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paaH 3-hydroxyadipyl-CoA dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945940, updated on 19-Sep-2024

Summary

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Official Symbol
paaH
Official Full Name
3-hydroxyadipyl-CoA dehydrogenase
Primary source
ECOCYC:G6716
Locus tag
b1395
See related
ASAP:ABE-0004663
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1392; hbdH; ydbU
Summary
paaH mutants accumulate 3-hydroxyadipate. [More information is available at EcoGene: EG13742]. PaaH is a putative 3-hydroxy-acyl-CoA dehydrogenase involved in phenylacetate catabolism . [More information is available at EcoCyc: G6716].
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Genomic context

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Sequence:
NC_000913.3 (1459054..1460481)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene phenylacetyl-CoA 1,2-epoxidase, reductase subunit Neighboring gene putative 2,3-dehydroadipyl-CoA hydratase Neighboring gene putative ring 1,2-epoxyphenylacetyl-CoA isomerase (oxepin-CoA forming) Neighboring gene phenylacetyl-CoA thioesterase Neighboring gene beta-ketoadipyl-CoA thiolase Neighboring gene phenylacetate-CoA ligase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional genomics by NMR spectroscopy. Phenylacetate catabolism in Escherichia coli. Ismail W, et al. Eur J Biochem, 2003 Jul. PMID 12846838
  2. A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map. Aiba H, et al. DNA Res, 1996 Dec 31. PMID 9097039
  3. Bacterial phenylalanine and phenylacetate catabolic pathway revealed. Teufel R, et al. Proc Natl Acad Sci U S A, 2010 Aug 10. PMID 20660314, Free PMC Article
  4. Transcriptional regulation of the divergent paa catabolic operons for phenylacetic acid degradation in Escherichia coli. Ferrández A, et al. J Biol Chem, 2000 Apr 21. PMID 10766858
  5. Catabolism of phenylacetic acid in Escherichia coli. Characterization of a new aerobic hybrid pathway. Ferrández A, et al. J Biol Chem, 1998 Oct 2. PMID 9748275

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 3-hydroxyacyl-CoA dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3-hydroxybutyryl-CoA dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-hydroxybutyryl-CoA dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3-hydroxybutyryl-CoA dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD+ binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phenylacetate catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phenylacetate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phenylacetate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
3-hydroxyadipyl-CoA dehydrogenase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1459054..1460481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415913.1 3-hydroxyadipyl-CoA dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415913.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2X3JGB1
    Conserved Domains (1) summary
    TIGR02279
    Location:1 → 475
    PaaC-3OHAcCoADH; 3-hydroxyacyl-CoA dehydrogenase PaaC
Nucleotide Protein
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