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bepA beta-barrel assembly-enhancing protease [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947029, updated on 10-Oct-2024

Summary

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Official Symbol
bepA
Official Full Name
beta-barrel assembly-enhancing protease
Primary source
ECOCYC:G7311
Locus tag
b2494
See related
ASAP:ABE-0008212
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2490; yfgC
Summary
Overexpression causes abnormal biofilm architecture. [More information is available at EcoGene: EG14199].
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Genomic context

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Sequence:
NC_000913.3 (2616094..2617557)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene formate channel FocB Neighboring gene putative transporter YfgO Neighboring gene putative oxidoreductase YfgD Neighboring gene inibitor of reinitiation of DNA replication

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural Basis for the Function of the β-Barrel Assembly-Enhancing Protease BepA. Shahrizal M, et al. J Mol Biol, 2019 Feb 1. PMID 30521812
  2. Protease homolog BepA (YfgC) promotes assembly and degradation of β-barrel membrane proteins in Escherichia coli. Narita S, et al. Proc Natl Acad Sci U S A, 2013 Sep 17. PMID 24003122, Free PMC Article
  3. Edge-strand of BepA interacts with immature LptD on the β-barrel assembly machine to direct it to on- and off-pathways. Miyazaki R, et al. Elife, 2021 Aug 31. PMID 34463613, Free PMC Article
  4. Genetic architecture of intrinsic antibiotic susceptibility. Girgis HS, et al. PLoS One, 2009 May 20. PMID 19462005, Free PMC Article
  5. Proteolytic activity of HtpX, a membrane-bound and stress-controlled protease from Escherichia coli. Sakoh M, et al. J Biol Chem, 2005 Sep 30. PMID 16076848

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein disulfide isomerase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Gram-negative-bacterium-type cell outer membrane assembly EXP
Inferred from Experiment
more info
 PubMed 
acts_upstream_of_or_within Gram-negative-bacterium-type cell outer membrane assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chaperone-mediated protein folding IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chaperone-mediated protein folding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within proteolysis involved in protein catabolic process EXP
Inferred from Experiment
more info
 PubMed 
involved_in proteolysis involved in protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis involved in protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in outer membrane-bounded periplasmic space TAS
Traceable Author Statement
more info
 PubMed 
located_in periplasmic space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
beta-barrel assembly-enhancing protease
NP_416989.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2616094..2617557
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416989.1 beta-barrel assembly-enhancing protease [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416989.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376WUW5, A0A8T3UHN6, A0AAN5VYR2
    Conserved Domains (2) summary
    COG4783
    Location:1 → 486
    YfgC; Putative Zn-dependent protease, contains TPR repeats [General function prediction only]
    sd00006
    Location:311 → 337
    TPR; TPR repeat [structural motif]
Nucleotide Protein
Heading Accession and Version

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