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motA motility protein A [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947564, updated on 19-Sep-2024

Summary

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Official Symbol
motA
Official Full Name
motility protein A
Primary source
ECOCYC:EG10601
Locus tag
b1890
See related
ASAP:ABE-0006299
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1891; flaJ
Summary
Flagellar regulon. [More information is available at EcoGene: EG10601]. MotA and MotB comprise the stator element of the flagellar motor complex. [More information is available at EcoCyc: EG10601].
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Genomic context

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Sequence:
NC_000913.3 (1976252..1977139, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene chemotaxis protein CheW Neighboring gene chemotaxis protein CheA Neighboring gene motility protein B Neighboring gene ncRNA Neighboring gene DNA-binding transcriptional dual regulator FlhC Neighboring gene DNA-binding transcriptional dual regulator FlhD

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The MotA protein of E. coli is a proton-conducting component of the flagellar motor. Blair DF, et al. Cell, 1990 Feb 9. PMID 2154333
  2. Overproduction of the MotA protein of Escherichia coli and estimation of its wild-type level. Wilson ML, et al. J Bacteriol, 1988 Feb. PMID 2828314, Free PMC Article
  3. Restoration of torque in defective flagellar motors. Blair DF, et al. Science, 1988 Dec 23. PMID 2849208
  4. Gene sequence and predicted amino acid sequence of the motA protein, a membrane-associated protein required for flagellar rotation in Escherichia coli. Dean GE, et al. J Bacteriol, 1984 Sep. PMID 6090403, Free PMC Article
  5. Gate-controlled proton diffusion and protonation-induced ratchet motion in the stator of the bacterial flagellar motor. Nishihara Y, et al. Proc Natl Acad Sci U S A, 2015 Jun 23. PMID 26056313, Free PMC Article

See all (79) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mechanosensitive recruitment of stator units promotes binding of the response regulator CheY-P to the flagellar motor.
    Title: Mechanosensitive recruitment of stator units promotes binding of the response regulator CheY-P to the flagellar motor.
  2. Charge-altering mutations affecting the conserved C-terminal cluster of negatively charged residues impair motility but do not diminish Mot protein levels.
    Title: Clusters of charged residues at the C terminus of MotA and N terminus of MotB are important for function of the Escherichia coli flagellar motor.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables proton channel activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in archaeal or bacterial-type flagellum-dependent cell motility IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within bacterial-type flagellum-dependent cell motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in bacterial-type flagellum-dependent cell motility NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in bacterial-type flagellum-dependent swarming motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in bacterial-type flagellum-dependent swarming motility IEA
Inferred from Electronic Annotation
more info
  
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in chemotaxis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within proton transmembrane transport TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in bacterial-type flagellum NAS
Non-traceable Author Statement
more info
 PubMed 
part_of bacterial-type flagellum stator complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
motility protein A

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1976252..1977139 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416404.1 motility protein A [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416404.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8T3UD58
    Conserved Domains (1) summary
    PRK09110
    Location:1 → 283
    PRK09110; flagellar motor stator protein MotA
Nucleotide Protein
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