histidine kinase CreC [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418816.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A3L5H0D1
    Conserved Domains (1) summary
    PRK11100
    Location:1 → 473
    PRK11100; sensory histidine kinase CreC; Provisional
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.