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atpC ATP synthase F1 complex subunit epsilon [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948245, updated on 19-Sep-2024

Summary

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Official Symbol
atpC
Official Full Name
ATP synthase F1 complex subunit epsilon
Primary source
ECOCYC:EG10100
Locus tag
b3731
See related
ASAP:ABE-0012206
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3724; papG; uncC
Summary
The epsilon subunit appears to play an important role in coupling the catalytic site events with proton translocation in association with the gamma subunit. [More information is available at EcoCyc: EG10100].
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Genomic context

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Sequence:
NC_000913.3 (3915553..3915972, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene L-glutamine--D-fructose-6-phosphate aminotransferase Neighboring gene fused N-acetylglucosamine-1-phosphate uridyltransferase and glucosamine-1-phosphate acetyltransferase Neighboring gene ATP synthase F1 complex subunit beta Neighboring gene ATP synthase F1 complex subunit gamma

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mechanism of inhibition by C-terminal alpha-helices of the epsilon subunit of Escherichia coli FoF1-ATP synthase. Iino R, et al. J Biol Chem, 2009 Jun 26. PMID 19411254, Free PMC Article
  2. The role of the epsilon subunit in the Escherichia coli ATP synthase. The C-terminal domain is required for efficient energy coupling. Cipriano DJ, et al. J Biol Chem, 2006 Jan 6. PMID 16267041
  3. What is the role of epsilon in the Escherichia coli ATP synthase? Vik SB. J Bioenerg Biomembr, 2000 Oct. PMID 15254383
  4. Effect of the epsilon-subunit on nucleotide binding to Escherichia coli F1-ATPase catalytic sites. Weber J, et al. J Biol Chem, 1999 Jul 2. PMID 10383416
  5. Solution structure of the epsilon subunit of the F1-ATPase from Escherichia coli and interactions of this subunit with beta subunits in the complex. Wilkens S, et al. J Biol Chem, 1998 Oct 9. PMID 9756905

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A high-throughput genetically directed protein crosslinking analysis reveals the physiological relevance of the ATP synthase 'inserted' state.
    Title: A high-throughput genetically directed protein crosslinking analysis reveals the physiological relevance of the ATP synthase 'inserted' state.
  2. The studies on PapG-mediated interaction with cell surface-exposed glycosphingolipids will improve our knowledge on the molecular mechanisms of P-fimbriae-mediated adhesion and may contribute to the development of antiadhesion therapeutics to combat urinary tract infections.
    Title: PapG subtype-specific binding characteristics of Escherichia coli towards globo-series glycosphingolipids of human kidney and bladder uroepithelial cells.
  3. Unlike the bovine F1 ATP synthase, an E. coli enzyme contains an epsilon subunit, which is a known inhibitor of bacterial and chloroplast F1 ATPases. (Review)
    Title: ATP synthase from Escherichia coli: Mechanism of rotational catalysis, and inhibition with the ε subunit and phytopolyphenols.
  4. The epsilon-CTD of F1-ATPase has distinct regulatory interactions with F1 when rotary catalysis operates in opposite directions for the hydrolysis or synthesis of ATP.
    Title: Aerobic Growth of Escherichia coli Is Reduced, and ATP Synthesis Is Selectively Inhibited when Five C-terminal Residues Are Deleted from the ϵ Subunit of ATP Synthase.
  5. There is a significant predominance of allele papGII above all other alleles or allele combinations. No statistically significant associations could be found between papG allele distribution and the animal breed, organ of isolation and serotype.
    Title: Predominance of the PapGII allele among avian pathogenic Escherichia coli (APEC) with high sequence homology to human isolates.
  6. Vaginal and fecal E.coli isolates from pregnant and nonpregnant women were surveyed for papG alleles by PCR. papG allele II was most prevalent among both vaginal (32.7%) and fecal (3.2%) isolates; other alleles were found only among vaginal isolates.
    Title: Vaginal colonization by papG allele II+ Escherichia coli isolates from pregnant and nonpregnant women as predisposing factor to pyelonephritis.
  7. Destabilizing the compact conformation of epsilon's C-terminal domain with a phosphomimetic mutation (epsilonS65D) dramatically increased crystallization success and reproducibility, yielding crystals of E. coli F(1) that diffract to approximately 3.15 A resolution
    Title: Improved crystallization of Escherichia coli ATP synthase catalytic complex (F1) by introducing a phosphomimetic mutation in subunit ε.
  8. depending on its conformation, epsilon-subunit modulates substrate specificity of TF(o)F(1)
    Title: Modulation of nucleotide specificity of thermophilic F(o)F(1)-ATP Synthase by epsilon-subunit.
  9. Mutants defective in C-terminal regulatory domain exhibited no significant difference in growth rate, molar growth yield, membrane potential, or intracellular ATP concentration under a wide range of growth conditions and stressors.
    Title: The regulatory C-terminal domain of subunit ε of F₀F₁ ATP synthase is dispensable for growth and survival of Escherichia coli.
  10. analysis of epsilon and gamma subunits roles in inhibited and active states of Escherichia coli ATP synthase F1 rotation
    Title: Single molecule behavior of inhibited and active states of Escherichia coli ATP synthase F1 rotation.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to proton-transporting ATP synthase activity, rotational mechanism IDA
Inferred from Direct Assay
more info
 PubMed 
enables proton-transporting ATP synthase activity, rotational mechanism IDA
Inferred from Direct Assay
more info
 PubMed 
enables proton-transporting ATP synthase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ATP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proton motive force-driven ATP synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proton motive force-driven ATP synthesis IEA
Inferred from Electronic Annotation
more info
  
involved_in proton motive force-driven plasma membrane ATP synthesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of proton-transporting ATP synthase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of proton-transporting ATP synthase complex, catalytic core F(1) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proton-transporting ATP synthase complex, catalytic core F(1) IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proton-transporting ATP synthase complex, catalytic core F(1) IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ATP synthase F1 complex subunit epsilon
NP_418187.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3915553..3915972 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418187.1 ATP synthase F1 complex subunit epsilon [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418187.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8T3UCB4
    Conserved Domains (1) summary
    PRK00571
    Location:2 → 136
    atpC; F0F1 ATP synthase subunit epsilon; Validated
Nucleotide Protein
Heading Accession and Version

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