U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

mdtC multidrug efflux pump RND permease subunit MdtC [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946608, updated on 19-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
mdtC
Official Full Name
multidrug efflux pump RND permease subunit MdtC
Primary source
ECOCYC:G7115
Locus tag
b2076
See related
ASAP:ABE-0006877
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2072; yegO
Summary
mdtABC overexpression confers resistance to deoxycholate and novobiocin. [More information is available at EcoGene: EG14058]. In response regulator overproduction studies and deletion mutation experiments , the mdtABCD (yegMNOB) genes were found to constitute a multidrug resistance cluster which is regulated by the response regulator BaeR. [More information is available at EcoCyc: G7115].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (2158386..2161463)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene multidrug efflux pump membrane fusion protein MdtA Neighboring gene multidrug efflux pump RND permease subunit MdtB Neighboring gene putative multidrug efflux pump MdtD Neighboring gene sensor histidine kinase BaeS Neighboring gene DNA-binding transcriptional activator BaeR

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Multidrug efflux pump MdtBC of Escherichia coli is active only as a B2C heterotrimer. Kim HS, et al. J Bacteriol, 2010 Mar. PMID 20038594, Free PMC Article
  2. AcrB, AcrD, and MdtABC multidrug efflux systems are involved in enterobactin export in Escherichia coli. Horiyama T, et al. PLoS One, 2014. PMID 25259870, Free PMC Article
  3. The baeSR two-component regulatory system activates transcription of the yegMNOB (mdtABCD) transporter gene cluster in Escherichia coli and increases its resistance to novobiocin and deoxycholate. Baranova N, et al. J Bacteriol, 2002 Aug. PMID 12107134, Free PMC Article
  4. Global landscape of cell envelope protein complexes in Escherichia coli. Babu M, et al. Nat Biotechnol, 2018 Jan. PMID 29176613, Free PMC Article
  5. Beta-lactam resistance modulated by the overexpression of response regulators of two-component signal transduction systems in Escherichia coli. Hirakawa H, et al. J Antimicrob Chemother, 2003 Oct. PMID 12951338

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables bile acid transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables xenobiotic transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in bile acid and bile salt transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in xenobiotic detoxification by transmembrane export across the cell outer membrane NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in xenobiotic transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of efflux pump complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of efflux pump complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in periplasmic side of plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
multidrug efflux pump RND permease subunit MdtC

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2158386..2161463
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416580.1 multidrug efflux pump RND permease subunit MdtC [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416580.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7JW53
    Conserved Domains (1) summary
    PRK10614
    Location:1 → 1025
    PRK10614; multidrug efflux system subunit MdtC; Provisional
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.