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rfaD ADP-L-glycero-D-mannoheptose 6-epimerase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948134, updated on 10-Oct-2024

Summary

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Official Symbol
rfaD
Official Full Name
ADP-L-glycero-D-mannoheptose 6-epimerase
Primary source
ECOCYC:EG10838
Locus tag
b3619
See related
ASAP:ABE-0011843
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3609; hldD; htrM; nbsB; waaD
Summary
The hldD gene encodes ADP-L-glycero-D-mannoheptose-6-epimerase, the last enzyme in the pathway for synthesis of the ADP-heptose precursor of core LPS . [More information is available at EcoCyc: EG10838].
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Genomic context

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Sequence:
NC_000913.3 (3793987..3794919)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 2-amino-3-ketobutyrate CoA ligase Neighboring gene protein HtrL Neighboring gene ADP-heptose--LPS heptosyltransferase 2 Neighboring gene ADP-heptose:LPS heptosyltransferase 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Intermediate release by ADP-L-glycero-D-manno-heptose 6-epimerase. Mayer A, et al. Biochemistry, 2007 May 22. PMID 17455913
  2. A two-base mechanism for Escherichia coli ADP-L-glycero-D-manno-heptose 6-epimerase. Morrison JP, et al. Biochemistry, 2007 Mar 27. PMID 17316025
  3. The htrM gene, whose product is essential for Escherichia coli viability only at elevated temperatures, is identical to the rfaD gene. Raina S, et al. Nucleic Acids Res, 1991 Jul 25. PMID 1861974, Free PMC Article
  4. The rfaD gene codes for ADP-L-glycero-D-mannoheptose-6-epimerase. An enzyme required for lipopolysaccharide core biosynthesis. Coleman WG Jr. J Biol Chem, 1983 Feb 10. PMID 6337148
  5. Dismutase activity of ADP-L-glycero-D-manno-heptose 6-epimerase: evidence for a direct oxidation/reduction mechanism. Morrison JP, et al. Biochemistry, 2005 Apr 19. PMID 15823050

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Among the nine mutants resistant to coliphage infection that authors selected, six were in the fhuA gene, two were mutated in the waaC gene, and one was mutated in the gmhD gene.
    Title: A novel strategy to isolate cell-envelope mutants resistant to phage infection: bacteriophage mEp213 requires lipopolysaccharides in addition to FhuA to enter Escherichia coli K-12.
  2. N-terminus verified by Edman degradation on complete protein
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
  3. the epimerase employs a transient oxidation strategy involving a tightly bound NADP(+) cofactor
    Title: Dismutase activity of ADP-L-glycero-D-manno-heptose 6-epimerase: evidence for a direct oxidation/reduction mechanism.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

General protein information

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Preferred Names
ADP-L-glycero-D-mannoheptose 6-epimerase
NP_418076.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3793987..3794919
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418076.1 ADP-L-glycero-D-mannoheptose 6-epimerase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418076.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AAN4JKT4, A0AAN5KG23
    Conserved Domains (1) summary
    PRK11150
    Location:1 → 308
    rfaD; ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional
Nucleotide Protein
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