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malT DNA-binding transcriptional activator MalT [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947921, updated on 19-Sep-2024

Summary

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Official Symbol
malT
Official Full Name
DNA-binding transcriptional activator MalT
Primary source
ECOCYC:EG10562
Locus tag
b3418
See related
ASAP:ABE-0011162
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3405; malA
Summary
Activated by maltotriose and ATP to form active oligomers. [More information is available at EcoGene: EG10562]. The malT gene is located upstream of and in the opposite direction of the operon malPQ . [More information is available at EcoCyc: EG10562].
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Genomic context

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Sequence:
NC_000913.3 (3553085..3555790)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 4-alpha-glucanotransferase Neighboring gene maltodextrin phosphorylase Neighboring gene RNA 3'-terminal phosphate cyclase Neighboring gene RNA-splicing ligase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutants which make more malT product, the activator of the maltose regulon in Escherichia coli. Débarbouillé M, et al. Mol Gen Genet, 1980. PMID 6993855
  2. Crystal structure of transcription factor MalT domain III: a novel helix repeat fold implicated in regulated oligomerization. Steegborn C, et al. Structure, 2001 Nov. PMID 11709169
  3. A complex signaling module governs the activity of MalT, the prototype of an emerging transactivator family. Danot O. Proc Natl Acad Sci U S A, 2001 Jan 16. PMID 11209048, Free PMC Article
  4. Learning new tricks from an old dog: MalT of the Escherichia coli maltose system is part of a complex regulatory network. Boos W, et al. Trends Genet, 2000 Sep. PMID 10973069
  5. Self-association of the Escherichia coli transcription activator MalT in the presence of maltotriose and ATP. Schreiber V, et al. J Biol Chem, 1999 Nov 19. PMID 10559195

See all (75) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mutations upstream from sdaC and malT in Escherichia coli uncover a complex interplay between the cAMP receptor protein and different sigma factors.
    Title: Mutations upstream from sdaC and malT in Escherichia coli uncover a complex interplay between the cAMP receptor protein and different sigma factors.
  2. pinpointed the NOD-arm interface of the MalT STAND transcription factor, and generated a MalT variant in which this interface can be covalently locked on demand, thereby trapping the NOD in the closed state
    Title: How 'arm-twisting' by the inducer triggers activation of the MalT transcription factor, a typical signal transduction ATPase with numerous domains (STAND).
  3. The molecular entity that interacts with MalT is not free MalK, but the maltose transporter, MalFGK(2) , which sequesters MalT to the membrane.
    Title: The ABC transporter MalFGK(2) sequesters the MalT transcription factor at the membrane in the absence of cognate substrate.
  4. The inducer maltotriose binds in the central cavity of the tetratricopeptide-like sensor domain of MalT.
    Title: The inducer maltotriose binds in the central cavity of the tetratricopeptide-like sensor domain of MalT, a bacterial STAND transcription factor.
  5. Substitutions of R171 impaired both ATP hydrolysis and multimerization, which is consistent with an arginine finger function and provides further evidence that ATP hydrolysis is primarily catalyzed by MalT multimers.
    Title: Conserved motifs involved in ATP hydrolysis by MalT, a signal transduction ATPase with numerous domains from Escherichia coli.
  6. Data report that cells lacking OmpR and harboring constitutively active MalT undergo premature death that involves increased expression of the outer membrane porin LamB.
    Title: A critical process controlled by MalT and OmpR is revealed through synthetic lethality.
  7. Overexpression of glk leads to a reduction in mal gene expression and interpret of this repression is a direct interaction of Glk with MalT concomitant with MalT inhibition.
    Title: Glucose- and glucokinase-controlled mal gene expression in Escherichia coli.
  8. ATPase activity of malT is not essential for downstream signaling but plays a key role in the integration of regulatory signals.
    Title: How integration of positive and negative regulatory signals by a STAND signaling protein depends on ATP hydrolysis.
  9. Data suggest that the MalT/MalK interaction might involve two distinct contact sites on each partner.
    Title: Two domains of MalT, the activator of the Escherichia coli maltose regulon, bear determinants essential for anti-activation by MalK.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables trisaccharide binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA-binding transcriptional activator MalT

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3553085..3555790
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417877.1 DNA-binding transcriptional activator MalT [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417877.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7JLT0
    Conserved Domains (1) summary
    PRK04841
    Location:1 → 900
    PRK04841; HTH-type transcriptional regulator MalT
Nucleotide Protein
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