U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

yhaV ribosome-dependent mRNA interferase toxin YhaV [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947638, updated on 19-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
yhaV
Official Full Name
ribosome-dependent mRNA interferase toxin YhaV
Primary source
ECOCYC:G7629
Locus tag
b3130
See related
ASAP:ABE-0010289
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3118
Summary
YhaV is the toxin component of the PrlF-YhaV antitoxin-toxin complex. [More information is available at EcoCyc: G7629].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (3277337..3277801)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene galactarate/D-glucarate transporter GarP Neighboring gene GarD Neighboring gene antitoxin PrlF Neighboring gene DNA-binding transcriptional repressor AgaR Neighboring gene putative tagatose-1,6-bisphosphate aldolase 1 chaperone

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Global Analysis of the Specificities and Targets of Endoribonucleases from Escherichia coli Toxin-Antitoxin Systems. Culviner PH, et al. mBio, 2021 Oct 26. PMID 34544284, Free PMC Article
  2. Functional Characterization of the C-Terminus of YhaV in the Escherichia coli PrlF-YhaV Toxin-Antitoxin System. Choi W, et al. J Microbiol Biotechnol, 2018 Jun 28. PMID 29642286
  3. Translation-dependent mRNA cleavage by YhaV in Escherichia coli. Choi W, et al. FEBS Lett, 2017 Jul. PMID 28573789
  4. mRNA interferases, sequence-specific endoribonucleases from the toxin-antitoxin systems. Yamaguchi Y, et al. Prog Mol Biol Transl Sci, 2009. PMID 19215780
  5. Increased expression of the bifunctional protein PrlF suppresses overproduction lethality associated with exported beta-galactosidase hybrid proteins in Escherichia coli. Kiino DR, et al. J Bacteriol, 1990 Jan. PMID 2152898, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest that the YhaV C-terminal region is essential for mRNA interferase activity, and the W143 or H154 residues may play an analogous role to Y87 of RelE.
    Title: Functional Characterization of the C-Terminus of YhaV in the Escherichia coli PrlF-YhaV Toxin-Antitoxin System.
  2. Data show that prlF and yhaV encode a novel toxin-antitoxin system in Escherichia coli.
    Title: prlF and yhaV encode a new toxin-antitoxin system in Escherichia coli.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables RNA endonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA nuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribosomal large subunit binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of growth NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in single-species biofilm formation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of toxin-antitoxin complex IEA
Inferred from Electronic Annotation
more info
  
part_of toxin-antitoxin complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
ribosome-dependent mRNA interferase toxin YhaV
NP_417599.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3277337..3277801
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417599.1 ribosome-dependent mRNA interferase toxin YhaV [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417599.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A775UC43
    Conserved Domains (1) summary
    pfam11663
    Location:12 → 143
    Toxin_YhaV; Toxin with endonuclease activity, of toxin-antitoxin system
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.