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torA trimethylamine N-oxide reductase 1 [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946267, updated on 19-Sep-2024

Summary

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Official Symbol
torA
Official Full Name
trimethylamine N-oxide reductase 1
Primary source
ECOCYC:EG11814
Locus tag
b0997
See related
ASAP:ABE-0003372
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0988
Summary
Verified Tat substrate: [More information is available at EcoGene: EG11814]. TorA contains the active site and molybdenum cofactor . [More information is available at EcoCyc: EG11814].
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Genomic context

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Sequence:
NC_000913.3 (1059256..1061802)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene periplasmic trimethylamine-N-oxide binding protein Neighboring gene DNA-binding transcriptional dual regulator TorR Neighboring gene cytochrome c menaquinol dehydrogenase TorC Neighboring gene trimethylamine-N-oxide reductase-specific chaperone Neighboring gene chaperone modulator CbpM Neighboring gene curved DNA-binding protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of a pre-export enzyme-chaperone complex on the twin-arginine transport pathway. Dow JM, et al. Biochem J, 2013 May 15. PMID 23452237, Free PMC Article
  2. Molybdenum cofactor: a compound in the in vitro activation of both nitrate reductase and trimethylamine-N-oxide reductase activities in Escherichia coli K12. Silvestro A, et al. Biochim Biophys Acta, 1986 Aug 15. PMID 3524687
  3. [Assessment of the Escherichia coli Tat protein translocation system with fluorescent proteins]. Zhang M, et al. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai), 2003 Aug. PMID 12897964
  4. Regulation of the trimethylamine N-oxide (TMAO) reductase in Escherichia coli: analysis of tor::Mud1 operon fusion. Pascal MC, et al. Mol Gen Genet, 1984. PMID 6387391
  5. Enzymatic and physiological properties of the tungsten-substituted molybdenum TMAO reductase from Escherichia coli. Buc J, et al. Mol Microbiol, 1999 Apr. PMID 10216869

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Influence of the TorD signal peptide chaperone on Tat-dependent protein translocation.
    Title: Influence of the TorD signal peptide chaperone on Tat-dependent protein translocation.
  2. Immature TorA (apoTorA) is degraded in vivo and in vitro by the Lon protease. Lon interacts with apoTorA but not with holoTorA.
    Title: Quality control of a molybdoenzyme by the Lon protease.
  3. Data indicate that bis-MGD formed by MobA is fully functional and restores the catalytic activity in apoTorA.
    Title: Identification of a bis-molybdopterin intermediate in molybdenum cofactor biosynthesis in Escherichia coli.
  4. Translocation of TorA is directed by the TorD protein, which is a cytoplasmic chaperone known to interact physically with the TorA signal peptide.
    Title: Characterization of a pre-export enzyme-chaperone complex on the twin-arginine transport pathway.
  5. N-terminus verified by Edman degradation on mature peptide
    Title: A reassessment of the range of c-type cytochromes synthesized by Escherichia coli K-12.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables electron transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables electron transfer activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molybdenum ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molybdenum ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molybdopterin cofactor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables molybdopterin cofactor binding IEA
Inferred from Electronic Annotation
more info
  
enables molybdopterin cofactor binding ISM
Inferred from Sequence Model
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables trimethylamine-N-oxide reductase (cytochrome c) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables trimethylamine-N-oxide reductase (cytochrome c) activity IEA
Inferred from Electronic Annotation
more info
  
enables trimethylamine-N-oxide reductase (cytochrome c) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in aerobic respiration IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within aerobic respiration IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within anaerobic electron transport chain IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in anaerobic electron transport chain IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in anaerobic respiration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within anaerobic respiration IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of pH IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in outer membrane-bounded periplasmic space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in outer membrane-bounded periplasmic space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in periplasmic space IEA
Inferred from Electronic Annotation
more info
  
part_of trimethylamine-N-oxide reductase (cytochrome c) complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
trimethylamine N-oxide reductase 1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1059256..1061802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415517.1 trimethylamine N-oxide reductase 1 [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415517.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A895NXR9
    Conserved Domains (1) summary
    PRK15102
    Location:10 → 836
    PRK15102; trimethylamine-N-oxide reductase TorA
Nucleotide Protein
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