alkA DNA-3-methyladenine glycosylase 2 [Escherichia coli str. K-12 substr. MG1655] -

Summary

Official Symbol: alkA
Official Full Name: DNA-3-methyladenine glycosylase 2
Primary source: ECOCYC:EG11222
Locus tag: b2068
See related: ASAP:ABE-0006848
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: aidA; ECK2062
Summary: The alk gene product is known as 3-methyladenine-DNA glycosylase II and is induced by exposure to alkylating agents as part of the cell's adaptive response to damage caused by alkylation. [More information is available at EcoCyc: EG11222].
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NC_000913.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Data suggest that AlkA actively interrogates the minor groove of the DNA while probing for the presence of lesions.
Title: Structure of Escherichia coli AlkA in complex with undamaged DNA.
N-terminus verified by Edman degradation on complete protein
Title: Structure and expression of the alkA gene of Escherichia coli involved in adaptive response to alkylating agents.
AlkB dioxygenase, PolV (UmuD'C), and AlkA have roles in preventing MMS-induced mutagenesis in Escherichia coli
Title: AlkB dioxygenase in preventing MMS-induced mutagenesis in Escherichia coli: effect of Pol V and AlkA proteins.

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Function	Evidence Code	Pubs
enables DNA-3-methyladenine glycosylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-3-methyladenine glycosylase activity	IEA Inferred from Electronic Annotation more info
enables DNA-3-methylguanine glycosylase activity	IEA Inferred from Electronic Annotation more info
enables DNA-7-methyladenine glycosylase activity	IEA Inferred from Electronic Annotation more info
enables DNA-7-methylguanine glycosylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-7-methylguanine glycosylase activity	IEA Inferred from Electronic Annotation more info
enables alkylated DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables alkylbase DNA N-glycosylase activity	IDA Inferred from Direct Assay more info	PubMed
enables alkylbase DNA N-glycosylase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA alkylation repair	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within DNA alkylation repair	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within DNA repair	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within base-excision repair	IDA Inferred from Direct Assay more info	PubMed
involved_in base-excision repair	IEA Inferred from Electronic Annotation more info
involved_in base-excision repair, AP site formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to stress	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of protein-DNA complex	IBA Inferred from Biological aspect of Ancestor more info

NP_416572.1

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The following sections contain reference sequences that belong to a specific genome build. Explain