U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

metB O-succinylhomoserine(thiol)-lyase/O-succinylhomoserine lyase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948434, updated on 3-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
metB
Official Full Name
O-succinylhomoserine(thiol)-lyase/O-succinylhomoserine lyase
Primary source
ECOCYC:EG10582
Locus tag
b3939
See related
ASAP:ABE-0012887
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3931; met-1
Summary
Upregulated by GSNO in defined medium. [More information is available at EcoGene: EG10582].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (4128672..4129832)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative lipid-binding hydrolase YiiX Neighboring gene DNA-binding transcriptional repressor MetJ Neighboring gene fused aspartate kinase/homoserine dehydrogenase 2 Neighboring gene 5,10-methylenetetrahydrofolate reductase

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Cloning, purification, crystallization, and preliminary X-ray diffraction analysis of cystathionine gamma-synthase from E. coli. Wahl MC, et al. FEBS Lett, 1997 Sep 15. PMID 9323022
  2. Purification and properties of cystathionine gamma-synthase from overproducing strains of Escherichia coli. Holbrook EL, et al. Biochemistry, 1990 Jan 16. PMID 2405903
  3. Reaction mechanism of Escherichia coli cystathionine gamma-synthase: direct evidence for a pyridoxamine derivative of vinylglyoxylate as a key intermediate in pyridoxal phosphate dependent gamma-elimination and gamma-replacement reactions. Brzović P, et al. Biochemistry, 1990 Jan 16. PMID 2405904
  4. Cystathionine gamma-synthase from Salmonella. Beta elimination and replacement reactions and inhibition by O-succinylserine. Guggenheim S, et al. J Biol Chem, 1969 Jul 10. PMID 4893684
  5. Appendix. Purification, molecular weight, and NH2-terminal sequence of cystathionine gamma-synthase of Escherichia coli. Tran SV, et al. J Biol Chem, 1983 Dec 25. PMID 6361021

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables cystathionine gamma-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cystathionine gamma-synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cystathionine gamma-synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cystathionine gamma-synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyridoxal phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cysteine biosynthetic process via cystathionine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in methionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within methionine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transsulfuration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transsulfuration IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
O-succinylhomoserine(thiol)-lyase/O-succinylhomoserine lyase
NP_418374.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4128672..4129832
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418374.1 O-succinylhomoserine(thiol)-lyase/O-succinylhomoserine lyase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418374.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8H9W088
    Conserved Domains (1) summary
    PRK08045
    Location:1 → 386
    PRK08045; cystathionine gamma-synthase; Provisional
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.