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degQ periplasmic serine endoprotease [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947812, updated on 19-Sep-2024

Summary

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Official Symbol
degQ
Official Full Name
periplasmic serine endoprotease
Primary source
ECOCYC:G7682
Locus tag
b3234
See related
ASAP:ABE-0010609
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3223; hhoA
Summary
DegQ is a serine endoprotease that may be involved in degrading transiently denatured proteins . [More information is available at EcoCyc: G7682].
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Genomic context

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Sequence:
NC_000913.3 (3380743..3382110)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene cell division protein ZapE Neighboring gene Z-ring associated protein G Neighboring gene serine endoprotease Neighboring gene malate dehydrogenase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ. Malet H, et al. Nat Struct Mol Biol, 2012 Jan 15. PMID 22245966, Free PMC Article
  2. Molecular adaptation of the DegQ protease to exert protein quality control in the bacterial cell envelope. Sawa J, et al. J Biol Chem, 2011 Sep 2. PMID 21685389, Free PMC Article
  3. pH-dependent catabolic protein expression during anaerobic growth of Escherichia coli K-12. Yohannes E, et al. J Bacteriol, 2004 Jan. PMID 14679238, Free PMC Article
  4. Roles of DegP in prevention of protein misfolding in the periplasm upon overexpression of penicillin acylase in Escherichia coli. Pan KL, et al. J Bacteriol, 2003 May. PMID 12730160, Free PMC Article
  5. The DegP and DegQ periplasmic endoproteases of Escherichia coli: specificity for cleavage sites and substrate conformation. Kolmar H, et al. J Bacteriol, 1996 Oct. PMID 8830688, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Up to six lysozyme substrates bind inside the DegQ 12-mer cage and are visualized in a close-to-native state.
    Title: Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ.
  2. analysis of how the the DegQ protease exerts protein quality control in the bacterial cell envelope
    Title: Molecular adaptation of the DegQ protease to exert protein quality control in the bacterial cell envelope.
  3. N-terminus verified by Edman degradation on mature peptide
    Title: '98 Escherichia coli SWISS-2DPAGE database update.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein quality control for misfolded or incompletely synthesized proteins IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis EXP
Inferred from Experiment
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis involved in protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in periplasmic space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in periplasmic space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in periplasmic space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
periplasmic serine endoprotease

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3380743..3382110
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417701.1 periplasmic serine endoprotease [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417701.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6N8QZL7
    Conserved Domains (1) summary
    PRK10139
    Location:1 → 455
    PRK10139; serine endoprotease DegQ
Nucleotide Protein
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Gene LinkOut

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