CD36 CD36 molecule (CD36 blood group) [Homo sapiens (human)] - Gene

Summary

Official Symbol: CD36provided by HGNC
Official Full Name: CD36 molecule (CD36 blood group)provided by HGNC
Primary source: HGNC:HGNC:1663
See related: Ensembl:ENSG00000135218 MIM:173510; AllianceGenome:HGNC:1663
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FAT; GP4; GP3B; GPIV; CHDS7; PASIV; SCARB3; BDPLT10
Summary: The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014]
Expression: Biased expression in fat (RPKM 547.7), heart (RPKM 79.1) and 4 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7q21.11

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (80602207..80679274)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (81853488..81930588)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (80231523..80308590)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A novel peptide encoded by circ-SLC9A6 promotes lipid dyshomeostasis through the regulation of H4K16ac-mediated CD36 transcription in NAFLD.
Title: A novel peptide encoded by circ-SLC9A6 promotes lipid dyshomeostasis through the regulation of H4K16ac-mediated CD36 transcription in NAFLD.
miR-1268a Regulates Fatty Acid Metabolism by Targeting CD36 in Angiotensin II-induced Heart Failure.
Title: miR-1268a Regulates Fatty Acid Metabolism by Targeting CD36 in Angiotensin II-induced Heart Failure.
Cancer-associated fibroblasts contributed to hepatocellular carcinoma recurrence and metastasis via CD36-mediated fatty-acid metabolic reprogramming.
Title: Cancer-associated fibroblasts contributed to hepatocellular carcinoma recurrence and metastasis via CD36-mediated fatty-acid metabolic reprogramming.
Genotypic and Allelic Distribution of the CD36 rs1761667 Polymorphism in High-Level Moroccan Athletes: A Pilot Study.
Title: Genotypic and Allelic Distribution of the CD36 rs1761667 Polymorphism in High-Level Moroccan Athletes: A Pilot Study.
The cluster of differentiation 36 (CD36) rs1761667 polymorphism interacts with dietary patterns to affect cardiometabolic risk factors and metabolic syndrome risk in apparently healthy individuals.
Title: The cluster of differentiation 36 (CD36) rs1761667 polymorphism interacts with dietary patterns to affect cardiometabolic risk factors and metabolic syndrome risk in apparently healthy individuals.
Genetic Variants in CD36 Involved in Fat Taste Perception: Association with Anthropometric and Clinical Parameters in Overweight and Obese Subjects Affected by Type 2 Diabetes or Dysglycemia-A Pilot Study.
Title: Genetic Variants in CD36 Involved in Fat Taste Perception: Association with Anthropometric and Clinical Parameters in Overweight and Obese Subjects Affected by Type 2 Diabetes or Dysglycemia-A Pilot Study.
SELENOK-dependent CD36 palmitoylation regulates microglial functions and Abeta phagocytosis.
Title: SELENOK-dependent CD36 palmitoylation regulates microglial functions and Aβ phagocytosis.
CD36 polymorphism, sugary drinks, and sedentarism are associated with hypertriglyceridemic waist phenotype.
Title: CD36 polymorphism, sugary drinks, and sedentarism are associated with hypertriglyceridemic waist phenotype.
The activated CD36-Src axis promotes lung adenocarcinoma cell proliferation and actin remodeling-involved metastasis in high-fat environment.
Title: The activated CD36-Src axis promotes lung adenocarcinoma cell proliferation and actin remodeling-involved metastasis in high-fat environment.
TM6SF2 reduces lipid accumulation in vascular smooth muscle cells by inhibiting LOX-1 and CD36 expression.
Title: TM6SF2 reduces lipid accumulation in vascular smooth muscle cells by inhibiting LOX-1 and CD36 expression.

Submit: New GeneRIF Correction See all GeneRIFs (448)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Coronary heart disease, susceptibility to, 7 MedGen: C1970441 OMIM: 610938 GeneReviews: Not available	not available
Malaria, susceptibility to MedGen: C1970028 OMIM: 611162 GeneReviews: Not available	not available
Platelet-type bleeding disorder 10 MedGen: C1842090 OMIM: 608404 GeneReviews: Not available	not available

EBI GWAS Catalog

Description
A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies single-nucleotide polymorphism in KCNB1 associated with left ventricular mass in humans: the HyperGEN Study. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study indicates variants associated with insulin signaling and inflammation mediate lipoprotein responses to fenofibrate. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp160, precursor	env	CD36 co-localizes with HIV-1 Env in the cellular virus-containing compartments of macrophages	PubMed
Envelope transmembrane glycoprotein gp41	env	A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of CD36 molecule (CD36; thrombospondin receptor) in peptide-treated PBMCs	PubMed
Nef	nef	HIV-1 myristoylated Nef-induced TNF-alpha release leads to downregulation of CD36 expression by myristoylated Nef in monocyte-derived macrophages	PubMed
	nef	HIV-1 myristoylated Nef downregulates CD36 expression in monocytes from PBMCs and monocyte-derived macrophages differentiated by cytokines. Nef-dependent downregulation of CD36 involves mRNA transcriptional inhibition	PubMed
Pr55(Gag)	gag	CD36 co-localizes with HIV-1 Gag in the cellular virus-containing compartments and is required for efficient HIV-1 release by primary macrophages	PubMed
capsid	gag	CD36 induces release of p24 in primary macrophages. Knockdown of CD36 by siRNA restricts the activity of CD36	PubMed
matrix	gag	Treatment of human PBMCs with HIV-1 MA upregulates the expression of MCP-1, ICAM-1, CD40, CD86 and CD36 and downregulates the expression of nuclear receptors FXR and PPARgamma	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH93476 (e-PCR)
- UniSTS:89093

GDB:212872 (e-PCR)
- UniSTS:156177

CD36 (e-PCR)
- UniSTS:42011

WI-16804 (e-PCR)
- UniSTS:60190

D7S2791 (e-PCR)
- UniSTS:64036

sY3084 (e-PCR)
- UniSTS:515126

RH36282 (e-PCR)
- UniSTS:71991

G62603 (e-PCR)
- UniSTS:139583

D7S2067E (e-PCR)
- UniSTS:151120

ha3206 (e-PCR)
- UniSTS:515665

SHGC-106381 (e-PCR)
- UniSTS:169823

RH48982 (e-PCR)
- UniSTS:46184

D1S1423 (e-PCR)
- UniSTS:149619

RH69590 (e-PCR)
- UniSTS:68241

RH94289 (e-PCR)
- UniSTS:85145

STS-W90039 (e-PCR)
- UniSTS:64671

RH70387 (e-PCR)
- UniSTS:89003

D7S2891 (e-PCR)
- UniSTS:38344

SHGC-58145 (e-PCR)
- UniSTS:65994

RH104443 (e-PCR)
- UniSTS:98768

GDB:3755118 (e-PCR)
- UniSTS:52446

STS-T89178 (e-PCR)
- UniSTS:37858

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables Toll-like receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables amyloid-beta binding	IC Inferred by Curator more info	PubMed
enables amyloid-beta binding	IDA Inferred from Direct Assay more info	PubMed
enables amyloid-beta binding	TAS Traceable Author Statement more info	PubMed
enables cargo receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables high-density lipoprotein particle binding	IEA Inferred from Electronic Annotation more info
enables lipid binding	IDA Inferred from Direct Assay more info	PubMed
enables lipoprotein particle binding	IDA Inferred from Direct Assay more info	PubMed
enables lipoteichoic acid immune receptor activity	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acid transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables long-chain fatty acid transmembrane transporter activity	TAS Traceable Author Statement more info
enables low-density lipoprotein particle binding	IBA Inferred from Biological aspect of Ancestor more info
enables low-density lipoprotein particle binding	IDA Inferred from Direct Assay more info	PubMed
enables low-density lipoprotein particle receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables low-density lipoprotein particle receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables low-density lipoprotein particle receptor activity	TAS Traceable Author Statement more info	PubMed
enables oleate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables oxidised low-density lipoprotein particle receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables scavenger receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables scavenger receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables scavenger receptor activity	TAS Traceable Author Statement more info	PubMed
enables short-chain fatty acid transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables thrombospondin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables thrombospondin receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables transforming growth factor beta binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in amyloid fibril formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in amyloid-beta clearance by cellular catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in amyloid-beta clearance by cellular catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic cell clearance	IEA Inferred from Electronic Annotation more info
involved_in blood coagulation	TAS Traceable Author Statement more info	PubMed
involved_in cGMP-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amyloid-beta	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to diacyl bacterial lipopeptide	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to diacyl bacterial lipopeptide	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to hydroperoxide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipoteichoic acid	IEA Inferred from Electronic Annotation more info
involved_in cellular response to low-density lipoprotein particle stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to oxidised low-density lipoprotein particle stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cholesterol import	ISS Inferred from Sequence or Structural Similarity more info
involved_in cholesterol transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in defense response to Gram-positive bacterium	IEA Inferred from Electronic Annotation more info
involved_in energy homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in fatty acid metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in fatty acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in intestinal absorption	ISS Inferred from Sequence or Structural Similarity more info
involved_in intestinal cholesterol absorption	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid metabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in lipid storage	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid transport across blood-brain barrier	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipoprotein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipoprotein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipoprotein transport	TAS Traceable Author Statement more info	PubMed
involved_in long-chain fatty acid import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in long-chain fatty acid import into cell	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-chain fatty acid import into cell	IDA Inferred from Direct Assay more info	PubMed
involved_in long-chain fatty acid transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in low-density lipoprotein particle clearance	IBA Inferred from Biological aspect of Ancestor more info
involved_in low-density lipoprotein particle clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in low-density lipoprotein particle mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in nitric oxide-cGMP-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in oxidised low-density lipoprotein particle clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagocytosis, engulfment	TAS Traceable Author Statement more info	PubMed
involved_in phagocytosis, recognition	IEA Inferred from Electronic Annotation more info
involved_in plasma lipoprotein particle clearance	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of NLRP3 inflammasome complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of blood coagulation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of blood microparticle formation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell-matrix adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cholesterol storage	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-1 beta production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-12 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of macrophage cytokine production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of macrophage derived foam cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nitric oxide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phagocytosis, engulfment	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of reactive oxygen species biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of tumor necrosis factor production	IEA Inferred from Electronic Annotation more info
involved_in production of molecular mediator involved in inflammatory response	TAS Traceable Author Statement more info	PubMed
involved_in receptor internalization	ISS Inferred from Sequence or Structural Similarity more info
involved_in receptor-mediated endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor-mediated endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of action potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of lipopolysaccharide-mediated signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in regulation of protein-containing complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of removal of superoxide radicals	IEA Inferred from Electronic Annotation more info
involved_in regulation of toll-like receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to fatty acid	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to linoleic acid	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to lipid	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to stilbenoid	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of taste	ISS Inferred from Sequence or Structural Similarity more info
involved_in short-chain fatty acid transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in triglyceride transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in brush border membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in caveola	IBA Inferred from Biological aspect of Ancestor more info
located_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
located_in cell surface	TAS Traceable Author Statement more info	PubMed
located_in endocytic vesicle membrane	TAS Traceable Author Statement more info
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular space	HDA more info	PubMed
located_in membrane	TAS Traceable Author Statement more info	PubMed
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in phagocytic vesicle	TAS Traceable Author Statement more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
located_in platelet alpha granule membrane	TAS Traceable Author Statement more info
part_of receptor complex	IPI Inferred from Physical Interaction more info	PubMed
located_in specific granule membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: platelet glycoprotein 4

Names: CD36 antigen (collagen type I receptor, thrombospondin receptor); CD36 molecule (thrombospondin receptor); GPIIIB; PAS IV; PAS-4 protein; cluster determinant 36; fatty acid translocase; glycoprotein IIIb; leukocyte differentiation antigen CD36; platelet glycoprotein IV; scavenger receptor class B, member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_008192.1 RefSeqGene

Range

41455..82087

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000072.3 → NP_000063.2 platelet glycoprotein 4 isoform 1

See identical proteins and their annotated locations for NP_000063.2

Status: REVIEWED

Description

Transcript Variant: This variant (3) encodes the longest isoform (1). Variants 1-5 and 10-13 all encode the same isoform (1).

Source sequence(s)

AC124834, DA857400, DC338512, L06850, M98398

Consensus CDS

CCDS34673.1

UniProtKB/Swiss-Prot

D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5

UniProtKB/TrEMBL

A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65

Related

ENSP00000378268.3, ENST00000394788.7

Conserved Domains (1) summary

pfam01130
Location:14 → 463

CD36; CD36 family
NM_001001547.3 → NP_001001547.1 platelet glycoprotein 4 isoform 1

See identical proteins and their annotated locations for NP_001001547.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) has an alternate 5' UTR exon, compared to variant 3. Variants 1-5 and 10-13 all encode the same isoform (1).

Source sequence(s)

BP258762, BP259746, L06850, M98398

Consensus CDS

CCDS34673.1

UniProtKB/Swiss-Prot

D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5

UniProtKB/TrEMBL

A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65

Related

ENSP00000308165.7, ENST00000309881.11

Conserved Domains (1) summary

pfam01130
Location:14 → 463

CD36; CD36 family
NM_001001548.3 → NP_001001548.1 platelet glycoprotein 4 isoform 1

See identical proteins and their annotated locations for NP_001001548.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) has an alternate 3' UTR, compared to variant 3. Variants 1-5 and 10-13 all encode the same isoform (1).

Source sequence(s)

AC073850, AC124834

Consensus CDS

CCDS34673.1

UniProtKB/Swiss-Prot

D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5

UniProtKB/TrEMBL

A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65

Related

ENSP00000415743.2, ENST00000447544.7

Conserved Domains (1) summary

pfam01130
Location:14 → 463

CD36; CD36 family
NM_001127443.2 → NP_001120915.1 platelet glycoprotein 4 isoform 1

See identical proteins and their annotated locations for NP_001120915.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 3. Variants 1-5 and 10-13 all encode the same isoform (1).

Source sequence(s)

AC073850, DA566475, L06850, M98398

Consensus CDS

CCDS34673.1

UniProtKB/Swiss-Prot

D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5

UniProtKB/TrEMBL

A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65

Related

ENSP00000411411.1, ENST00000432207.5

Conserved Domains (1) summary

pfam01130
Location:14 → 463

CD36; CD36 family
NM_001127444.2 → NP_001120916.1 platelet glycoprotein 4 isoform 1

See identical proteins and their annotated locations for NP_001120916.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 3. Variants 1-5 and 10-13 all encode the same isoform (1).

Source sequence(s)

AL596924, L06850, M98398

Consensus CDS

CCDS34673.1

UniProtKB/Swiss-Prot

D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5

UniProtKB/TrEMBL

A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65

Related

ENSP00000392298.2, ENST00000419819.2

Conserved Domains (1) summary

pfam01130
Location:14 → 463

CD36; CD36 family
NM_001289908.1 → NP_001276837.1 platelet glycoprotein 4 isoform 2

See identical proteins and their annotated locations for NP_001276837.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks two consecutive exons in the 3' coding region, compared to variant 3. The resulting isoform (2) lacks an internal segment, compared to isoform 1.

Source sequence(s)

AK300101, HM217026, L06850

Consensus CDS

CCDS78249.1

UniProtKB/TrEMBL

B3KUB8, D9IX63, D9IX64, D9IX65

Related

ENSP00000401863.2, ENST00000433696.6

Conserved Domains (1) summary

pfam01130
Location:16 → 422

CD36; CD36 family
NM_001289909.1 → NP_001276838.1 platelet glycoprotein 4 isoform 3

See identical proteins and their annotated locations for NP_001276838.1

Status: REVIEWED

Description

Transcript Variant: This variant (7) lacks an in-frame coding exon, compared to variant 3. The resulting isoform (3) lacks an internal segment, compared to isoform 1.

Source sequence(s)

AK300101, BC008406, HM217023, L06850

Consensus CDS

CCDS78250.1

UniProtKB/TrEMBL

B3KUB8, D9IX65

Related

ENSP00000439543.1, ENST00000538969.5

Conserved Domains (1) summary

pfam01130
Location:16 → 401

CD36; CD36 family
NM_001289911.2 → NP_001276840.1 platelet glycoprotein 4 isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (8) contains an alternate 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate downstream AUG, compared to variant 3. The resulting isoform (4) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AK300101, AK312920, L06850

Consensus CDS

CCDS78251.1

UniProtKB/TrEMBL

B7Z6C3, E9PLT1

Related

ENSP00000431296.1, ENST00000534394.5

Conserved Domains (1) summary

pfam01130
Location:1 → 385

CD36; CD36 family
NM_001371074.1 → NP_001358003.1 platelet glycoprotein 4 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (10), as well as variants 1-5 and 11-13, encodes isoform 1.

Source sequence(s)

AC073182, AC073850

Consensus CDS

CCDS34673.1

UniProtKB/Swiss-Prot

D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5

UniProtKB/TrEMBL

A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65

Conserved Domains (1) summary

pfam01130
Location:14 → 463

CD36; CD36 family
NM_001371075.1 → NP_001358004.1 platelet glycoprotein 4 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (11), as well as variants 1-5, 10, 12, and 13, encodes isoform 1.

Source sequence(s)

AC073182, AC073850

Consensus CDS

CCDS34673.1

UniProtKB/Swiss-Prot

D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5

UniProtKB/TrEMBL

A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65

Conserved Domains (1) summary

pfam01130
Location:14 → 463

CD36; CD36 family
NM_001371077.1 → NP_001358006.1 platelet glycoprotein 4 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (12), as well as variants 1-5, 10, 11, and 13, encodes isoform 1.

Source sequence(s)

AC073850, AC124834

Consensus CDS

CCDS34673.1

UniProtKB/Swiss-Prot

D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5

UniProtKB/TrEMBL

A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65

Conserved Domains (1) summary

pfam01130
Location:14 → 463

CD36; CD36 family
NM_001371078.1 → NP_001358007.1 platelet glycoprotein 4 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (13), as well as variants 1-5 and 10-12, encodes isoform 1.

Source sequence(s)

AC073850, AC124834

Consensus CDS

CCDS34673.1

UniProtKB/Swiss-Prot

D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5

UniProtKB/TrEMBL

A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65

Related

ENSP00000399421.1, ENST00000435819.5

Conserved Domains (1) summary

pfam01130
Location:14 → 463

CD36; CD36 family
NM_001371079.1 → NP_001358008.1 platelet glycoprotein 4 isoform 5

Status: REVIEWED

Source sequence(s)

AC073850, AC124834

UniProtKB/TrEMBL

D9IX64

Conserved Domains (1) summary

pfam01130
Location:16 → 429

CD36; CD36 family
NM_001371080.1 → NP_001358009.1 platelet glycoprotein 4 isoform 6

Status: REVIEWED

Description

Transcript Variant: This variant (15), as well as variant 16, encodes isoform 6.

Source sequence(s)

AC073182, AC073850

UniProtKB/TrEMBL

B7Z6C3

Conserved Domains (1) summary

pfam01130
Location:1 → 308

CD36; CD36 family
NM_001371081.1 → NP_001358010.1 platelet glycoprotein 4 isoform 6

Status: REVIEWED

Description

Transcript Variant: This variant (16), as well as variant 15, encodes isoform 6.

Source sequence(s)

AC073182, AC073850

UniProtKB/TrEMBL

B7Z6C3

Conserved Domains (1) summary

pfam01130
Location:1 → 308

CD36; CD36 family

RNA

NR_110501.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (9) lacks an internal exon in the 3' region, compared to variant 3. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK300101, BC008406, HM217025, L06850

Related

ENST00000544133.5