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hisC histidinol-phosphate aminotransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946551, updated on 19-Sep-2024

Summary

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Official Symbol
hisC
Official Full Name
histidinol-phosphate aminotransferase
Primary source
ECOCYC:EG10446
Locus tag
b2021
See related
ASAP:ABE-0006717
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2016
Summary
Histidinol-phosphate aminotransferase (HisC) catalyzes the seventh step in the biosynthesis of histidine. [More information is available at EcoCyc: EG10446].
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Genomic context

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Sequence:
NC_000913.3 (2092398..2093468)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene his operon leader peptide Neighboring gene ATP phosphoribosyltransferase Neighboring gene histidinal/histidinol dehydrogenase Neighboring gene imidazoleglycerol-phosphate dehydratase/histidinol-phosphatase Neighboring gene imidazole glycerol phosphate synthase subunit HisH Neighboring gene 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase Neighboring gene imidazole glycerol phosphate synthase subunit HisF

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables histidinol-phosphate transaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histidinol-phosphate transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-histidine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within L-histidine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
histidinol-phosphate aminotransferase
NP_416525.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2092398..2093468
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416525.1 histidinol-phosphate aminotransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416525.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8I0CCU9
    Conserved Domains (1) summary
    PRK01688
    Location:3 → 352
    PRK01688; histidinol-phosphate aminotransferase; Provisional
Nucleotide Protein
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