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tyrR DNA-binding transcriptional dual regulator TyrR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945879, updated on 19-Sep-2024

Summary

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Official Symbol
tyrR
Official Full Name
DNA-binding transcriptional dual regulator TyrR
Primary source
ECOCYC:EG11042
Locus tag
b1323
See related
ASAP:ABE-0004440
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1319
Summary
The protein belongs to the EBP family. [More information is available at EcoCyc: EG11042].
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Genomic context

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Sequence:
NC_000913.3 (1386720..1388261)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional repressor YcjW Neighboring gene DUF463 domain-containing protein YcjX Neighboring gene DUF697 domain-containing inner membrane protein YcjF Neighboring gene lipid hydroperoxide peroxidase Neighboring gene L-Ala-D/L-Glu epimerase Neighboring gene murein tripeptide amidase A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pinpointing the L-phenylalanine binding sites of TyrR using biosensors and computer-aided simulation. Bai D, et al. Biotechnol Lett, 2019 Mar. PMID 30680497
  2. Altered oligomerization properties of N316 mutants of Escherichia coli TyrR. Koyanagi T, et al. J Bacteriol, 2008 Dec. PMID 18931124, Free PMC Article
  3. Crystal structure of the N-terminal domain of the TyrR transcription factor responsible for gene regulation of aromatic amino acid biosynthesis and transport in Escherichia coli K12. Verger D, et al. J Mol Biol, 2007 Mar 16. PMID 17222426
  4. The global gene expression response of Escherichia coli to L-phenylalanine. Polen T, et al. J Biotechnol, 2005 Feb 9. PMID 15639085
  5. The TyrR regulon. Pittard J, et al. Mol Microbiol, 2005 Jan. PMID 15612913

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Meta-Tyrosine Induces Cytotoxic Misregulation of Metabolism in Escherichia coli.
    Title: Meta-Tyrosine Induces Cytotoxic Misregulation of Metabolism in Escherichia coli.
  2. Residues at positions 160, 173 and 184 of TyrR protein are important for transcriptional activation of target genes tyrP induced by L-phenylalanine, which indicates that they are the bona fide L-phenylalanine binding sites of TyrR protein.
    Title: Pinpointing the L-phenylalanine binding sites of TyrR using biosensors and computer-aided simulation.
  3. N-terminus verified by Edman degradation on complete protein
    Title: The TyrR protein of Escherichia coli, analysis by limited proteolysis of domain structure and ligand-mediated conformational changes.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DNA-binding transcriptional dual regulator TyrR

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1386720..1388261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415839.1 DNA-binding transcriptional dual regulator TyrR [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415839.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376X2C0
    Conserved Domains (1) summary
    PRK10820
    Location:1 → 513
    PRK10820; transcriptional regulator TyrR
Nucleotide Protein
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