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nikB Ni(2(+)) ABC transporter membrane subunit NikB [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947986, updated on 19-Sep-2024

Summary

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Official Symbol
nikB
Official Full Name
Ni(2(+)) ABC transporter membrane subunit NikB
Primary source
ECOCYC:EG12076
Locus tag
b3477
See related
ASAP:ABE-0011356
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3461; hydC; hydD
Summary
Mutants display nickel-remediated formate hydrogen-lyase, hydrogenase, and hydrogenase-related fumarase defects. [More information is available at EcoGene: EG12076]. The NikABCDE ATP-dependent nickel (II) uptake system is a member of the ATP-Binding Cassette (ABC) Superfamily of transporters . [More information is available at EcoCyc: EG12076].
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Genomic context

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Sequence:
NC_000913.3 (3615241..3616185)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene holo-[acyl carrier protein] synthase 2 Neighboring gene Ni(2(+)) ABC transporter periplasmic binding protein Neighboring gene Ni(2(+)) ABC transporter membrane subunit NikC Neighboring gene Ni(2(+)) ABC transporter ATP binding subunit NikD Neighboring gene Ni(2(+)) ABC transporter ATP binding subunit NikE Neighboring gene DNA-binding transcriptional repressor NikR

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The hydC region contains a multi-cistronic operon (nik) involved in nickel transport in Escherichia coli. Wu LF, et al. Gene, 1991 Oct 30. PMID 1743519
  2. Purification and characterization of the periplasmic nickel-binding protein NikA of Escherichia coli K12. de Pina K, et al. Eur J Biochem, 1995 Feb 1. PMID 7867647
  3. Identification of Ni-(L-His)₂ as a substrate for NikABCDE-dependent nickel uptake in Escherichia coli. Chivers PT, et al. Metallomics, 2012 Oct. PMID 22885853
  4. Crystallographic and spectroscopic evidence for high affinity binding of FeEDTA(H2O)- to the periplasmic nickel transporter NikA. Cherrier MV, et al. J Am Chem Soc, 2005 Jul 20. PMID 16011372
  5. Nickel transport systems in microorganisms. Eitinger T, et al. Arch Microbiol, 2000 Jan. PMID 10648098

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables dipeptide transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nickel cation binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nickel cation transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables nickel cation transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in dipeptide transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nickel cation import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nickel cation import across plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in nickel cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nickel cation transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
Ni(2(+)) ABC transporter membrane subunit NikB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3615241..3616185
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417934.1 Ni(2(+)) ABC transporter membrane subunit NikB [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417934.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376M2K8
    Conserved Domains (1) summary
    PRK10352
    Location:1 → 314
    PRK10352; nickel transporter permease NikB; Provisional
Nucleotide Protein
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