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ppsA phosphoenolpyruvate synthetase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946209, updated on 19-Sep-2024

Summary

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Official Symbol
ppsA
Official Full Name
phosphoenolpyruvate synthetase
Primary source
ECOCYC:EG10759
Locus tag
b1702
See related
ASAP:ABE-0005678
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1700; pps
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Genomic context

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Sequence:
NC_000913.3 (1784734..1787112, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative electron transfer flavoprotein-quinone oxidoreductase YdiS Neighboring gene ferredoxin-like protein YdiT Neighboring gene short chain acyl-CoA synthetase Neighboring gene phosphoenolpyruvate synthetase regulatory protein Neighboring gene 3-deoxy-7-phosphoheptulonate synthase, Trp-sensitive

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PpsA-mediated alternative pathway to complement RNase E essentiality in Escherichia coli. Tamura M, et al. Arch Microbiol, 2016 Jul. PMID 26883538
  2. Net formation of phosphoenolpyruvate from pyruvate by Escherichia coli. Cooper RA, et al. Biochim Biophys Acta, 1965 Jul 8. PMID 5322808
  3. On the mechanism of ATP cleavage in the phosphoenolpyruvate synthase reaction of Escherichia coli. Berman K, et al. Biochim Biophys Acta, 1967 Jun 13. PMID 4860971
  4. Kinetic competition in vitro between phosphoenolpyruvate synthetase and the pyruvate dehydrogenase complex from Escherichia coli. Chulavatnatol M, et al. J Biol Chem, 1973 Apr 25. PMID 4572512
  5. Phosphoenolpyruvate synthetase from Escherichia coli. Effects of adenylate energy charge and modifier concentrations. Chulavatnatol M, et al. J Biol Chem, 1973 Apr 25. PMID 4572511

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. demonstrate the role of phosphoryl transfer catalyzable by PpsA as a determinant of RNase E essentiality in E. coli.
    Title: PpsA-mediated alternative pathway to complement RNase E essentiality in Escherichia coli.
  2. In the present study, ppsA and tktA genes were overexpressed in genetically engineered Escherichia coli to enhance the availability of two precursor substrates, phosphoenolpyruvate and erythrose-4-phosphate.
    Title: Improved production of tryptophan in genetically engineered Escherichia coli with TktA and PpsA overexpression.
  3. N-terminus verified by Edman degradation on mature peptide
    Title: Cloning and nucleotide sequence of the Escherichia coli K-12 ppsA gene, encoding PEP synthase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables pyruvate, water dikinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyruvate, water dikinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in gluconeogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in pyruvate metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphoenolpyruvate synthetase
NP_416217.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1784734..1787112 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416217.1 phosphoenolpyruvate synthetase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416217.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2H4TZE7, A0A376M8G6
    Conserved Domains (1) summary
    PRK06464
    Location:6 → 792
    PRK06464; phosphoenolpyruvate synthase; Validated
Nucleotide Protein
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