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cbpA curved DNA-binding protein [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947572, updated on 19-Sep-2024

Summary

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Official Symbol
cbpA
Official Full Name
curved DNA-binding protein
Primary source
ECOCYC:EG12193
Locus tag
b1000
See related
ASAP:ABE-0003379
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0991
Summary
DnaJ homolog. [More information is available at EcoGene: EG12193]. CbpA has similarity to DnaJ and functions as a co-chaperone with DnaK in vitro . [More information is available at EcoCyc: EG12193].
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Genomic context

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Sequence:
NC_000913.3 (1062855..1063775, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene trimethylamine N-oxide reductase 1 Neighboring gene trimethylamine-N-oxide reductase-specific chaperone Neighboring gene chaperone modulator CbpM Neighboring gene uncharacterized protein YccE Neighboring gene glucose-1-phosphatase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DNA recognition by Escherichia coli CbpA protein requires a conserved arginine-minor-groove interaction. Chintakayala K, et al. Nucleic Acids Res, 2015 Feb 27. PMID 25670677, Free PMC Article
  2. Dimerization and DNA-dependent aggregation of the Escherichia coli nucleoid protein and chaperone CbpA. Cosgriff S, et al. Mol Microbiol, 2010 Sep. PMID 20633229, Free PMC Article
  3. The rpoD gene functions as a multicopy suppressor for mutations in the chaperones, CbpA, DnaJ and DnaK, in Escherichia coli. Shiozawa T, et al. FEMS Microbiol Lett, 1996 May 1. PMID 9026454
  4. The cbpA chaperone gene function compensates for dnaJ in lambda plasmid replication during amino acid starvation of Escherichia coli. Wegrzyn A, et al. J Bacteriol, 1996 Oct. PMID 8824642, Free PMC Article
  5. A study of the double mutation of dnaJ and cbpA, whose gene products function as molecular chaperones in Escherichia coli. Ueguchi C, et al. J Bacteriol, 1995 Jul. PMID 7601860, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CbpA recognizes the minor groove of the double helix which is mediated by amino acid side chain R116, which sits at the boundary of the linker and C-terminal domain I.
    Title: DNA recognition by Escherichia coli CbpA protein requires a conserved arginine-minor-groove interaction.
  2. our work identifies a novel role for Fis and incorporates CbpA into the growing network of factors that mediate bacterial chromosome structure
    Title: E. coli Fis protein insulates the cbpA gene from uncontrolled transcription.
  3. Derivatives of CbpA that are unable to dimerize are also unable to bind DNA.
    Title: Dimerization and DNA-dependent aggregation of the Escherichia coli nucleoid protein and chaperone CbpA.
  4. These data demonstrate that CbpA activity is controlled at multiple levels.
    Title: Complex regulation of the DnaJ homolog CbpA by the global regulators sigmaS and Lrp, by the specific inhibitor CbpM, and by the proteolytic degradation of CbpM.
  5. N-terminus verified by Edman degradation on complete protein
    Title: An analogue of the DnaJ molecular chaperone in Escherichia coli.
  6. In a DnaJ mutant both CbpA and DjlA are required for efficient DnaK mediated protein dissaggregation at 42 degrees C.
    Title: The Escherichia coli DjlA and CbpA proteins can substitute for DnaJ in DnaK-mediated protein disaggregation.
  7. We discovered that CbpM specifically inhibits the in vivo activity of CbpA, preventing it from functioning in cell growth and division.
    Title: In vivo modulation of a DnaJ homolog, CbpA, by CbpM.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables bent DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables bent DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chaperone cofactor-dependent protein refolding IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within chaperone cofactor-dependent protein refolding IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within chaperone cofactor-dependent protein refolding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in bacterial nucleoid IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoid IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
curved DNA-binding protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1062855..1063775 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415520.1 curved DNA-binding protein [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415520.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376TJB6
    Conserved Domains (1) summary
    PRK10266
    Location:1 → 306
    PRK10266; curved DNA-binding protein
Nucleotide Protein
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