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cyaA adenylate cyclase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947755, updated on 19-Sep-2024

Summary

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Official Symbol
cyaA
Official Full Name
adenylate cyclase
Primary source
ECOCYC:EG10170
Locus tag
b3806
See related
ASAP:ABE-0012432
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
cya; ECK3800
Summary
Polyamine modulon. [More information is available at EcoGene: EG10170]. Adenylate cyclase catalyzes the synthesis of cyclic AMP (cAMP) by an intramolecular transfer of the adenylyl group of ATP to the 3'-hydroxy group, releasing pyrophosphate. cAMP is an important signaling molecule; the role of cAMP in regulating the production of metabolic enzymes was first summarized in . [More information is available at EcoCyc: EG10170].
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Genomic context

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Sequence:
NC_000913.3 (3991153..3993699)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene PF04375 family protein HemX Neighboring gene uroporphyrinogen-III synthase Neighboring gene hydroxymethylbilane synthase Neighboring gene frataxin CyaY Neighboring gene protein YzcX Neighboring gene putative lipoprotein YifL

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Purification and characterization of adenylate cyclase from Escherichia coli K12. Yang JK, et al. J Biol Chem, 1983 Mar 25. PMID 6300054
  2. The inhibition of E. coli adenyl cyclase by ara ATP. Ortiz PJ. Biochem Biophys Res Commun, 1972 Feb 25. PMID 4552540
  3. Isolation of adenyl cyclase from Escherichia coli. Tao M, et al. Proc Natl Acad Sci U S A, 1969 May. PMID 4897910, Free PMC Article
  4. Some properties of Escherichia coli adenyl cyclase. Tao M, et al. Arch Biochem Biophys, 1970 Nov. PMID 4921064
  5. Regulation of the synthesis of adenylate cyclase in Escherichia coli by the cAMP -- cAMP receptor protein complex. Majerfeld IH, et al. Mol Gen Genet, 1981. PMID 6267421

See all (89) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the CyaA(N600Y) mutant has a transcriptome indicative of increased CRP activity, pointing to an unknown role for CyaA and / or cAMP in gene expression..We show that the large scale transcriptomic changes in the topoisomerase I (FusA(A608E)-TopA(S180L)) mutant likely result from increased negative supercoiling in the cell.
    Title: Modulation of Global Transcriptional Regulatory Networks as a Strategy for Increasing Kanamycin Resistance of the Translational Elongation Factor-G Mutants in Escherichia coli.
  2. RNase LS regulates Crp-cAMP concentration by degrading the cyaA transcripts.
    Title: Post-transcriptional control of Crp-cAMP by RNase LS in Escherichia coli.
  3. The transcription of the cyaR gene is stringently controlled by cAMP-cAMP receptor protein and, unexpectedly, cyaR expression is also up-regulated, directly or indirectly, by sigma(E).
    Title: Down-regulation of outer membrane proteins by noncoding RNAs: unraveling the cAMP-CRP- and sigmaE-dependent CyaR-ompX regulatory case.
  4. A model for regulation of adenylate cyclase (AC) activity involves the interaction of the regulatory domain of AC with both a regulatory factor and enzyme component IIAGlc of the bacterial phosphoenolpyruvate phosphotransferase system.
    Title: In vitro reconstitution of catabolite repression in Escherichia coli.
  5. deletion of the catabolite repression regulators Crp and Cya resulted in a pronounced slow-growth phenotype but had only a nonspecific effect on the actual flux distribution.
    Title: Impact of global transcriptional regulation by ArcA, ArcB, Cra, Crp, Cya, Fnr, and Mlc on glucose catabolism in Escherichia coli.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenylate cyclase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables adenylate cyclase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cAMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cAMP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
adenylate cyclase
NP_418250.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3991153..3993699
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418250.1 adenylate cyclase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418250.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2H4TSR8, A0A377CC64
    Conserved Domains (1) summary
    COG3072
    Location:1 → 848
    CyaA; Adenylate cyclase [Nucleotide transport and metabolism]
Nucleotide Protein
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