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ilvB acetohydroxy acid synthase I subunit IlvB [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948182, updated on 19-Sep-2024

Summary

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Official Symbol
ilvB
Official Full Name
acetohydroxy acid synthase I subunit IlvB
Primary source
ECOCYC:EG10494
Locus tag
b3671
See related
ASAP:ABE-0011999
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3662
Summary
Bifunctional acetohydroxybutanoate synthase / acetolactate synthase (IlvB/N) carries out both the first step in valine biosynthesis and the second step in isoleucine biosynthesis. [More information is available at EcoCyc: EG10494].
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Genomic context

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Sequence:
NC_000913.3 (3851096..3852784, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene sensory histidine kinase UhpB Neighboring gene DNA-binding transcriptional activator UhpA Neighboring gene acetohydroxy acid synthase I subunit IlvN Neighboring gene ilvBN operon leader peptide Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Plasmid-associated functions of a stable Flac. Macrina FL, et al. J Bacteriol, 1973 Jan. PMID 4569402, Free PMC Article
  2. Nucleotide sequence of the ilvB multivalent attenuator region of Escherichia coli K12. Hauser CA, et al. Nucleic Acids Res, 1983 Jan 11. PMID 6346263, Free PMC Article
  3. Escherichia coli ilvN interacts with the FAD binding domain of ilvB and activates the AHAS I enzyme. Mitra A, et al. Biochemistry, 2008 Feb 12. PMID 18193896
  4. Acetohydroxy acid synthase I of Escherichia coli: purification and properties. Grimminger H, et al. J Bacteriol, 1979 Feb. PMID 370104, Free PMC Article
  5. Role of small subunit (IlvN polypeptide) of acetohydroxyacid synthase I from Escherichia coli K-12 in sensitivity of the enzyme to valine inhibition. Eoyang L, et al. J Bacteriol, 1986 Jun. PMID 3011751, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables acetolactate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetolactate synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acetolactate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables thiamine pyrophosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-valine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within L-valine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in L-valine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in branched-chain amino acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in branched-chain amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in isoleucine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within isoleucine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in isoleucine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of acetolactate synthase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of acetolactate synthase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of acetolactate synthase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
acetohydroxy acid synthase I subunit IlvB
NP_418127.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3851096..3852784 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418127.1 acetohydroxy acid synthase I subunit IlvB [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418127.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376FV27, A0A828NVH1, A0A8S7F8F1, A0A8S7TK91
    Conserved Domains (1) summary
    PRK08155
    Location:1 → 562
    PRK08155; acetolactate synthase large subunit
Nucleotide Protein
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