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sodA superoxide dismutase (Mn) [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948403, updated on 19-Sep-2024

Summary

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Official Symbol
sodA
Official Full Name
superoxide dismutase (Mn)
Primary source
ECOCYC:EG10953
Locus tag
b3908
See related
ASAP:ABE-0012761
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3901
Summary
SoxRS regulon. [More information is available at EcoGene: EG10953].
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Genomic context

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Sequence:
NC_000913.3 (4100810..4101430)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional activator RhaS Neighboring gene DNA-binding transcriptional activator RhaR Neighboring gene rhamnose/lyxose:H(+) symporter Neighboring gene 2-dehydro-3-deoxy-D-gluconate:H(+) symporter Neighboring gene 6-hydroxyaminopurine reductase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of regulatory mutations causing anaerobic derepression of the sodA gene in Escherichia coli K12: cooperation between cis- and trans-acting regulatory loci. Beaumont MD, et al. J Gen Microbiol, 1993 Nov. PMID 8277251
  2. Superoxide dismutases of Escherichia coli: intracellular localization and functions. Gregory EM, et al. J Bacteriol, 1973 Sep. PMID 4580575, Free PMC Article
  3. Spectroscopic and computational studies of the azide-adduct of manganese superoxide dismutase: definitive assignment of the ligand responsible for the low-temperature thermochromism. Jackson TA, et al. J Am Chem Soc, 2004 Oct 6. PMID 15453782
  4. Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. Beauchamp C, et al. Anal Biochem, 1971 Nov. PMID 4943714
  5. New class of potent catalysts of O2.-dismutation. Mn(III) ortho-methoxyethylpyridyl- and di-ortho-methoxyethylimidazolylporphyrins. Batinić-Haberle I, et al. Dalton Trans, 2004 Jun 7. PMID 15252564

See all (131) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. WT-MnSOD protein conserves a destabilizing amino acid at position 146 as part of a strategy to favor metal ion binding.
    Title: A Single Outer-Sphere Mutation Stabilizes apo-Mn Superoxide Dismutase by 35 °C and Disfavors Mn Binding.
  2. emphasize the role of residue 66 in catalysis and inhibition and provide a structural explanation for differences in catalytic properties between human and certain bacterial forms of manganese superoxide dismutases
    Title: Structural and kinetic study of differences between human and Escherichia coli manganese superoxide dismutases.
  3. N-terminus verified by Edman degradation on mature peptide
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
  4. Escherichia coli manganese superoxide dismutase has two exponential kinetic processes (fast and slow phases) associated with metal binding
    Title: Kinetic analysis of the metal binding mechanism of Escherichia coli manganese superoxide dismutase.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables antioxidant activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables manganese ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables superoxide dismutase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables superoxide dismutase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables superoxide dismutase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to selenium ion IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in removal of superoxide radicals IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within removal of superoxide radicals IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to acidic pH IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within superoxide metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in superoxide metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
superoxide dismutase (Mn)
NP_418344.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4100810..4101430
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418344.3 superoxide dismutase (Mn) [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418344.3

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A1X3JAC6
    Conserved Domains (1) summary
    PRK10925
    Location:1 → 206
    PRK10925; superoxide dismutase [Mn]
Nucleotide Protein
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