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malP maltodextrin phosphorylase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947922, updated on 19-Sep-2024

Summary

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Official Symbol
malP
Official Full Name
maltodextrin phosphorylase
Primary source
ECOCYC:EG10560
Locus tag
b3417
See related
ASAP:ABE-0011154
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
blu; ECK3404; malA
Summary
MalT regulon. [More information is available at EcoGene: EG10560]. The malP gene product, maltodextrin phosphorylase, is one of two distinct -glucan phosphorylases in Escherichia coli. [More information is available at EcoCyc: EG10560].
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Genomic context

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Sequence:
NC_000913.3 (3550080..3552473, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene high-affinity gluconate transporter Neighboring gene 4-alpha-glucanotransferase Neighboring gene DNA-binding transcriptional activator MalT Neighboring gene RNA 3'-terminal phosphate cyclase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The crystal structure of Escherichia coli maltodextrin phosphorylase provides an explanation for the activity without control in this basic archetype of a phosphorylase. Watson KA, et al. EMBO J, 1997 Jan 2. PMID 9009262, Free PMC Article
  2. pH dependence of the kinetic parameters of maltodextrin phosphorylase. Chao J, et al. Biochem Biophys Res Commun, 1970 Sep 30. PMID 4933689
  3. The role of pyridoxal 5'-phosphate in glycogen phosphorylase catalysis. Palm D, et al. Biochemistry, 1990 Feb 6. PMID 2182117
  4. Kinetic mechanism of maltodextrin phosphorylase. Chao J, et al. Biochemistry, 1969 Apr. PMID 4897523
  5. Escherichia coli maltodextrin phosphorylase: contribution of active site residues glutamate-637 and tyrosine-538 to the phosphorolytic cleavage of alpha-glucans. Schinzel R, et al. Biochemistry, 1990 Oct 23. PMID 1980213

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The action of MalQ on maltose or maltodextrin can lead to the formation of glycogen and that MalP controls (inhibits) this pathway.
    Title: Role of maltose enzymes in glycogen synthesis by Escherichia coli.
  2. Difficulty is reported in determining MalP ternary complexes from the crystal structures having in the catalytic site both substrates, oligosaccharide and tetrahedral phosphate analogues, at full occupancy and with low thermal factors.
    Title: X-ray studies on ternary complexes of maltodextrin phosphorylase.
  3. N-terminus verified by Edman degradation on mature peptide
    Title: N-terminal sequences of Escherichia coli and potato phosphorylase.
  4. A comparison of ATPHS2 and DPE2 from A. thaliana with MalP and MalQ from E. coli is presented.
    Title: The role of cytosolic alpha-glucan phosphorylase in maltose metabolism and the comparison of amylomaltase in Arabidopsis and Escherichia coli.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 1,4-alpha-oligoglucan phosphorylase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycogen phosphorylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycogen phosphorylase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables maltodextrin phosphorylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyridoxal phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyridoxal phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within alpha-glucan catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within alpha-glucan catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycogen catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within glycogen catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
maltodextrin phosphorylase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3550080..3552473 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_026218.1 maltodextrin phosphorylase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for YP_026218.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8T6A2X1
    Conserved Domains (1) summary
    PRK14985
    Location:2 → 797
    PRK14985; maltodextrin phosphorylase; Provisional
Nucleotide Protein
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