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hemA glutamyl-tRNA reductase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945777, updated on 19-Sep-2024

Summary

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Official Symbol
hemA
Official Full Name
glutamyl-tRNA reductase
Primary source
ECOCYC:EG10427
Locus tag
b1210
See related
ASAP:ABE-0004064
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1198; gtrA
Summary
Glutamyl-tRNA reductase catalyzes the first step of porphyrin biosynthesis. [More information is available at EcoCyc: EG10427].
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Genomic context

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Sequence:
NC_000913.3 (1263714..1264970)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase Neighboring gene outer membrane lipoprotein LolB Neighboring gene peptide chain release factor RF1 Neighboring gene protein-(glutamine-N(5)) methyltransferase Neighboring gene SirB family protein YchQ

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel hemA mutation is responsible for a small-colony-variant phenotype in Escherichia coli. Hubbard ATM, et al. Microbiology (Reading), 2021 Mar. PMID 32762803
  2. Regulation of heme biosynthesis in Salmonella typhimurium: activity of glutamyl-tRNA reductase (HemA) is greatly elevated during heme limitation by a mechanism which increases abundance of the protein. Wang LY, et al. J Bacteriol, 1997 May. PMID 9139907, Free PMC Article
  3. Control of the availability of exogenous 5-aminolevulinic acid in Escherichia coli. Nakayashiki T, et al. Genes Genet Syst, 1996 Aug. PMID 8979375
  4. Escherichia coli glutamyl-tRNA reductase. Trapping the thioester intermediate. Schauer S, et al. J Biol Chem, 2002 Dec 13. PMID 12370189
  5. Large scale production of biologically active Escherichia coli glutamyl-tRNA reductase from inclusion bodies. Schauer S, et al. Protein Expr Purif, 2003 Oct. PMID 14550647

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A novel hemA mutation is responsible for a small-colony-variant phenotype in Escherichia coli.
    Title: A novel hemA mutation is responsible for a small-colony-variant phenotype in Escherichia coli.
  2. analysis of glutamyl-tRNA reductase and glutamate-1-semialdehyde 2,1-aminomutase complex formation in Escherichia coli during the initial reactions of porphyrin biosynthesis
    Title: Complex formation between glutamyl-tRNA reductase and glutamate-1-semialdehyde 2,1-aminomutase in Escherichia coli during the initial reactions of porphyrin biosynthesis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables NADP binding IEA
Inferred from Electronic Annotation
more info
  
enables glutamyl-tRNA reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutamyl-tRNA reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutamyl-tRNA reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in porphyrin-containing compound biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protoporphyrinogen IX biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protoporphyrinogen IX biosynthetic process from glutamate IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protoporphyrinogen IX biosynthetic process from glutamate IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tetrapyrrole biosynthetic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glutamyl-tRNA reductase
NP_415728.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1263714..1264970
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415728.1 glutamyl-tRNA reductase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415728.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A3L5H0E4, A0A8S7NR24
    Conserved Domains (1) summary
    PRK00045
    Location:1 → 418
    hemA; glutamyl-tRNA reductase; Reviewed
Nucleotide Protein
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Gene LinkOut

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