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relB antitoxin/DNA-binding transcriptional repressor RelB [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948308, updated on 19-Sep-2024

Summary

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Official Symbol
relB
Official Full Name
antitoxin/DNA-binding transcriptional repressor RelB
Primary source
ECOCYC:EG10836
Locus tag
b1564
See related
ASAP:ABE-0005224
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1558; RC
Summary
RelB is the antitoxin of the RelE-RelB toxin-antitoxin system . [More information is available at EcoCyc: EG10836].
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Genomic context

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Sequence:
NC_000913.3 (1645633..1645872, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene toxic protein HokD Neighboring gene mRNA interferase toxin RelE Neighboring gene protein YdfV Neighboring gene PF14282 family protein FlxA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evidence that glucose starvation-sensitive mutants are altered in the relB locus. Mosteller RD. J Bacteriol, 1978 Feb. PMID 342488, Free PMC Article
  2. Variations in phenotype of relB mutants of Escherichia coli and the effect of pus and sup mutations. Diderichsen B, et al. Mol Gen Genet, 1980. PMID 6162075
  3. Improved mapping of ksgB and integration of transposons near relB and terC in Escherichia coli. Diderichsen B. J Bacteriol, 1981 Apr. PMID 6260745, Free PMC Article
  4. RelE-mediated dormancy is enhanced at high cell density in Escherichia coli. Tashiro Y, et al. J Bacteriol, 2012 Mar. PMID 22210768, Free PMC Article
  5. Genetics of the relB locus in Escherichia coli. Diderichsen B, et al. J Bacteriol, 1977 Jul. PMID 326765, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Here, the authors report that the transition to dormant states is mediated by one of the major toxin-antitoxin systems, RelEB, in a cell density-dependent manner in Escherichia coli K-12 MG1655.
    Title: RelE-mediated dormancy is enhanced at high cell density in Escherichia coli.
  2. molecular interactions important for transcriptional control of the relBE model operon were characterized.
    Title: RelB and RelE of Escherichia coli form a tight complex that represses transcription via the ribbon-helix-helix motif in RelB.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription repressor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription repressor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables toxin sequestering activity EXP
Inferred from Experiment
more info
 PubMed 
enables transcription cis-regulatory region binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transcription cis-regulatory region binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA-templated transcription EXP
Inferred from Experiment
more info
 PubMed 
involved_in DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of growth NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in single-species biofilm formation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of protein-DNA complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of protein-DNA complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of toxin-antitoxin complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
antitoxin/DNA-binding transcriptional repressor RelB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1645633..1645872 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416082.1 antitoxin/DNA-binding transcriptional repressor RelB [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416082.1

    Status: PROVISIONAL

    Conserved Domains (1) summary
    PRK11235
    Location:1 → 79
    PRK11235; type II toxin-antitoxin system RelB/DinJ family antitoxin
Nucleotide Protein
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