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lsrG (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946073, updated on 19-Sep-2024

Summary

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Official Symbol
lsrG
Official Full Name
(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase
Primary source
ECOCYC:G6805
Locus tag
b1518
See related
ASAP:ABE-0005067
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1511; yneC
Summary
LsrG is part of an operon for autoinducer-2 (AI-2) uptake regulated by LsrR and LuxS, through AI-2. [More information is available at EcoGene: EG13811]. LsrG is an enzyme involved in the degradation of the quorum-sensing regulator Autoinducer 2 (AI-2). [More information is available at EcoCyc: G6805].
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Genomic context

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Sequence:
NC_000913.3 (1606999..1607289)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene Autoinducer-2 ABC transporter periplasmic binding protein Neighboring gene 3-hydroxy-2,4-pentadione 5-phosphate thiolase Neighboring gene trans-aconitate 2-methyltransferase Neighboring gene PF01062 family inner membrane protein YneE

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Processing the interspecies quorum-sensing signal autoinducer-2 (AI-2): characterization of phospho-(S)-4,5-dihydroxy-2,3-pentanedione isomerization by LsrG protein. Marques JC, et al. J Biol Chem, 2011 May 20. PMID 21454635, Free PMC Article
  2. Phosphorylation and processing of the quorum-sensing molecule autoinducer-2 in enteric bacteria. Xavier KB, et al. ACS Chem Biol, 2007 Feb 20. PMID 17274596
  3. Lsr-mediated transport and processing of AI-2 in Salmonella typhimurium. Taga ME, et al. Mol Microbiol, 2003 Nov. PMID 14622426
  4. The LuxS-dependent autoinducer AI-2 controls the expression of an ABC transporter that functions in AI-2 uptake in Salmonella typhimurium. Taga ME, et al. Mol Microbiol, 2001 Nov. PMID 11722742
  5. Regulation of uptake and processing of the quorum-sensing autoinducer AI-2 in Escherichia coli. Xavier KB, et al. J Bacteriol, 2005 Jan. PMID 15601708, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables intramolecular oxidoreductase activity, interconverting aldoses and ketoses IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in quorum sensing IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase
NP_416035.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1606999..1607289
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416035.1 (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416035.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376S8V7, W1F1C6
    Conserved Domains (1) summary
    PRK10486
    Location:1 → 96
    PRK10486; (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase
Nucleotide Protein
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