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cspE transcription antiterminator and regulator of RNA stability CspE [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947024, updated on 19-Sep-2024

Summary

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Official Symbol
cspE
Official Full Name
transcription antiterminator and regulator of RNA stability CspE
Primary source
ECOCYC:EG12179
Locus tag
b0623
See related
ASAP:ABE-0002142
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0616; gicA; msmC
Summary
The cspABEG deletion BX04 is cold-sensitive and forms filaments at 15C (Xia, 2001). [More information is available at EcoGene: EG12179]. CspE belongs to the cold shock family of proteins and was shown to be involved in a variety of cellular processes both in vitro and by studying mutants and overexpressing strains. [More information is available at EcoCyc: EG12179].
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Genomic context

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Sequence:
NC_000913.3 (657292..657501)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene anaerobic C4-dicarboxylate transporter DcuC Neighboring gene Lipid A palmitoyltransferase Neighboring gene F(-) channel protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nascent RNA in transcription complexes interacts with CspE, a small protein in E. coli implicated in chromatin condensation. Hanna MM, et al. J Mol Biol, 1998 Sep 18. PMID 9735283
  2. The mechanism of nucleic acid melting by a CspA family protein. Phadtare S, et al. J Mol Biol, 2004 Mar 12. PMID 15001358
  3. Three amino acids in Escherichia coli CspE surface-exposed aromatic patch are critical for nucleic acid melting activity leading to transcription antitermination and cold acclimation of cells. Phadtare S, et al. J Biol Chem, 2002 Nov 29. PMID 12324471
  4. A common regulator of cold and radiation response in Escherichia coli. Mangoli S, et al. J Environ Pathol Toxicol Oncol, 2001. PMID 11215702
  5. Posttranscriptional regulation of cspE in Escherichia coli: involvement of the short 5'-untranslated region. Uppal S, et al. FEMS Microbiol Lett, 2008 Feb. PMID 18177308

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CRP regulates cspE, an early cold-inducible gene.
    Title: Cyclic AMP receptor protein regulates cspE, an early cold-inducible gene, in Escherichia coli.
  2. N-terminus verified by Edman degradation on mature peptide
    Title: Nascent RNA in transcription complexes interacts with CspE, a small protein in E. coli implicated in chromatin condensation.
  3. Global transcript profiles of cells lacking cspE and cspC as well as cells individually overexpressing these proteins or a CspE mutant that is unable to melt nucleic acids and is defective in cold acclimation are reported.
    Title: Analysis of Escherichia coli global gene expression profiles in response to overexpression and deletion of CspC and CspE.
  4. A study of the mechanism of DNA melting by CspE.
    Title: Nucleic acid melting by Escherichia coli CspE.
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General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(A) binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription antitermination factor activity, RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of termination of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within transcription antitermination IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within transcription antitermination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transcription antiterminator and regulator of RNA stability CspE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    657292..657501
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415156.1 transcription antiterminator and regulator of RNA stability CspE [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415156.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S0FYV0
    Conserved Domains (1) summary
    PRK09507
    Location:1 → 69
    cspE; cold shock-like protein CspE
Nucleotide Protein
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