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glrR DNA-binding transcriptional activator GlrR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947042, updated on 10-Oct-2024

Summary

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Official Symbol
glrR
Official Full Name
DNA-binding transcriptional activator GlrR
Primary source
ECOCYC:EG11285
Locus tag
b2554
See related
ASAP:ABE-0008400
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2551; qseF; yfhA
Summary
Characterized in an EPEC strain, QseC activates transcription of qseEGF in response to the autoinducer-3 (AI-3)/epinephrine/norepinephrine interkingdom signaling system (Reading, 2007). [More information is available at EcoGene: EG11285]. Purified YfhA can be phosphorylated in vitro by the cognate histidine kinase YfhK as well as by the non-cognate histidine kinases UhpB, RstB, and BaeS . [More information is available at EcoCyc: EG11285].
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Genomic context

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Sequence:
NC_000913.3 (2687469..2688803, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene nitric oxide dioxygenase Neighboring gene nitrogen regulatory protein PII-1 Neighboring gene outer membrane lipoprotein QseG Neighboring gene histidine kinase GlrK Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cascade control of Escherichia coli glutamine synthetase. Purification and properties of PII protein and nucleotide sequence of its structural gene. Son HS, et al. J Biol Chem, 1987 Jun 25. PMID 2885322
  2. The glnB region of the Escherichia coli chromosome. Liu J, et al. J Bacteriol, 1993 Nov. PMID 8226691, Free PMC Article
  3. Interaction of lipoprotein QseG with sensor kinase QseE in the periplasm controls the phosphorylation state of the two-component system QseE/QseF in Escherichia coli. Göpel Y, et al. PLoS Genet, 2018 Jul. PMID 30040820, Free PMC Article
  4. Isolation and nucleotide sequence of the hmp gene that encodes a haemoglobin-like protein in Escherichia coli K-12. Vasudevan SG, et al. Mol Gen Genet, 1991 Apr. PMID 2034230
  5. Dual control by perfectly overlapping sigma 54- and sigma 70- promoters adjusts small RNA GlmY expression to different environmental signals. Reichenbach B, et al. Mol Microbiol, 2009 Dec. PMID 19843219

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study reveal a three-component signaling system in E. coli K-12, in which membrane-bound QseE is stimulated through interaction with periplasmic QseG to phosphorylate cytoplasmic QseF.
    Title: Interaction of lipoprotein QseG with sensor kinase QseE in the periplasm controls the phosphorylation state of the two-component system QseE/QseF in Escherichia coli.
  2. QseE and QseF are involved in the transcriptional control of genes necessary for pedestal formation
    Title: The two-component system QseEF and the membrane protein QseG link adrenergic and stress sensing to bacterial pathogenesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphorelay response regulator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphorelay signal transduction system IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorelay signal transduction system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA-binding transcriptional activator GlrR

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2687469..2688803 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417049.1 DNA-binding transcriptional activator GlrR [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417049.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AT71, A0A7L7EIB0, A0AAN5UAA1
    Conserved Domains (1) summary
    PRK15115
    Location:1 → 444
    PRK15115; response regulator GlrR; Provisional
Nucleotide Protein
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