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xapA xanthosine phosphorylase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946878, updated on 19-Sep-2024

Summary

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Official Symbol
xapA
Official Full Name
xanthosine phosphorylase
Primary source
ECOCYC:G85
Locus tag
b2407
See related
ASAP:ABE-0007927
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2401; pndA
Summary
Guanosine and inosine are also substrates for XapA. [More information is available at EcoGene: EG20250]. The trimeric form is also active with less substrate specificity. [More information is available at EcoCyc: G85].
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Genomic context

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Sequence:
NC_000913.3 (2524045..2524878, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional activator XapR Neighboring gene xanthosine:H(+) symporter XapB Neighboring gene putative outer membrane porin YfeN Neighboring gene putative DNA-binding transcriptional regulator YfeR

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. New function for Escherichia coli xanthosine phophorylase (xapA): genetic and biochemical evidences on its participation in NAD(+) salvage from nicotinamide. Dong WR, et al. BMC Microbiol, 2014 Feb 8. PMID 24506841, Free PMC Article
  2. A second purine nucleoside phosphorylase in Escherichia coli K-12. II. Properties of xanthosine phosphorylase and its induction by xanthosine. Hammer-Jespersen K, et al. Mol Gen Genet, 1980. PMID 7007809
  3. Purification and properties of inosine-guanosine phosphorylase from Escherichia coli K-12. Koszalka GW, et al. J Bacteriol, 1988 Aug. PMID 3042752, Free PMC Article
  4. Effects of xapA and guaA disruption on inosine accumulation in Escherichia coli. Shimaoka M, et al. Biosci Biotechnol Biochem, 2006 Dec. PMID 17151449
  5. Escherichia coli purine nucleoside phosphorylase II, the product of the xapA gene. Dandanell G, et al. J Mol Biol, 2005 Apr 22. PMID 15808857

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables guanosine phosphorylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables inosine nucleosidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables purine-nucleoside phosphorylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables purine-nucleoside phosphorylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables purine-nucleoside phosphorylase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within NAD salvage EXP
Inferred from Experiment
more info
 PubMed 
involved_in deoxyguanosine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in deoxyinosine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in guanosine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in inosine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within nucleobase-containing small molecule interconversion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within nucleobase-containing small molecule metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleoside metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein hexamerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in purine nucleoside catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in purine nucleoside catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within xanthosine catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
xanthosine phosphorylase
NP_416902.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2524045..2524878 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416902.1 xanthosine phosphorylase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416902.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A775UUF4, A0A7A2QW49
    Conserved Domains (1) summary
    PRK08202
    Location:13 → 276
    PRK08202; purine nucleoside phosphorylase; Provisional
Nucleotide Protein
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