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mioC flavoprotein MioC [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948249, updated on 19-Sep-2024

Summary

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Official Symbol
mioC
Official Full Name
flavoprotein MioC
Primary source
ECOCYC:EG11199
Locus tag
b3742
See related
ASAP:ABE-0012235
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3736; yieB
Summary
DnaA regulon. [More information is available at EcoGene: EG11199]. MioC is a flavoprotein (FMN binding) that is necessary for activity of biotin synthase in an in vitro system . [More information is available at EcoCyc: EG11199].
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Genomic context

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Sequence:
NC_000913.3 (3926012..3926455, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 16S rRNA m(7)G527 methyltransferase Neighboring gene 5-carboxymethylaminomethyluridine-tRNA synthase subunit MnmG Neighboring gene DNA-binding transcriptional dual regulator AsnC Neighboring gene asparagine synthetase A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. MioC and GidA proteins promote cell division in E. coli. Lies M, et al. Front Microbiol, 2015. PMID 26074904, Free PMC Article
  2. Nucleotide sequence of the origin of replication of the Escherichia coli K-12 chromosome. Meijer M, et al. Proc Natl Acad Sci U S A, 1979 Feb. PMID 370833, Free PMC Article
  3. Solution structures and backbone dynamics of a flavodoxin MioC from Escherichia coli in both Apo- and Holo-forms: implications for cofactor binding and electron transfer. Hu Y, et al. J Biol Chem, 2006 Nov 17. PMID 16963438
  4. Different effects of mioC transcription on initiation of chromosomal and minichromosomal replication in Escherichia coli. Løbner-Olesen A, et al. Nucleic Acids Res, 1992 Jun 25. PMID 1620598, Free PMC Article
  5. Stability and replication control of Escherichia coli minichromosomes. Løbner-Olesen A, et al. J Bacteriol, 1987 Jun. PMID 3294807, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: MioC is an FMN-binding protein that is essential for Escherichia coli biotin synthase activity in vitro.
  2. The solution structures of both the apo- and holo-forms of E. coli MioC protein at high resolution by nuclear magnetic resonance spectroscopy are reported.
    Title: Solution structures and backbone dynamics of a flavodoxin MioC from Escherichia coli in both Apo- and Holo-forms: implications for cofactor binding and electron transfer.
  3. A new set of rules for identifying efficiently titrating DnaA box regions was formulated and used to analyse sequences in mioC promoter.
    Title: Sequence characteristics required for cooperative binding and efficient in vivo titration of the replication initiator protein DnaA in E. coli.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables FMN binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables FMN binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
flavoprotein MioC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3926012..3926455 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418198.1 flavoprotein MioC [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418198.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A3L9FZL4
    Conserved Domains (1) summary
    PRK09004
    Location:1 → 146
    PRK09004; FMN-binding protein MioC; Provisional
Nucleotide Protein
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